Towards Improved Bioavailability of Cereal Inositol Phosphates, Myo-Inositol and Phenolic Acids DOI Creative Commons
Krzysztof Żyła, Aleksandra Duda‐Chodak

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 652 - 652

Published: Feb. 1, 2025

Cereals are among the foods rich in myo-inositol hexakisphosphate (phytic acid, IP6), lower phosphates (IPx), a wide range of phenolic compounds, as well vitamins, minerals, oligosaccharides, phytosterols and para-aminobenzoic attributed with multiple bioactivities, particularly associated prevention metabolic syndrome colon cancer. The bran fraction wheat, maize, brown rice other cereals contains high levels phytate, free total phenolics, endogenous enzymes such amylases, phytase, xylanase, β-glucanase feruloyl esterase, whose activities can be increased by germination. preliminary steps digestion begin oral cavity where substrates for action cereal salivary start to released from food matrix. IP6 phytate complexes arabinoxylans, starch protein bodies would eventually enhance absorption nutrients, including regulating tight junctions and, together ferulic acid (FA), maintain cell barrier integrity epithelial antibacterial immunity. In addition, both FA exert potent complementary antioxidant effects, while IPx generated through advanced hydrolysis microbial phytases may affect digestive enzyme activity incretin secretion, resulting modulated insulin glucagon release various diabetic complications. Contrary widespread negative attitudes towards this review, we present strategy selecting content, esterase endoxylanase activities, produce value-added health-promoting foods. compounds and/or generate substantial amounts “enzymatically inositol” (EGI), IP6, myo-inositol, that, FA, provide enhanced bioavailability nutrients synergistic effects not previously realised.

Language: Английский

Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut DOI Creative Commons

Xina Xiao,

Meng Hu,

Li Gao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 7, 2025

Abstract Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights importance of metabolic homeostasis protecting against oxidative large intestine. By developing low-input user-friendly pipeline for simultaneous profiling five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S -nitrosylation (SNO), -glutathionylation (SSG), we shed light on redox modification stoichiometries signaling with regional resolution gut monkeys. Notably, proteins modified by SOH SSG were associated primarily cell adhesion. In contrast, SNO-modified immunity. Interestingly, observed that Sto levels ranged from 0.97% to 99.88%, exhibiting two peaks increasing age. Crosstalk analysis revealed numerous age-related metabolites potentially modulating modifications. elucidated fumarate alleviating intestinal dextran sulfate sodium (DSS)-induced colitis mouse model. Our findings showed treatment promotes recovery several types, pathways, genes regulation. Calorie restriction (CR) is known strategy stress. Two-month CR intervention led many antioxidative reshaped redoxome. decodes complexities redoxomics during non-human primates identifies key signaling.

Language: Английский

Citations

1
A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame? DOI Creative Commons
Fatima Ahmad, Salma Ahmed, Fadi Choucair

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Female infertility is a multifactorial condition influenced by various genetic, environmental, and lifestyle factors. Recent research has investigated the significant impact of gut microbiome dysbiosis on systemic inflammation, metabolic dysfunction, hormonal imbalances, which can potentially impair fertility. The gut-brain axis, bidirectional communication system between brain, also plays role in regulating reproductive functions. Emerging evidence suggests that influence brain functions behavior, further emphasizing importance microbiota-gut-brain axis reproduction. Given their as major modulator microbiome, diet dietary factors, including patterns nutrient intake, have been implicated development management female infertility. Hence, this review aims to highlight patterns, such Western (WD) Mediterranean (MD), decipher modulatory action infertile women. By contrasting detrimental effects WD with therapeutic potential MD, we emphasize pivotal balanced rich nutrients promoting healthy microbiome. These insights underscore targeted interventions modifications promising strategies enhance outcomes subfertile

Language: Английский

Citations

1
Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD) DOI Open Access
Bharti Sharma,

George Agriantonis,

Kate Twelker

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2503 - 2503

Published: March 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn’s (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, microbial factors. Recent evidence highlights the gut microbiota as pivotal biomarker modulator in pathogenesis. Dysbiosis, characterized reduced diversity altered composition, hallmark of IBD. A consistent decrease anti-inflammatory bacteria, such Faecalibacterium prausnitzii, an increase pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) secondary bile acids, critical for homeostasis, alongside elevated metabolites. The interacts with host immune pathways, influencing morphogens, glycosylation, podoplanin (PDPN) expression. disruption glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, alterations contribute to oxidative stress, further destabilizing barriers. These molecular cellular disruptions underscore role microbiome pathophysiology. Emerging therapeutic strategies, probiotics, prebiotics, dietary interventions, aim restore balance mitigate Advanced on microbiota-targeted therapies their potential reduce severity improve patient outcomes. Nevertheless, research needed elucidate bidirectional interactions between responses translate these insights into clinical applications. This review consolidates current findings microbiota’s IBD, emphasizing its diagnostic implications, advocates continued exploration microbiome-based interventions combat this debilitating disease.

Language: Английский

Citations

1
The Role of Phytochemicals in Modulating the Gut Microbiota: Implications for Health and Disease DOI Creative Commons
Amandeep Singh, Prabhjot Kaur, Manish Kumar

et al.

Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100125 - 100125

Published: March 1, 2025

Language: Английский

Citations

1
Metal–Phenolic Networks for Chronic Wounds Therapy DOI Creative Commons
Danyang Wang, Jianfeng Xing, Ying Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6425 - 6448

Published: Nov. 1, 2023

Abstract: Chronic wounds are recalcitrant complications of a variety diseases, with pathologic features including bacterial infection, persistent inflammation, and proliferation reactive oxygen species (ROS) levels in the wound microenvironment. Currently, use antimicrobial drugs, debridement, hyperbaric therapy, other methods clinical for chronic treatment is prone to problems such as resistance, expansion, even exacerbation. In recent years, researchers have proposed many novel materials targeting disease characteristics, among which metal–phenolic networks (MPNs) supramolecular network structures that utilize multivalent metal ions natural polyphenols complexed through ligand bonds. They flexible versatile combination structural forms formations (nanoparticles, coatings, hydrogels, etc.) can be constructed. Functionally, MPNs combine chemocatalytic bactericidal properties well anti-inflammatory antioxidant polyphenol compounds. Together excellent rapid synthesis negligible cytotoxicity, attracted researchers' great attention biomedical fields anti-tumor, anti-bacterial, anti-inflammatory. This paper will focus on composition MPNs, mechanisms wounds, application therapies. Keywords: networks, antimicrobial, antioxidant, scavenging, revascularization

Language: Английский

Citations

17
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway DOI Creative Commons
Ling Wang, Yi‐Xuan Tu, Lu Chen

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 15, 2024

Abstract Consumption of dietary fiber and anthocyanin has been linked to a lower incidence colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes black rice diet (BRD), abundantly rich in anthocyanin. Our results demonstrate notable effects mice on BRD, indicated by reduction both size number intestinal tumors consequent extension life span, compared control diet‐fed counterparts. Furthermore, fecal transplants from BRD‐fed germ‐free led decrease colonic cell proliferation, coupled with maintained integrity barrier. The BRD was associated significant shifts gut microbiota composition, specifically an augmentation probiotic strains Bacteroides uniformis Lactobacillus . Noteworthy changes metabolites were also documented, including upregulation indole‐3‐lactic acid indole. These have identified stimulate aryl hydrocarbon receptor pathway, inhibiting CRC proliferation tumorigenesis. In summary, these findings propose that may modulate progression fostering protective metabolite profiles. accentuates health advantages whole‐grain foods, emphasizing utility promoting health.

Language: Английский

Citations

8
Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent DOI Open Access
Luisa Frusciante, Michela Geminiani, Tommaso Olmastroni

et al.

Published: March 26, 2024

The “circular bioeconomy” offers numerous opportunities for the health, cosmetic, and nutrition sectors through potential reuse of Castanea sativa by-products. This abundant sustainable resource provides valuable bioactive secondary metabolites with antioxidants anti-inflammatory properties. transformation these by-products into high-value products human health can contribute to economic growth reduce environmental impact traditional waste disposal practices, thus creating added value from previously underutilized resources. In present study, we investigated antioxidant capacity, phytochemical composition in vitro activity C. burrs (CSB) aqueous extract. spectrophotometric study yielded optimal total phenolic content (TPC) values, along significant anti-radical utilization UPLC-MS-MS techniques investigation resulted identification a 56 metabolites, providing confirmation presence compounds CSB. addition, CSB significantly downregulated pro-inflammatory mediators LPS-stimulated RAW 264.7 macrophage cells without cell toxicity.

Language: Английский

Citations

7
L‐Glutamine Substantially Improves 5‐Fluorouracil‐Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice DOI

Ya‐Ru Kuo,

Cheng‐Hung Lin, Weisheng Lin

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(9)

Published: April 24, 2024

This study investigates the potential of glutamine to mitigate intestinal mucositis and dysbiosis caused by chemotherapeutic agent 5-fluorouracil (5-FU).

Language: Английский

Citations

7
Exploring the Multifaceted Therapeutic Potential of Probiotics: A Review of Current Insights and Applications DOI

Kashyapi Chakravarty,

Smriti Gaur, Rohit Kumar

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: July 28, 2024

Language: Английский

Citations

7
Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease DOI Creative Commons

Wanyue Fu,

Zhongshi Huang, Weiqi Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

Citations

6