Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(2), P. 404 - 404
Published: Feb. 13, 2025
The
early
weaning
of
lambs
frequently
leads
to
weakened
immunity,
impaired
intestinal
function,
and
increased
susceptibility
disease.
Lactobacillus
plays
a
role
in
regulating
enhancing
antioxidant
capacity,
maintaining
health.
This
study
aims
isolate
strain
with
favorable
probiotic
properties
from
sheep
feces
investigate
its
effects
on
the
health
early-weaned
lambs.
In
this
study,
growth
characteristics,
acid
production
bacteriostatic
bile
salt
tolerance,
gastrointestinal
fluid
self-coagulation
surface
hydrophobicity
isolated
were
analyzed
for
vitro
properties.
Lactobacilli
strong
used
vivo
validation.
A
total
72
Hu
allocated
into
four
groups:
ewe-reared
group
(ER),
early-weaning
(EW),
low-dose
(LL),
high-dose
(HL).
Early
was
performed
EW,
LL,
HL
groups
at
age
28
days.
johnsonii
M5
(L.
M5),
feces,
exhibited
vitro.
Feeding
EW
low
dose
L.
significantly
reduced
their
diarrhea
rate
(p
<
0.05).
Its
supplementation
levels
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GSH-Px)
capacity
(T-AOC)
serum
jejunal
mucosa
decreased
malondialdehyde
(MDA)
Compared
group,
immunoglobulin
G
(IgG)
LL
feeding
content
anti-inflammatory
cytokines,
while
reducing
pro-inflammatory
cytokines
also
crypt
depth
occludin
claudin-1
These
findings
indicate
that
enhances
immunity
improving
health,
mitigates
Animals,
Journal Year:
2025,
Volume and Issue:
15(4), P. 559 - 559
Published: Feb. 14, 2025
This
study
investigated
the
effect
of
Brown
algae
polysaccharides
(BAPs)
on
diquat-induced
oxidative
stress
in
piglets
and
IPEC-J2
cells
through
Nrf2/ARE
signaling
pathway.
In
vivo
model,
24
male
Duroc
×
Landrace
Large
White
breed
were
selected
divided
into
4
groups
(n
=
6),
including
CON
group
(basal
diet),
DIQ
(10
mg/kg
Diquat),
BAP
(1000
BAP),
BAP+DIQ
+
10
Diquat).
Compared
with
group,
improved
growth
performance
reduced
levels
IL-1β,
IL-6,
TNF-α,
DAO
plasma,
increased
VH
VCR,
jejunal
tissue
morphology,
decreased
MDA
levels,
T-AOC
(p
<
0.05).
Additionally,
elevated
mRNA
ZO-1,
enhanced
protein
Occludin,
Claudin1,
CAT,
SOD1,
HO-1
vitro
T-AOC,
CAT
SOD2,
as
well
HO-1,
total
Nrf2
compared
Furthermore,
nuclear
promoted
translocation
from
cytoplasm
to
nucleus
conclusion,
BAPs
are
crucial
for
enhancing
piglets'
antioxidant
capacity
via
pathway
activation.
These
findings
highlight
BAP's
potential
a
natural
feed
additive
mitigate
improve
overall
health
piglets.
Further
research
is
warranted
explore
dietary
supplement
support
gut
reduce
stress.
npj Biofilms and Microbiomes,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 8, 2025
Oral
potentially
malignant
disorders
(OPMDs)
and
gastrointestinal
precancerous
lesions
(GPLs)
are
major
public
health
concerns
because
of
their
potential
to
progress
cancer.
Probiotics,
prebiotics,
engineered
probiotics
can
positively
influence
the
prevention
management
OPMDs
GPLs.
This
review
aims
comprehensively
application
status
probiotics,
prebiotics
in
GPLs,
explore
mechanisms
action,
anticipate
future
clinical
use.
Biology,
Journal Year:
2023,
Volume and Issue:
13(1), P. 8 - 8
Published: Dec. 22, 2023
This
review
summarizes
the
protective
effects
of
probiotics
against
Alzheimer’s
disease
(AD),
one
most
common
neurodegenerative
disorders
affecting
older
adults.
is
characterized
by
deposition
tau
and
amyloid
β
peptide
(Aβ)
in
different
parts
brain.
Symptoms
observed
patients
with
AD
include
struggles
writing,
speech,
memory,
knowledge.
The
gut
microbiota
reportedly
plays
an
important
role
brain
functioning
due
to
its
bidirectional
communication
via
gut–brain
axis.
emotional
cognitive
centers
are
linked
functions
peripheral
intestinal
system
this
Dysbiosis
has
been
disorders,
indicating
significance
homeostasis
for
proper
function.
Probiotics
play
protecting
symptoms
as
they
restore
a
great
extent.
characteristics,
status
axis,
AD.
Review
research
articles
related
treatment
were
searched
PubMed
database.
Recent
studies
conducted
using
animal
models
given
preference.
clinical
trials
separately.
Several
on
human
clearly
explain
benefits
improving
cognition
memory
experimental
subjects.
Based
these
studies,
novel
therapeutic
approaches
can
be
designed
Animal nutrition,
Journal Year:
2024,
Volume and Issue:
19, P. 13 - 24
Published: July 14, 2024
Newborn
goat
kids
exposed
to
environmental
stress
are
susceptible
diarrhea
due
immature
intestinal
functions
and
undeveloped
gut
microbiota.
Butyrate-producing
bacteria
as
next
generation
probiotics
benefit
the
maintenance
of
health,
but
mode
regulation
is
still
unclear.
Herein,
a
novel
butyrate-producing
strain
was
isolated
from
sheep
rumen
identified
Clostridium
beijerinckii
R8
(C.
beijerinckii),
thereafter
were
treated
with
C.
elucidate
its
regulatory
mechanisms
on
diarrhea.
Thirty-six
assigned
four
groups:
control
(CON),
low
dose
(LCB),
middle
(MCB),
high
(HCB)
addition
beijerinckii.
The
experiment
lasted
for
15
d,
6
randomly
selected
each
group
slaughter
last
day
trial.
results
showed
that
this
isolate
reduced
rate
(P
<
0.001)
fecal
scores
0.001).
In
gut,
supplementation
inhibited
inflammation,
increased
antioxidant
capacity,
regulated
flora.
Meanwhile,
strengthened
barrier
altered
jejunum
morphology.
This
evidence
suggests
may
alleviate
in
by
regulating
microbiota,
which
directly
related
immune
capacity.
