The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(2), P. 276 - 294

Published: May 15, 2023

In this narrative review article, we discuss the role of sleep deprivation (SD) in memory processing rodent models. Numerous studies have examined effects SD on memory, with majority showing that disorders negatively affect memory. Currently, a consensus has not been established which damage mechanism is most appropriate. This critical issue neuroscience remains largely unknown. article aims to elucidate mechanisms underlie damaging It also proposes scientific solution might explain some findings. We chosen summarize literature both representative and comprehensive, as well innovative its approach. including synaptic plasticity, neuritis, oxidative stress, neurotransmitters. Results provide valuable insights into by impairs function.

Language: Английский

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Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: June 18, 2024

Abstract Fermenting Chinese medicinal herbs could enhance their bioactivities. We hypothesized probiotic-fermented gastrodia elata Blume (GE) with better potential to alleviate insomnia than that of unfermented, thus the changes in chemical composition and insomnia-alleviating effects mechanisms fermented GE on pentylenetetrazole (PTZ)-induced zebrafish were explored via high-performance liquid chromatography (HPLC) mass spectroscopy-coupled HPLC (HPLC-MS), phenotypic, transcriptomic, metabolomics analysis. The results demonstrated probiotic performed unfermented increasing content composition, reducing displacement, average speed, number apoptotic cells insomnia. Metabolomic investigation showed anti-insomnia effect was related regulating pathways actin cytoskeleton neuroactive ligand-receptor interactions. Transcriptomic reverse transcription qPCR (RT-qPCR) analysis revealed secondary fermentation (SFL) significantly modulated expression levels neurod1, msh2, msh3, recql4, ercc5, rad5lc, rev3l, which are mainly involved neuron differentiation DNA repair. Collectively, as a functional food, possessed for alleviation.

Language: Английский

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Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115575 - 115575

Published: April 1, 2025

Synchronisation of the suprachiasmatic nucleus (SCN) driven endogenous clock, located within central nervous system (CNS), and exogenous time cues, is essential for maintaining circadian rhythmicity, homeostasis overall wellbeing. Disordered rhythms have been associated with various conditions, inclusive neurodegenerative disorders, such as Alzheimer's disease Parkinson's disease. Traditional pharmacological approaches to dysfunction in disorders primarily focused on oral drug delivery. Oral medications often face challenges achieving necessary systemic circulation effectively bypass blood brain barrier (BBB) reach CNS, due low or variable bioavailability. Advancements non-invasive delivery methods, orally inhaled intranasal formulations, present promising alternatives targeting CNS. Orally allows rapidly achieve high through increased bioavailability fast onset action. Additionally, therapies BBB olfactory trigeminal nerve pathways directly enter This review assesses potential treat conditions. In addition, this will explore melatonin an example enhancing therapeutic outcomes by adopting formulations improve absorption target disorder more effectively.

Language: Английский

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Parkinson’s Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(6), P. 914 - 914

Published: June 6, 2023

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There a wide range sleep disturbances in patients with PD, such as insomnia and rapid eye movement (REM) behavior disorder (or REM (RBD)). RBD which patient acts out his/her dreams includes abnormal behaviors during phase sleep. On other hand, melatonin principal hormone that secreted by pineal gland significantly modulates circadian clock mood state. Furthermore, has regulatory effects safe treatment for PD. However, molecular mechanisms involved or control are unknown. In this study, we reviewed pathophysiology PD disturbances, including RBD. We also discussed potential its therapeutic effect. It was concluded disruption crucial neurotransmitter systems mediate sleep, norepinephrine, serotonin, dopamine, GABA, important phase, acetylcholine, induction accumulation α-synuclein sleep-related brain regions can disrupt processes rhythm. suggested new strategies may focus on modulation aggregation expression.

Language: Английский

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Nanostructured electrochemical platform for sensitive detection of melatonin in human serum and tablets

Synthetic Metals, Journal Year: 2024, Volume and Issue: 309, P. 117750 - 117750

Published: Sept. 16, 2024

Language: Английский

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Melatonin as a Chronobiotic/Cytoprotective Agent in REM Sleep Behavior Disorder

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(5), P. 797 - 797

Published: May 13, 2023

Dream-enactment behavior that emerges during episodes of rapid eye movement (REM) sleep without muscle atonia is a parasomnia known as REM disorder (RBD). RBD constitutes prodromal marker α-synucleinopathies and serves one the best biomarkers available to predict diseases such Parkinson disease, multiple system atrophy dementia with Lewy bodies. Most patients showing will convert an α-synucleinopathy about 10 years after diagnosis. The diagnostic advantage relies on prolonged time, its predictive power absence disease-related treatments could act confounders. Therefore, are candidates for neuroprotection trials delay or prevent conversion pathology abnormal α-synuclein metabolism. administration melatonin in doses exhibiting chronobiotic/hypnotic effect (less than mg daily) commonly used first line treatment (together clonazepam) RBD. At higher dose, may also be effective cytoprotector halt progression. However, allometric derived from animal studies (in 100 mg/day range) rarely employed clinically regardless demonstrated toxicity phase 1 pharmacological up normal volunteers. This review discusses application RBD: (a) symptomatic RBD; (b) possible disease-modifying α-synucleinopathies. To what degree has therapeutic efficacy prevention awaits further investigation, particular multicenter double-blind trials.

Language: Английский

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Potential of Machine Learning for Predicting Sleep Disorders: A Comprehensive Analysis of Regression and Classification Models

Diagnostics, Journal Year: 2023, Volume and Issue: 14(1), P. 27 - 27

Published: Dec. 22, 2023

Sleep disorder is a disease that can be categorized as both an emotional and physical problem. It imposes several difficulties problems, such distress during the day, sleep-wake disorders, anxiety, other problems. Hence, main objective of this research was to utilize strong capabilities machine learning in prediction sleep disorders. In specific, aimed meet three objectives. These objectives were identify best regression model, classification strategy highly suited datasets. Considering two related datasets evaluation metrics tasks classification, results revealed superiority MultilayerPerceptron, SMOreg, KStar models compared with twenty models. Furthermore, IBK, RandomForest, RandomizableFilteredClassifier showed superior performance belonged strategies. Finally, Function predictive among six considered strategies respect most metrics.

Language: Английский

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α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathway

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Jan. 27, 2024

Language: Английский

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Advances in Melatonin Research – A Review

Published: Jan. 1, 2024

The chemical known as melatonin, N-acetyl-5-methoxytryptamine, is widely dispersed and very versatile in its functional aspects. processes involving the retina biological clock that regulate pineal gland's circadian melatonin production are quickly being discovered, mechanisms governing synthesis within gland have been thoroughly studied. According to research, both endogenous exogenous, plays a significant role promoting physiological molecular adaptations domestic animals wildlife. Seasonally polyestrous subject of substantial research. Herds housed photoperiodic aberrations their circannual cycles corrected by supplementation procedures. One defining characteristics range techniques uses alter cell physiology biology. However, antioxidant immunostimulatory properties may be able mitigate these effects. During cycle, livestock undergo several metabolic adaptation impair immune system result chronic sickness, weight loss, or decreased productivity. Melatonin has an impact on heart blood vessels. It can vasodilate vasoconstrictor numerous systemic arteries, depending kind location receptors. This modulates animal's total nutrient partitioning through vascular resistance. physiological, cellular, impacts well-being illnesses domesticated food main topics this review, along with recent developments subject.

Language: Английский

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The Physiological Impact of Melatonin, Its Effect on the Course of Diseases and Their Therapy and the Effect of Magnetic Fields on Melatonin Secretion—Potential Common Pathways of Influence

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 929 - 929

Published: July 31, 2024

Melatonin is a relic, due to its millions-of-years-old presence in chemical reactions, found evolutionarily diverse organisms. It has multidirectional biological function. controls diurnal rhythms, redox homeostasis, intestinal motor functions, mitochondrial biogenesis and fetal development antioxidant effects. also analgesic therapeutic The purpose of this paper describe the role melatonin vital processes occurring interaction with environment, particular reference various magnetic fields ubiquitous life animate matter, especially radio frequency/extra low frequency (RF/ELF EMF) static fields. most important part article potential effects on secretion resulting possible health some cases positively amplifies electromagnetic signal, intensifying effects, such as neurogenesis, or lowering blood pressure. In other cases, it stimulus that inhibits destruction aggravation lesions. Sometimes, however, contrast beneficial therapy, they intensify pathogenic multiple sclerosis by inflammatory process.

Language: Английский

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