Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 207 - 207

Published: Feb. 6, 2024

Cancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly 2030. There are various options of treatment for cancer, including surgery, radiotherapy, chemotherapy. All these have damaging adverse effects can reduce patient’s quality life. itself arises from a series mutations in normal cells generate ability divide uncontrollably. This cell mutation happen as result DNA damage induced high concentration ROS cells. High levels reactive oxygen species (ROS) cause oxidative stress, which initiate proliferation. On other hand, cytotoxic effect elevated be utilized anticancer therapy. Some bioactive compounds natural foods such fruit, vegetables, herbs, honey, many more identified promising source antioxidants prevent stress regulating level body. In this review, we highlighted discussed benefits antioxidant regulate through pathways.

Language: Английский

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Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 18, 2024

Abstract Background Insulin resistance (IR) significantly contributes to cardiovascular disease (CVD) development. Triglyceride glucose (TyG) index and triglyceride glucose-body mass (TyG-BMI) are recognised as convenient proxies for IR. However, their relationship with sudden cardiac arrest (SCA) remains unclear. Methods This prospective cohort analysis included 355,242 UK Biobank participants available TyG TyG-BMI data no history of CVD. Cox proportional risk models assessed the association between index, SCA risk. Additionally, Accelerated Failure Time (AFT) were employed investigate timing onset. The impact dynamic increases in levels on was examined using restricted cubic spline. Results Over a median follow-up period 165.4 months (interquartile range 156.5–174 months), 1,622 cases recorded. Multivariate regression revealed 9% increase per standard deviation (adjusted hazard ratio (aHR) = 1.09, 95% confidence interval (CI) 1.04–1.15) an 14% (aHR 1.14, CI 1.09–1.2). AFT indicated earlier times occurrence increasing quintiles compared lowest quintile (P trend < 0.05). linearly 0.54) non-linearly 0.007) correlated gradual levels, respectively. Sex-stratified analyses showed stronger associations women. Conclusions Higher associated increased onset, particularly

Language: Английский

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Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(4), P. 1153 - 1153

Published: Feb. 18, 2024

Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, α-D-mannans, are the main secondary metabolites of medicinal fungus Ganoderma lucidum. There is evidence effects acid in hematological malignancies, whose mechanisms involve stimulation immune response, macrophage-like differentiation, activation MAP-K pathway, an IL3-dependent cytotoxic action, induction cytoprotective autophagy, apoptosis. In fact, this compound has been tested twenty-six different human cancer cell types shown anti-proliferative activity, especially leukemia, lymphoma, myeloma lines. Moreover, research clarified capability molecules from lucidum to induce mitochondrial damage acute promyelocytic leukemia cells, without normal mononuclear cells. Active lipids extracted spores have also apoptosis mediated by downregulation P-Akt upregulation caspases-3, -8, -9. Among vivo studies, a study BALB/c mice injected with WEHI-3 leukemic cells suggested that treatment promotes differentiation T- B-cell precursors, phagocytosis PBMCs, NK activity. Our review presents data revealing possibility employing malignancies incorporating it into clinical practice.

Language: Английский

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Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11544 - 11544

Published: July 17, 2023

MicroRNAs are small, noncoding molecules of about twenty-two nucleotides with crucial roles in both healthy and pathological cells. Their expression depends not only on genetic factors, but also epigenetic mechanisms like genomic imprinting inactivation X chromosome females that influence a sex-dependent manner onset, progression, response to therapy different diseases cancer. There is evidence correlation between miRNAs, sex, cancer solid tumors hematological malignancies; as an example, lymphomas, prevalence rate higher men than women, miR-142 “silenced” because its hypermethylation by DNA methyltransferase-1 it blocked normal activity regulating the migration cell. This condition corresponds clinical practice more aggressive tumor. In addition, treatment can have advantages from evaluation miRNAs expression; fact, estrogens hepatocellular carcinoma determines upregulation oncosuppressors miR-26a, miR-92, miR-122 and, consequently, apoptosis. The aim this review present exhaustive collection scientific data possible role sex differences through which cancerogenesis, autophagy, apoptosis cells diverse types tumors.

Language: Английский

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The Interplay between Medical Plants and Gut Microbiota in Cancer

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3327 - 3327

Published: July 26, 2023

The gut microbiota is a dynamic community of bacteria distributed in the gastroenteric tract and changes response to diseases, diet, use antibiotics probiotics, hygiene status, other environmental factors. Dysbiosis, disruption normal crosstalk between host microbes, associated with obesity, diabetes, cancer, cardiovascular linked reduction anti-inflammatory like Lactobacillus Roseburia, an increase growth proinflammatory species Ruminococcus gnavus Bacteroidetes. Some plants possess anticancer properties various studies have reported that some these are also able modulate microbiota. aim this work evaluate crucial relationship medical consequences on onset progression cancer. In vivo about hematological malignancies showed beta-glucans tie endogenous antibeta glucan antibodies iC3b, opsonic fragment central complement protein C3, leading phagocytosis antibody-targeted neoplastic cells potentiation cytotoxic activity innate immune system if administered together monoclonal antibodies. conclusion, review suggests potential improve dysbiosis assist treatment

Language: Английский

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Testosterone, β-estradiol, and hepatocellular carcinoma: stimulation or inhibition? A comparative effect analysis on cell cycle, apoptosis, and Wnt signaling of HepG2 cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(8), P. 6121 - 6133

Published: Feb. 29, 2024

Language: Английский

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Shifting cold to hot tumors by nanoparticle-loaded drugs and products

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Language: Английский

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Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Diet quality is closely related to the occurrence of gastrointestinal (GI) cancers; however, few studies have investigated association between Healthy Eating Index (HEI-2020) and alternative Mediterranean diet (aMED) scores GI cancers. This study aims assess HEI-2020, aMED Information from a total 26,320 participants was included in National Health Nutrition Examination Survey (NHANES). In our sub-analysis, we focused on with complete dietary health data, specifically assessing relationship cancers outcomes. The 24-hour recall questionnaire used collect participants' average intake. Diagnoses were based self-reported medical history confirmed through physician interviews or linked cancer registry ensuring diagnostic reliability. Logistic regression models, restricted cubic splines (RCS), subgroup analysis, interaction methods employed fully evaluate associations scores, Mediation analysis also conducted identify potential mediators this relationship. Even after adjusting for confounders, high adherence HEI-2020-2020 significantly associated reduced risk Compared lowest tertile highest had 30% (OR 0.70, 95% CI 0.50 0.98, p = 0.037). 37% 0.63, 0.44 0.92, 0.014). RCS indicated that both HEI-2020 no significant non-linear observed. primary findings confirm higher lower These results suggest maintaining high-quality may play crucial role prevention management these Further research needed elucidate mechanisms effects healthy diets

Language: Английский

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Spermatozoa as harbingers of mortality: the curious link between semen quality and life expectancy

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

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Mitigating AFB1 and OTA hepatic residues using pumpkin and milk fermented whey as functional ingredients

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106565 - 106565

Published: April 1, 2025

Language: Английский

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