Separations,
Journal Year:
2023,
Volume and Issue:
10(7), P. 412 - 412
Published: July 18, 2023
Maize
(Zea
mays
L.),
a
food
crop
cultivated
worldwide,
is
renowned
for
its
nutritional
and
economic
value.
However,
quality
can
be
significantly
affected
by
various
storage
conditions,
leading
to
changes
in
composition
potential
contamination
with
harmful
substances,
such
as
aflatoxins.
This
article
presents
comprehensive
evaluation
of
the
impact
on
maize
quality,
focusing
several
key
parameters
analyzed
using
liquid
chromatographic
methods
FT-NIR
spectrometry.
The
research
reveals
decline
concentrations
nutrients
over
period.
Specifically,
there
was
19.7%
loss
vitamin
B1,
12.43%
B3,
16.96%
α-tocopherol,
13.61%
total
tocopherols,
an
8.02%
β-carotene.
Aflatoxins
were
mostly
undetectable,
one
exception
January
that
remained
below
maximum
permitted
level
0.3
µg/kg.
include
concentration
vitamins
β-carotene,
aflatoxin
aflatoxins,
carbohydrate
content,
protein
content.
January—0.3
µg/kg—that
level.
study
underscores
importance
cooling
immediately
after
drying
minimize
nutrient
loss,
providing
valuable
insights
optimizing
processes
maintain
maize.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5305 - 5305
Published: May 13, 2024
The
current
review
aims
to
outline
and
summarize
the
latest
research
on
aflatoxin,
with
studies
describing
natural,
herbal
chemical
compound
applications
in
animal
(pig)
models
vitro
cellular
studies.
Aflatoxin,
a
carcinogenic
toxin
metabolite,
is
produced
by
Aspergillus
flavus
humid
environments,
posing
threat
human
health
crop
production.
treatment
involves
prevention
of
exposure
aflatoxin
counteracting
its
harmful
toxic
effects,
enabling
survival
an
antidote
for
aflatoxin.
To
prospects
influence
forage
farm
production,
food
processing.
application
remedies
treat
undergoing
development
pinpoint
biochemical
pathways
responsible
effects
transmission
actions
treatment.
underline
environmental
stress
meat
dairy
products;
describe
clinical
syndromes
associated
aflatoxicosis
that
are
counteracted
proposed
preventive
interventions.
understand
how
improve
animals
feed
conditions.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
284, P. 116854 - 116854
Published: Aug. 13, 2024
One
of
the
ways
Aflatoxin
B1
damages
liver
is
through
ferroptosis.
Ferroptosis
characterized
by
build-up
lipid
peroxides
and
reactive
oxygen
species
(ROS)
due
to
an
excess
iron.
Dietary
supplements
have
emerged
as
a
promising
strategy
for
treating
ferroptosis
in
liver.
The
flavonoid
component
hesperetin,
which
mostly
present
citrus
fruits,
has
number
pharmacological
actions,
such
those
against
fibrosis,
cancer,
hyperglycemia.
However,
hesperetin's
effects
mechanisms
hepatic
are
still
unknown.
In
this
study,
24
male
C57BL/6
J
mice
were
randomly
assigned
CON,
AFB1
(0.45
mg/kg/day),
AFB1+
hesperetin
treatment
groups
(40
mg/kg/day).
results
showed
that
improved
structural
damage
mouse
liver,
down-regulated
inflammatory
factors
(Cxcl1,
Cxcl2,
CD80,
F4/80),
alleviated
fibrosis
induced
aflatoxin
B1.
Hesperetin
reduced
peroxidation
iron
accumulation
up-regulating
levels
antioxidant
enzymes
(GPX4,
GSH-Px,
CAT,
T-AOC).
It
worth
noting
not
only
but
also
maintained
dynamic
balance
ions
reducing
ferritin
autophagy.
Mechanistically,
ability
regulate
autophagy
depends
on
PI3K/AKT/mTOR/ULK1
pathway.
AFB1-induced
HepG2
cells,
addition
PI3K
inhibitor
(LY294002)
AKT
(Miransertib)
confirmed
regulated
pathway
inhibit
degradation
lysosomes.
summary,
our
suggest
regulates
system
inhibits
hyperautophagy,
thereby
mitigate
peroxidation.
This
work
provides
fresh
perspective
mechanism
behind
mice.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(12)
Published: Nov. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: May 15, 2024
Abstract
Ferroptosis
is
a
novel
form
of
lipid
peroxidation-driven,
iron-dependent
programmed
cell
death.
Various
metabolic
pathways,
including
those
involved
in
and
iron
metabolism,
contribute
to
ferroptosis
regulation.
The
gut
microbiota
not
only
supplies
nutrients
energy
the
host,
but
also
plays
crucial
role
immune
modulation
balance.
In
this
review,
we
explore
pathways
associated
with
impact
on
host
metabolism.
We
subsequently
summarize
recent
studies
influence
regulation
by
discuss
potential
mechanisms
through
which
affects
ferroptosis.
Additionally,
conduct
bibliometric
analysis
relationship
between
context
chronic
kidney
disease.
This
can
provide
new
insights
into
current
research
status
future
microbiota.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(3), P. 352 - 352
Published: March 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
