Biological potential and mechanisms of Tea’s bioactive compounds: An Updated review

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 65, P. 345 - 363

Published: Dec. 5, 2023

Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, categorized into green tea, white oolong yellow black dark tea based on the level of fermentation. Based review previous literature, commonly recognized bioactive substances in include polyphenols, amino acids, polysaccharides, alkaloids, terpenoids, macro minerals, trace elements, vitamins, which have been known to various potential health benefits, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, anti-obesity properties, cardiovascular protection, immune regulation, control intestinal microbiota. Most studies only pointed out characteristics tea's bioactivities, so comprehensive summary pharmacological mechanisms bioactivities their use risks are vital. Review The aim this paper summarize mechanisms, providing scientific basis for application outlining future research directions study tea. Key Scientific Concepts This summarizes main biologically active substances, effects, discusses risks. It may help researchers grasp more progress further promote natural substance medical field.

Language: Английский

---

Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

---

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1894 - 1894

Published: Oct. 23, 2023

Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic chronic diseases. Moreover, inflammation its different phases is necessary for the initiation maintenance healthy pregnancy. Therefore, an equilibrium between necessary/pathologic level during pregnancy needed avoid disease development. High-density lipoproteins (HDL) important good neonatal outcome. Their role fetal development challenging situations vital maintaining equilibrium. However, certain conditions, such as obesity, diabetes, other cardiovascular diseases, it has been observed HDL loses protective properties, becoming dysfunctional. Bioactive compounds have widely studied mediators but their mechanisms action still unknown. Nonetheless, these agents, which obtained from functional foods, increase concentration HDL, TRC, antioxidant activity. this review first summarizes several participation stress. Second, gives insight into how may act vector bioactive compounds. Third, describes relationships process Consequently, databases were used, including MEDLINE, PubMed, Scopus, where scientific articles published English language up 2023 identified.

Language: Английский

---

Anti-obesity potential of chickpea fermented by Lactiplantibacillus sp. (PMS-A6) from salted oyster: UPLC-ESI-Q-TOF-MSE profiling and in-vitro/in-vivo validation

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116133 - 116133

Published: March 6, 2025

Language: Английский

---

Metabolic Memory in Obesity: Can Early-Life Interventions Reverse Lifelong Risks?

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100610 - 100610

Published: April 1, 2025

Language: Английский

---

Use of postbiotics and parabiotics from lactobacilli in the treatment of infectious diarrhea

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 204, P. 107580 - 107580

Published: April 12, 2025

Language: Английский

---

Association between the Dietary Inflammatory Index and fracture risk in older adults: a systematic review and meta-analysis

Journal of International Medical Research, Journal Year: 2024, Volume and Issue: 52(5)

Published: May 1, 2024

Objective We explored correlations between the Dietary Inflammatory Index (DII) and fracture risk in older adults. Methods systematically searched MEDLINE, PubMed, Science Direct, Scopus, CNKI for all relevant epidemiological studies published through October 16, 2023. Because observational were included meta-analysis, we used a random-effects model to pool study-specific effect sizes 95% confidence intervals (CIs). assessed study quality using Newcastle–Ottawa scale. This meta-analysis was registered PROSPERO. Results Eight with 462,986 participants included, five cohort studies, two cross-sectional one case–control study. An analysis of heterogeneity among eight resulted I 2 = 87.1%, indicating significant between-study heterogeneity; hence, adopted generate combined size. found that DII positively associated (relative risk: 1.188, CI: 1.043–1.354). result further confirmed leave-one-out sensitivity analysis. Conclusions Our provides evidence suggesting diets high pro-inflammatory components might increase people. Decreased consumption foods increased anti-inflammatory are suggested prevent adverse outcomes. More prospective involving both sexes warranted verify results.

Language: Английский

---

Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in a High-Fat Diet-Induced Obese Mice

Published: Feb. 8, 2024

This study aimed to investigate the effect of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting 60% total calories for duration 12 weeks. PGA-K administration reduced increase in body weight, epididymal fat, and liver weight caused by compared obese group. The triglyceride, low-density lipoprotein cholesterol high-density levels, which are blood lipid indicators, were significantly increased group but decreased PGA-K-treated resulted significant inhibition pro-inflammatory cytokines, including tumor necrosis factor α interleukin 6. Moreover, levels leptin insulin, insulin resistance These results suggest that exhibits protective against obesity induced diet, underscoring its potential as candidate treatment.

Language: Английский

---

Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 809 - 809

Published: March 12, 2024

The purpose of this work was to examine the effects potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting 60% total calories for 12 weeks. PGA-K administration reduced increase in body weight, epididymal fat, and liver weight caused by compared obese group. triglyceride, low-density lipoprotein cholesterol high-density levels, which are blood lipid indicators, were significantly increased group but decreased PGA-K-treated resulted significant inhibition pro-inflammatory cytokines, including tumor necrosis factor α interleukin 6. Moreover, levels leptin insulin, insulin resistance These results suggest that exhibits protective effect against obesity induced diet, underscoring its potential as candidate treatment.

Language: Английский

---

Investigation on the lipid‐lowering effect and mechanism by combining turmeric with hawthorn in C57BL/6 obese mice

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(7), P. 4493 - 4504

Published: May 28, 2024

Study on the hypolipidemic effect of turmeric combined with hawthorn C57BL/6 obese mice and its possible mechanism. C57 were fed 60% high-fat diet for 8 weeks to establish an obesity model, 4 slaughtered verify whether modeling was successful. The successful divided into model group (HFD), positive (high fat feed [HFD] + simvastatin [SIM]), (HFD TUR), HAW), para-medicine para-drug [DOU]) by gavage intervention. Different intervention groups had certain lipid-lowering effects, showed significant differences (p < 0.05, p 0.01, 0.001) in reducing serum total cholesterol, triglycerides, low-density lipoprotein glutamic acid transaminase (ALT), (AST), increasing high-density cholesterol. In group, protein expression peroxisome proliferator-activated receptor γ, fatty synthase, platelet-reactive 36, CCAAT/enhancer binding α significantly downregulated, carnitine palmitoyl transferase1 0.001), thus suggesting that are superior alone enhancing lipid metabolism-related mechanisms. Combined effects improve metabolism mice, protect liver, liver-related genes. This study can lay theoretical basis future association medicinal food products development related weight loss products.

Language: Английский

---