Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 142, P. 106957 - 106957

Published: Nov. 5, 2023

Language: Английский

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Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health

Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 797 - 797

Published: March 4, 2024

The issue of lipid changes in muscle foods under the action atmospheric oxygen has captured attention researchers for over a century. Lipid oxidative processes initiate during slaughtering animals and persist throughout subsequent technological processing storage finished product. oxidation lipids is phenomenon extensively deliberated scientific community, acknowledged as one pivotal factors affecting their quality, safety, human health. This review delves into nature foods, highlighting mechanisms free radical initiation propagation processes. Special given to natural antioxidant protective system dietary influencing stability lipids. traces inhibiting processes, exploring how substrates, prooxidant activity, play role. A critical safety meat products provided. impact on quality including flavour, aroma, taste, colour, texture, scrutinised. Additionally, monitors effect oxidised health, particularly relation autooxidation cholesterol. Associations with coronary cardiovascular disease, brain stroke, carcinogenesis linked stress, various infections are discussed. Further studies also needed formulate appropriate solutions reduce risk chemical hazards caused by development peroxidation foods.

Language: Английский

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Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6937 - 6937

Published: June 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Language: Английский

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NiO nanoparticles modified carbon paste electrode for the voltammetric simultaneous detection of catechol and hydroquinone as environmental pollutants

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112578 - 112578

Published: Dec. 1, 2024

Language: Английский

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Mitochondrial dysfunction in Alzheimer’s disease: a key frontier for future targeted therapies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, accounting for approximately 70% of dementia cases worldwide. Patients gradually exhibit cognitive decline, such as memory loss, aphasia, and changes in personality behavior. Research has shown that mitochondrial dysfunction plays a critical role onset progression AD. Mitochondrial primarily leads to increased oxidative stress, imbalances dynamics, impaired mitophagy, genome abnormalities. These abnormalities are closely associated with amyloid-beta tau protein pathology, collectively accelerating process. This review summarizes mitochondria development AD, latest research progress, explores potential mitochondria-targeted therapeutic strategies Targeting mitochondria-related pathways may significantly improve quality life AD patients future.

Language: Английский

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Mitigation of Neuroinflammation and Oxidative Stress in Rotenone-Induced Parkinson Mouse Model through Liposomal Coenzyme-Q10 Intervention: A Comprehensive In-vivo Study

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Parkinson's disease (PD) stands as the sec most prevalent incapacitating neurodegenerative disorder characterized by deterioration of dopamine-producing neurons in substantia nigra. Coenzyme Q10 (CoQ10) has garnered attention a potential antioxidant, anti-inflammatory agent and enhancer mitochondrial complex-I activity. This study aimed to examine compare effectiveness liposomal non-encapsulated CoQ10 rotenone induced-PD mouse model over 21-day treatment duration. 30 mice were divided into 5 equal groups: Group I (mice receiving normal saline), II (rotenone was administered mice), III (standard given IV treated with CoQ10) V Liposomes). Motor performance, preservation dopaminergic neurons, levels neuroinflammation, oxidative stress, neurotransmitter levels, RT-qPCR analysis PD-linked genes histopathology evaluated. The Liposomal group exhibited superior outcomes behavioral tests such reduced anxiety open field test, enhanced balance coordination beam test improved cognitive performance Y-maze test. displayed pronounced antioxidative effects, evidenced significant (p < 0.001) increase superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) activities. In contrast, showed delayed response mitigating inflammation stress. Liposomes demonstrated efficacy 0.0001) restoring dopamine noradrenaline reducing acetylcholinesterase activity, downregulating Synuclein Alpha (SNCA) gene expression (0.722-fold change) compared oral CoQ10, highlighting its suppressing PD symptoms. results this indicated that effectively averted motor impairments, memory lapses, well neuroinflammation triggered rotenone.

Language: Английский

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Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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Complex roles for sulfation in the toxicities of polychlorinated biphenyls

Critical Reviews in Toxicology, Journal Year: 2024, Volume and Issue: 54(2), P. 92 - 122

Published: Feb. 7, 2024

Polychlorinated biphenyls (PCBs) are persistent organic toxicants derived from legacy pollution sources and their formation as inadvertent byproducts of some current manufacturing processes. Metabolism PCBs is often a critical component in toxicity, relevant metabolic pathways usually include initial oxidation to form hydroxylated polychlorinated (OH-PCBs). Subsequent sulfation OH-PCBs was originally thought be primarily means detoxication; however, there strong evidence that it may also contribute toxicities associated with OH-PCBs. These contributions either the direct interaction PCB sulfates receptors or serving localized precursor for The catalyzed by cytosolic sulfotransferases, and, when transported into serum, these metabolites retained, taken up other tissues, subjected hydrolysis intracellular sulfatase(s) regenerate Dynamic cycling between lead further activation resulting Ultimate toxic endpoints such processes endocrine disruption, neurotoxicities, many others exposures This review highlights understanding complex roles can have research on varied mechanisms control roles.

Language: Английский

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Endophytic fungi as a potential source of anti-cancer drug

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)

Published: Feb. 26, 2024

Language: Английский

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Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108771 - 108771

Published: May 22, 2024

Microcystins (MCs) and nitrites are coexisted in the environment have reproductive toxicity. The combined toxic effect mechanism of MCs nitrite on spermatogenesis remain largely unclear. In present study, co-exposure to microcystin-leucine arginine (MC-LR) sodium (NaNO2) aggravated testicular damage Balb/c mice mitochondrial impairment spermatogonia, Sertoli cells, sperm. Furthermore, MC-LR NaNO2 reduced sperm density with a synergistic effect. addition, synergistically induced oxidative stress system by decreasing superoxide dismutase (SOD) activity glutathione (GSH) levels increasing reactive oxygen species (mtROS) (ROS). More importantly, mitoquidone mesylate (MitoQ), an inhibitor mtROS, blocked NaNO2-induced spermatogonia cell apoptosis inhibiting high expression Bax, Fadd, Caspase-8, cleaved-Caspase-3. On other hand, MitoQ suppressed pyroptosis cells NLRP3, N-GSDMD, cleaved-Caspase-1. Additionally, alleviated co-exposure-induced reduction organ index disorders F1 generation mice. Together, can enhance spermatogenic impairment-mediated germ death. This study emphasizes potential risks reproduction realistic environments highlights new insights into cause treatment disorders.

Language: Английский

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