Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117034 - 117034
Published: Sept. 12, 2024
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102214 - 102214
Published: Feb. 2, 2024
Language: Английский
Citations
12
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117725 - 117725
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: May 31, 2024
Cu is an essential micronutrient for various physiological processes in almost all human cell types. Given the critical role of a wide range cellular processes, local concentrations and distribution transporter proteins lung are maintaining steady-state internal environment. Dysfunctional metabolism or regulatory pathways can lead to imbalance homeostasis lungs, affecting both acute chronic pathological processes. Recent studies have identified new form Cu-dependent death called cuproptosis, which has generated renewed interest diseases. Cuproptosis differs from other known pathways. This occurs through direct binding ions lipoylated components tricarboxylic acid cycle during mitochondrial respiration, leading aggregation subsequent downregulation Fe-S cluster proteins, causes toxic stress ultimately leads death. Here, we discuss impact dysregulated on pathogenesis respiratory diseases, including asthma, obstructive pulmonary disease, idiopathic interstitial fibrosis, cancer. We also therapeutic potential targeting Cu. study highlights intricate interplay between copper, health. Copper, while essential, must be carefully regulated maintain delicate balance necessity toxicity living organisms. review need further investigate precise mechanisms copper interactions with infections immune inflammation context diseases explore strategies related effects.
Language: Английский
Citations
5
Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(4), P. 1061 - 1080
Published: Feb. 10, 2024
Abstract We present a novel lung aerosol exposure system named MALIES (modular air–liquid interface system), which allows three-dimensional cultivation of epithelial cells in alveolar-like scaffolds (MatriGrids ® ) and to nanoparticle aerosols. consists multiple modular units for generation, can be rapidly assembled commissioned. The was proven its ability reliably produce dose-dependent toxicity A549 using CuSO 4 aerosol. Cytotoxic effects BaSO - TiO 2 -nanoparticles were investigated with the human tumor cell line cultured at . Experiments concentrations up 5.93 × 10 5 (BaSO 1.49 6 (TiO particles/cm 3 , resulting deposited masses 26.6 74.0 µg/cm performed two identical systems different laboratories. LDH, resazurin reduction total glutathione measured. grown on MatriGrids form ZO-1- E-Cadherin-positive barrier mucin surfactant protein. -NP mass resulted mild, reversible damage (~ 10% decrease viability) epithelium 24 h after exposure. did not induce any cytotoxicity 72 exposure, exception 1.7 fold increase low group laboratory 1. These results are consistent previous studies showing no significant by short-term treatment nanoscale vitro experiments.
Language: Английский
Citations
4
Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122972 - 122972
Published: Aug. 13, 2024
The complex process known as epithelial to mesenchymal transition (EMT) plays a fundamental role in several biological settings, encompassing embryonic development, wound healing, and pathological conditions such cancer fibrosis. In recent years, bulk of research has brought light the key copper, trace element with essential functions cellular metabolism, initiation progression. Indeed, besides functioning cofactor enzymes required for processes, energy production oxidation reactions, emerged an allosteric regulator kinases whose activity is fulfill dissemination through EMT. this comprehensive review, we try describe intricate relationship between metal copper EMT, spanning from earliest foundational studies latest advancements. Our aim shed on multifaceted roles undertaken by EMT unveil diverse mechanisms which homeostasis exerts its influence over regulators, signaling pathways, cell metabolic reprogramming transcription factors ultimately contributing spread cancer. Therefore, review not only may contribute deeper comprehension copper-mediated but also supports hypothesis that targeting counteract progression EMT-associated pathologies.
Language: Английский
Citations
4
Biotechnology Advances, Journal Year: 2025, Volume and Issue: 79, P. 108513 - 108513
Published: Jan. 5, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
0
Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(10), P. 4440 - 4449
Published: Dec. 29, 2023
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13975 - 13975
Published: Sept. 12, 2023
Copper (Cu) is an essential trace element for maintaining normal homeostasis in living organisms. Yet, elevated level of Cu beyond homeostatic capacity may lead to oxidative damage cellular components several organs, including the lungs. This work investigated effects curcumin (Curc) and nano-curcumin (nCurc) against Cu-induced lung injury, accenting roles stress, inflammation, nuclear factor erythroid 2-related factor/heme oxygenase-1 Nrf2/HO-1 pathway. Rats were challenged with 100 mg/kg copper sulfate (CuSO4) while being treated Curc or nCurc 7 days. Cu-triggered stress detected as dysregulation oxidative/antioxidant markers, a downregulation Nrf-2/HO-1 signaling, increase inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), intracellular adhesion molecule-1 (ICAM-1). Additionally, it decreased expression lung-specific proteins, surfactant protein-C (SP-C), mucin-1 (MUC-1), induced apoptosis, caused changes histology. alleviated CuSO4-induced injury by suppressing inflammation activating Nrf-2/HO-1. They also prevented apoptosis restored SP-C MUC-1. We concluded that exhibited superior efficacy compared mitigating injury. was associated reduced apoptotic responses increased signaling
Language: Английский
Citations
3
Records of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 1, P. 57 - 57
Published: Feb. 28, 2024
Fustin is a bioactive flavanonol, found in high concentrations Cotinus coggygria (European smoketree) heartwood and Toxicodendron vernicifluum (lacquer tree) [1].However, little known about its health benefits.The objective of this paper was to summarize the current evidence health-promoting effects fustin, registered animal human studies.In order sum up available data, research carried out global database Pubmed for published articles, related topic, period between 2015 January 2024 using keyword "fustin".A total 64 articles were after careful reviewing, 53 them ruled due lack relevance topic.Fustin documented exert ulcer-preventive [2], anticancer [3], antidiabetic antibacterial [3] neuroprotective [4] experimental studies.Clinical trials scarce anti-fibrotic effect only pharmacological activity one study [5].These ascribed antioxidant antiinflammatory activities flavonoid [6].Additional studies are required investigate health-beneficial fustin both clinical settings.
Language: Английский
Citations
0