Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseases DOI Creative Commons

Hala Saeed Jaara,

Sandra Torres

Published: Dec. 10, 2024

Mitochondria are essential organelles responsible for intracellular energy production and play crucial roles in cellular metabolism, inflammation, apoptosis. Reactive oxygen species (ROS) primarily produced the mitochondria endoplasmic reticulum of hepatocytes due to activity cytochrome P450 enzymes. Under ideal conditions, cells have specific molecular mechanisms that manage oxidative stress levels, thus ensuring a balance between oxidants antioxidants. The interplay ROS-induced mitochondrial dysfunction activation NLRP3 (nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome context liver diseases has been extensively studied. However, exact by which promote contribute onset disease remain unclear. This review aims elucidate recently discovered regulation disorders, including alcohol-related (ALD), metabolic-associated steatotic (MASLD), hepatocellular carcinoma (HCC). Finally, it summarizes various natural pharmaceutical agents can mitigate damage modulating through pathways. work serves as an important resource identifying new therapeutic approaches provides further support advancing understanding diseases.

Language: Английский

Oxidative stress modulation in alcohol-related liver disease: From chinese botanical drugs to exercise-based interventions DOI Creative Commons
Yuting Zhu,

Yuqing Jia,

Enming Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Alcohol-related liver disease (ALD) is a chronic injury caused by long-term excessive alcohol consumption, with complex and multifaceted pathological mechanisms. Research indicates that oxidative stress (OS), inflammatory responses, lipid metabolic disturbances induced its metabolites are primary contributors to hepatocyte injury, positioning OS as key target in ALD treatment. The main non-pharmacological treatment for abstinence, while medical primarily relies on Western pharmacological interventions. However, recent research has increasingly highlighted the potential of Chinese botanical drugs improving histological features modulating signaling pathways associated ALD, underscoring therapeutic traditional herb medicine. Despite these promising findings, precise mechanisms effects extracts remain incompletely understood, side must be considered. Therefore, comprehensive analysis herbal essential optimize clinical administration ensure safe, effective This review focuses central theme, categorizing into six major groups—flavonoids, polyphenols, terpenoids, alkaloids, saponins, anthraquinones—all widely used provides an overview their characteristics actions context offering insights regulation exploring treatments ALD. Notably, physical exercise shares overlapping regulating OS. Combining two strategies could offer integrative though further needed confirm synergistic benefits applications.

Language: Английский

Citations

0
Reveal the mechanism of hepatic oxidative stress in mice induced by photo-oxidation milk using multi-omics analysis techniques DOI Creative Commons

Sijia Tan,

Qiangqiang Li, Can Guo

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Photo-oxidation is recognized as a contributor to the deterioration of milk quality, posing potential safety hazards human health. However, there has been limited investigation into impact consuming photo-oxidized on

Language: Английский

Citations

3
Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota DOI Creative Commons
Yan Yan, Hai‐Sheng Yuan, Fan Yang

et al.

AMB Express, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

Citations

3
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway DOI Creative Commons
Qi Tan,

Qifeng He,

Ze Peng

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 20, 2024

Abstract Background Type 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise consequential complications that arise as a result of T2DM. To investigate, db/db mice were used for the disease model. The findings demonstrated scaffold made from combination rhubarb charcoal-crosslinked chitosan silk fibroin, designated RCS/SF, was able improve healing process diabetic wounds in mice. However, previous studies have primarily concentrated on investigating impacts RSC/SF wound only, while its influence entire body has not been fully elucidated. Material methods fibroin/chitosan sponge containing charcoal fabricated present study using freeze-drying approach. Subsequently, an incision with diameter 8 mm dorsal skin mice, RCS/SF applied directly 14 days. impact therapy hepatic metabolism assessed through analysis serum liver biochemistry, histopathology, quantitative real-time PCR (qRT-PCR), immunohistochemistry, Western blotting. Results use led enhancement conditions associated glucolipid An assessment histopathology further confirmed this enhancement. Additionally, qRT-PCR revealed treatment resulted downregulation genes fatty acid synthesis, uptake, triglyceride (TG) gluconeogenesis, inflammatory factors. Moreover, beneficial effect oxidative stress shown assessing antioxidant enzymes peroxidation. network pharmacology verified adenosine monophosphate-activated protein kinase (AMPK) signalling pathway had vital function mitigating non-alcoholic (NAFLD) utilizing R. officinale. measurement AMPK, sterol regulatory element binding 1 (SREBP1), synthase (FASN), acetyl CoA carboxylase (ACC) gene expression provided support discovery. Furthermore, molecular docking investigations robust affinity between active components downstream targets AMPK (SREBP1 FASN). Conclusion By regulating pathway, topically effectively mitigated accumulation, decreased inflammation, attenuated stress. study, therefore, emphasises crucial role topical thereby confirming concept "external internal reshaping".

Language: Английский

Citations

2
Is periodontitis triggering an inflammatory response in the liver, and does this reaction entail oxidative stress? DOI
Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Harishkumar Madhyastha

et al.

Odontology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Citations

2
Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies DOI Open Access
Evelyn Angie, Ermi Girsang, Refi Ikhtiari

et al.

Jurnal Penelitian Pendidikan IPA, Journal Year: 2024, Volume and Issue: 10(6), P. 2898 - 2905

Published: June 20, 2024

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from insulin deficiency or resistance. Streptozotocin, potent diabetogenic agent, commonly employed to induce experimental diabetes selectively damaging pancreatic beta cells, in and hyperglycemia. Elevated Malondialdehyde (MDA) levels, indicative of oxidative stress lipid peroxidation, are closely linked diabetic complications. This study aimed investigate the association between MDA Streptozotocin-induced rat diabetes, shedding light on potential therapeutic strategies. Spectrophotometric analysis was utilized quantify tissues, providing insights into extent damage. The results revealed significant correlation glucose, highlighting role pathogenesis. These findings underscore importance targeting management prevent In conclusion, emphasizes relevance monitoring as biomarker for assessing conditions guiding interventions.

Language: Английский

Citations

1
Enhancing antioxidant levels and mitochondrial function in porcine oocyte maturation and embryonic development through notoginsenoside R1 supplementation DOI

Sheng‐Yan He,

Wen Liu,

Chu‐Man Huang

et al.

Reproduction in Domestic Animals, Journal Year: 2024, Volume and Issue: 59(6)

Published: June 1, 2024

Abstract This study examines the impact of Notoginsenoside R1 (NGR1), a compound from Panax notoginseng , on maturation porcine oocytes and their embryonic development, focusing its effects antioxidant levels mitochondrial function. demonstrates that supplementing in vitro (IVM) medium with NGR1 significantly enhances several biochemical parameters. These include elevated glutathione (GSH), nuclear factor erythrocyte 2‐related 2 ( NRF2 ) mRNA expression catalase CAT GPX . Concurrently, we observed decrease reactive oxygen species (ROS) an increase JC‐1 immunofluorescence, distribution, peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC1α) levels. Additionally, there was ATP production lipid droplets (LDs) immunofluorescence. improvements correlate enhanced outcomes, including higher blastocyst rate, increased total cell count, proliferative capacity octamer‐binding transcription 4 Oct4 superoxide dismutase Sod2 gene expression. Furthermore, supplementation resulted decreased apoptosis, reduced caspase 3 Cas3 BCL2‐Associated X Bax glucose‐regulated protein 78 kD (GRP78) immunofluorescence undergoing maturation. findings suggest plays crucial role promoting oocyte subsequent development by providing protection.

Language: Английский

Citations

0
Nrf2: The Guardian of Cellular Harmony – Unveiling Its Role in Cell Biology and Senescence DOI
Mai A. Samak

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Nrf2, a key cellular regulator, plays complex and multifaceted role in both protecting healthy cells potentially promoting disease progression. This chapter delves into the intricate mechanisms by which Nrf2 exerts its protective effects, including combating carcinogens, maintaining integrity, inducing controlled cell death under severe stress. However, also explores “dark side” of where activity cancer can contribute to chemoresistance, adaptation, growth, hindering effective treatment. The further investigates current research avenues for harnessing Nrf2’s potential therapeutic benefit. Strategies activation inhibition are explored, highlighting importance context-dependent balancing protection harm, minimizing off-target effects. Promising new directions, such as developing tissue-specific modulators, identifying predictive biomarkers, combining modulators with other approaches, discussed. By understanding roles, we pave way development safer more strategies that leverage beneficial effects while mitigating drawbacks various diseases.

Language: Английский

Citations

0
Rosemary officinalis extract mitigates potassium dichromate-induced testicular degeneration in male rats: Insights from the Nrf2 and its target genes signaling pathway DOI Creative Commons
Ahmed M. Nagy, Mohamed F. Abdelhameed,

Shaimaa Rihan

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101700 - 101700

Published: July 24, 2024

This study aimed to investigate the protective effects of Rosemary ethanol extract (ROEE) on testicular damage induced by potassium Dichromate (PDC) in male rats regarding signaling pathway Nrf2 and its target genes proteins. A total 28 were divided into four groups: control, PDC only (15 mg/kg b.w. orally), + low dose ROEE (220 b.w.), high (440 b.w.). After days consecutive treatment, sacrificed for histological, immunohistochemistry, biochemical analyses. The results revealed that treatment up-regulated (NQO1, HO-1) mRNA expressions compared group. correspondingly, protein levels GCLM, GSH, SOD, catalase significantly increased ROEE-treated animals PDC-treated animals. Furthermore, administration led serum testosterone (T4) decreased estrogen (E2) Semen analysis histopathology demonstrated improved spermatological impairment caused PDC. immunoexpression cytoplasmic HSP-90 was reduced groups, while expression androgen receptor (AR) markedly improved. exhibited against PDC-induced damage, likely due antioxidant properties. However, further investigation is required elucidate underlying mechanisms action.

Language: Английский

Citations

0
Mechanisms of Metal-Induced Hepatic Inflammation DOI

Nivetha Subramaniam,

Koren K. Mann

Current Environmental Health Reports, Journal Year: 2024, Volume and Issue: 11(4), P. 547 - 556

Published: Nov. 5, 2024

Language: Английский

Citations

0