Foods,
Journal Year:
2024,
Volume and Issue:
13(24), P. 4155 - 4155
Published: Dec. 22, 2024
Hops
(Humulus
lupulus
L.)
are
widely
recognized
for
their
use
in
brewing,
but
they
also
possess
significant
pharmacological
properties
due
to
rich
bioactive
compounds,
with
many
varieties
exhibiting
diverse
characteristics.
This
study
investigates
the
chemical
composition
and
biological
activities
of
extracts
from
six
hop
varieties,
focusing
on
quantifying
xanthohumol
lupulone
using
High-Performance
Liquid
Chromatography
(HPLC)
Total
Phenolic
Content
(TPC)
analysis.
The
demonstrated
variability
compound
concentrations,
Aurora
showing
highest
(0.665
mg/g)
Zwiegniowski
(9.228
mg/g).
TPC
analysis
revealed
had
phenolic
content
(22.47
mg
GAE/g).
Antioxidant
were
evaluated
DPPH,
ABTS,
CUPRAC,
FRAP
assays,
Oregon
Fuggle
displaying
most
potent
capacities.
Aurora,
particular,
showed
activity
across
multiple
including
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
inhibition,
IC50
values
24.39
mg/mL,
20.38
9.37
respectively.
chelating
was
assessed,
Apolon
demonstrating
strongest
metal
ion
binding
capacity
(IC50
=
1.04
mg/mL).
Additionally,
exhibited
effective
hyaluronidase
inhibition
10.27
mg/mL),
highlighting
its
potential
anti-inflammatory
applications.
results
underscore
influence
genetic
environmental
factors
profiles
offering
promising
avenues
pharmaceutical
nutraceutical
However,
further
studies
needed
fully
understand
interactions
between
cones
components.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(10), P. 1827 - 1827
Published: Oct. 4, 2023
Cannabis
sativa,
a
versatile
plant
with
numerous
varieties,
holds
promising
potential
for
wide
range
of
biological
activity.
As
raw
materials
research,
we
chose
leaves
and
inflorescences
hemp
varieties
such
as
Białobrzeskie,
Henola,
Tygra,
which
are
cultivated
mainly
their
fibers
or
seeds.
The
choice
extraction
is
key
step
in
obtaining
the
selected
compositions
active
compounds
from
material.
Bearing
mind
lipophilic
nature
cannabinoids,
performed
supercritical
carbon
dioxide
(scCO2)
at
50
°C
under
2000
(a)
6000
PSI
(b).
cannabinoid
contents
were
determined
use
HPLC-DAD
method.
antioxidant
capabilities
assessed
through
series
procedures,
including
DPPH,
ABTS,
CUPRAC,
FRAP
methods.
capacity
to
inhibit
enzymes
that
play
role
progression
neurodegenerative
diseases,
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
was
also
studied.
dominant
cannabinoids
extracts
cannabidiol
(CBD)
cannabidiolic
acid
(CBDA).
highest
concentration
eight
detected
Tygra
extract
most
notable
properties
provided
by
Nonetheless,
it
Henola
(b)
demonstrated
efficient
inhibition
AChE
BChE,
inhibited
significantly
Białobrzeskie
Multidimensional
comparative
analysis
enrolled
all
assays
revealed
showed
substantial
neuroprotective
potential.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2280 - 2280
Published: Sept. 4, 2023
Cannabinoids:
cannabidiol
(CBD),
cannabidiolic
acid
(CBDA),
and
cannabichromene
(CBC)
are
lipophilic
compounds
with
limited
water
solubility,
resulting
in
challenges
related
to
their
bioavailability
therapeutic
efficacy
upon
oral
administration.
To
overcome
these
limitations,
we
developed
co-dispersion
cannabinoid
delivery
systems
the
biopolymer
polyvinyl
caprolactam-polyvinyl
acetate-polyethylene
glycol
(Soluplus)
magnesium
aluminometasilicate
(Neusilin
US2)
improve
solubility
permeability.
Recognizing
potential
benefits
arising
from
entourage
effect,
decided
work
an
extract
instead
of
isolated
cannabinoids.
Cannabis
sativa
inflorescences
(Henola
variety)
a
confirming
neuroprotective
activity
were
subjected
dynamic
supercritical
CO2
(scCO2)
extraction
next
they
combined
carriers
(1:1
mass
ratio)
prepare
(HiE).
In
vitro
dissolution
studies
conducted
evaluate
CBD,
CBDA,
CBC
various
media
(pH
1.2,
6.8,
fasted,
fed
state
simulated
intestinal
fluid).
The
HiE-Soluplus
consistently
demonstrated
highest
rate
Additionally,
exhibited
permeability
coefficients
for
cannabinoids
gastrointestinal
tract
conditions
than
it
was
during
using
model
PAMPA
GIT.
All
three
promising
blood-brain
barrier
(BBB)
(Papp
higher
4.0
×
10−6
cm/s),
suggesting
effectively
cross
into
central
nervous
system.
improved
system
hold
promise
enhancement
bioavailability.
Gels,
Journal Year:
2024,
Volume and Issue:
10(12), P. 770 - 770
Published: Nov. 26, 2024
The
therapeutic
potential
of
Cannabis
sativa
L.
extract
has
gained
significant
attention
due
to
its
diverse
medical
applications.
Sublingual
administration
remains
a
common
delivery
method
cannabinoids;
however,
challenges
often
arise
the
inconvenient
form
and
taste.
To
address
these
issues,
novel
bigel
formulation
was
developed,
combining
water
oil
phases
enhance
stability
bioavailability.
This
incorporates
cannabidiol-rich
hemp
extract,
hyaluronic
acid
for
moisturizing
properties,
taste-masking
agent
improve
patient
compliance
comfort.
Using
standardized
rich
in
cannabinoids
well-characterized
terpene
profile,
printability
bigels
evaluated
through
3D
printing
technology.
A
printout
with
known
cannabidiol
(CBD)
cannabidiolic
(CBDA)
content
11.613
mg
±
0.192
CBD
4.732
0.280
CBDA
obtained.
In
addition,
release
profile
determine
efficiency
active
ingredient—dissolved
ingredient
levels
ranged
from
74.84%
0.50
80.87%
3.20
80.84
1.33
98.31
1.70
depending
on
formulation.
Rheological
studies
were
conducted
evaluate
viscosity
under
varying
temperature
conditions,
ensuring
their
usability.
Findings
suggest
that
this
3D-printed
could
significantly
cannabis
extracts,
offering
more
convenient
effective
option
patients.
research
underscores
importance
innovation
cannabinoid
therapies
paves
way
further
advancements
personalized
medicine.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(12), P. 2052 - 2052
Published: Nov. 28, 2023
The
development
and
progression
of
cancer
are
associated
with
the
dysregulation
multiple
pathways
involved
in
cell
proliferation
survival,
as
well
dysfunction
redox
balance,
immune
response,
inflammation.
master
antioxidant
pathway,
known
nuclear
factor
erythroid
2-related
2
(Nrf2)
regulates
cellular
defense
against
oxidative
stress
inflammation,
making
it
a
promising
prevention
treatment
target.
Cannabinoids
have
demonstrated
anti-tumor
anti-inflammatory
properties,
affecting
signaling
pathways,
including
Nrf2.
Increased
following
exposure
to
anti-cancer
therapy
prompts
cells
activate
mechanisms.
This
indicates
dual
effect
Nrf2
cells-influencing
apoptotic
processes
protecting
toxicity
therapy.
Therefore,
understanding
complex
role
cannabinoids
modulating
might
shed
light
on
its
potential
implementation
an
support.
In
this
review,
we
aim
highlight
impact
Nrf2-related
factors,
focus
treatment.
Additionally,
presented
results
several
research
studies
that
combined
cannabidiol
(CBD)
other
compounds
targeting
Further
should
be
directed
toward
exploring
effects
context
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1714 - 1714
Published: Sept. 4, 2023
Cannabidiol
(CBD)
is
a
nonpsychoactive
phytocannabinoid
that
can
be
found
in
Cannabis
sativa
and
possesses
numerous
pharmacological
effects.
Due
to
these
promising
effects,
CBD
used
wide
variety
of
diseases,
for
instance
cardiovascular
diseases.
However,
CBD,
like
tetrahydrocannabinol
(THC),
has
low
bioavailability,
poor
water
solubility,
variable
pharmacokinetic
profile,
which
hinders
its
therapeutic
use.
Chemical
derivatization
offers
us
potential
ways
overcome
issues.
We
prepared
three
new
derivatives
substituted
on
the
aromatic
ring
by
Mannich-type
reactions,
have
not
been
described
so
far
modification
cannabinoids,
studied
protective
effect
they
cardiomyocytes
exposed
oxidative
stress
hypoxia/reoxygenation
(H/R)
compared
parent
compound.
An
MTT
assay
was
performed
determine
viability
rat
treated
with
test
compounds.
Trypan
blue
exclusion
lactate
dehydrogenase
(LDH)
release
assays
were
carried
out
study
compounds
cells
H2O2
or
(H/R).
Direct
antioxidant
activity
evaluated
total
capacity
(TAC)
assay.
To
protein
levels,
HO-1,
SOD,
catalase,
Western
blot
analysis
out.
pIC50
(the
negative
log
IC50)
values
as
follows:
CBD1:
4.113,
CBD2:
3.995,
CBD3:
4.190,
CBD:
4.671.
The
newly
synthesized
prevented
cell
death
induced
H/R,
especially
CBD2.
largest
direct
activity.
levels
proteins
increased
differently
after
pretreatment
synthetic
CBD.
Taken
together,
our
are
able
decrease
cytotoxicity
during
H/R.
similar
better
effects
than
H9c2
cells.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1502 - 1502
Published: Nov. 8, 2024
Suk-Saiyasna
is
a
traditional
Thai
herbal
remedy
that
comprises
12
distinct
herbs.
Among
these,
cannabis
leaves
constitute
of
the
total
78
components
in
this
formulation.
This
study
specifically
examines
portion
plant,
which
accounts
for
approximately
15.8%
overall
composition
used
entire
remedy.
According
to
Thailand
Narcotics
Act
2022,
Δ9-tetrahydrocannabinol
(Δ9-THC)
concentration
extracts
must
not
exceed
0.2%
by
weight.
aims
quantify
levels
Δ9-THC
and
cannabidiol
(CBD)
commercial
products.
Foods,
Journal Year:
2024,
Volume and Issue:
13(24), P. 4155 - 4155
Published: Dec. 22, 2024
Hops
(Humulus
lupulus
L.)
are
widely
recognized
for
their
use
in
brewing,
but
they
also
possess
significant
pharmacological
properties
due
to
rich
bioactive
compounds,
with
many
varieties
exhibiting
diverse
characteristics.
This
study
investigates
the
chemical
composition
and
biological
activities
of
extracts
from
six
hop
varieties,
focusing
on
quantifying
xanthohumol
lupulone
using
High-Performance
Liquid
Chromatography
(HPLC)
Total
Phenolic
Content
(TPC)
analysis.
The
demonstrated
variability
compound
concentrations,
Aurora
showing
highest
(0.665
mg/g)
Zwiegniowski
(9.228
mg/g).
TPC
analysis
revealed
had
phenolic
content
(22.47
mg
GAE/g).
Antioxidant
were
evaluated
DPPH,
ABTS,
CUPRAC,
FRAP
assays,
Oregon
Fuggle
displaying
most
potent
capacities.
Aurora,
particular,
showed
activity
across
multiple
including
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
inhibition,
IC50
values
24.39
mg/mL,
20.38
9.37
respectively.
chelating
was
assessed,
Apolon
demonstrating
strongest
metal
ion
binding
capacity
(IC50
=
1.04
mg/mL).
Additionally,
exhibited
effective
hyaluronidase
inhibition
10.27
mg/mL),
highlighting
its
potential
anti-inflammatory
applications.
results
underscore
influence
genetic
environmental
factors
profiles
offering
promising
avenues
pharmaceutical
nutraceutical
However,
further
studies
needed
fully
understand
interactions
between
cones
components.
