Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Poly(amidoamine)
(PAMAM)
dendrimers
have
gained
significant
attention
in
various
research
fields,
particularly
medicinal
compound
delivery.
Their
versatility
lies
their
ability
to
conjugate
with
functional
molecules
on
surfaces
and
encapsulate
small
molecules,
making
them
suitable
for
diverse
applications.
Gallic
acid
is
a
potent
antioxidant
that
has
garnered
considerable
interest
recent
years.
Our
aims
investigate
if
the
gallic
acid-encapsulated
PAMAM
dendrimer
generations
4
(G4(OH)-Ga)
5
(G5(OH)-Ga)
could
enhance
radical
scavenging,
which
potentially
slow
down
progression
of
age-related
macular
degeneration
(AMD).
Encapsulation
feasible
alternative
prevent
its
degradation
toxicity.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3609 - 3609
Published: March 23, 2024
The
retinal
pigment
epithelium
(RPE),
which
ensures
the
normal
functioning
of
neural
retina,
is
a
pigmented
single-cell
layer
that
separates
retina
from
Bruch's
membrane
and
choroid.
There
are
three
main
types
granules
in
RPE
cells
human
eye:
lipofuscin
(LG)
containing
fluorescent
"age
pigment"
lipofuscin,
melanoprotein
(melanosomes,
melanolysosomes)
screening
melanin
complex
melanolipofuscin
(MLG)
both
pigments
simultaneously-melanin
lipofuscin.
This
review
examines
functional
role
aging
process
development
oxidative
stress
associated
pathologies
cells.
focus
on
light-induced
degradation
caused
by
reactive
oxygen
species.
reasons
leading
to
increased
as
result
considered.
A
mechanism
proposed
explain
phenomenon
age-related
decline
content
essence
when
part
granule
exposed
light,
species
formed,
destroy
part.
As
more
formed
with
age
degenerative
diseases,
epithelial
ultimately
disappears.
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(6), P. 2472 - 2509
Published: May 6, 2024
Previously,
lysosomes
were
primarily
referred
to
as
the
digestive
organelles
and
recycling
centers
within
cells.
Recent
discoveries
have
expanded
lysosomal
functional
scope
revealed
their
critical
roles
in
nutrient
sensing,
epigenetic
regulation,
plasma
membrane
repair,
lipid
transport,
ion
homeostasis,
cellular
stress
response.
Lysosomal
dysfunction
is
also
found
be
associated
with
aging
several
diseases.
Therefore,
function
of
macroautophagy,
a
lysosome-dependent
intracellular
degradation
system,
has
been
identified
one
updated
twelve
hallmarks
aging.
In
this
review,
we
begin
by
introducing
concept
quality
control
(LQC),
which
machinery
that
maintains
number,
morphology,
through
different
processes
such
biogenesis,
reformation,
fission,
fusion,
turnover,
lysophagy,
exocytosis,
permeabilization
repair.
Next,
summarize
results
from
studies
reporting
association
between
LQC
dysregulation
aging/various
disorders.
Subsequently,
explore
emerging
therapeutic
strategies
target
distinct
aspects
for
treating
diseases
combatting
Lastly,
underscore
existing
knowledge
gap
propose
potential
avenues
future
research.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(10), P. 1647 - 1647
Published: Oct. 8, 2024
The
most
prevalent
reason
for
vision
impairment
in
aging
inhabitants
is
age-related
macular
degeneration
(AMD),
a
posterior
ocular
disease
with
poor
understanding
of
the
anatomic,
genetic,
and
pathophysiological
progression
disease.
Recently,
new
insights
exploring
role
atrophic
changes
retinal
pigment
epithelium,
extracellular
drusen
deposits,
lysosomal
lipofuscin,
various
genes
have
been
investigated
AMD.
Hence,
this
review
explores
incidence
risk
factors
AMD,
such
as
oxidative
stress,
inflammation,
complement
system,
involvement
bioactive
lipids
their
angiogenesis.
In
addition
to
intravitreal
anti-vascular
endothelial
growth
factor
(VEGF)
therapy
other
therapeutic
interventions
oral
kinase
inhibitors,
photodynamic,
gene,
antioxidant
therapy,
well
benefits
drawbacks
AMD
treatment
options,
strategic
drug
delivery
methods,
including
routes
focus
on
pharmacokinetics,
are
investigated.
Further,
recent
advancements
nanoformulations
polymeric
lipid
nanocarriers,
liposomes,
etc.,
intended
pros
cons
too
summarized.
Therefore,
purpose
give
researchers
an
pathophysiology,
emphasis
angiogenesis,
function
lipids,
options.
Additionally,
options
that
development
system(s)
via
several
can
aid
advancement
choices.
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(12), P. 20 - 20
Published: Oct. 15, 2024
Age-related
macular
degeneration
(AMD)
stands
as
a
leading
cause
of
severe
visual
impairment
and
blindness
among
the
elderly
globally.
As
multifactorial
disease,
AMD's
pathogenesis
is
influenced
by
genetic,
environmental,
age-related
factors,
with
lipid
metabolism
abnormalities
complement
system
dysregulation
playing
critical
roles.
This
review
delves
into
recent
advancements
in
understanding
intricate
interaction
between
these
two
crucial
pathways,
highlighting
their
contribution
to
disease's
progression
through
chronic
inflammation,
drusen
formation,
retinal
pigment
epithelium
dysfunction.
Importantly,
emerging
evidence
points
dysregulated
profiles,
particularly
alterations
high-density
lipoprotein
levels,
oxidized
deposits,
intracellular
lipofuscin
accumulation,
exacerbating
factors
that
enhance
activation
subsequently
amplify
tissue
damage
AMD.
Furthermore,
genetic
studies
have
revealed
significant
associations
AMD
specific
genes
involved
transport
regulation,
shedding
light
on
disease
susceptibility
underlying
mechanisms.
The
further
explores
clinical
implications
findings,
advocating
for
novel
therapeutic
approach
integrates
modulators
inhibitors.
By
concurrently
targeting
dual-targeted
holds
promise
significantly
improving
outcomes
patients,
heralding
new
horizon
management
treatment.
Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Retinal
diseases
are
a
leading
cause
of
vision
loss,
affecting
millions
people
worldwide.
Current
treatment
options
based
on
invasive
methods
such
as
intravitreal
injections.
Therefore,
there
is
need
for
alternative
therapeutic
strategies
that
both
effective
and
more
patient-friendly.
Topical
drug
delivery
has
gained
attention
preferred
noninvasive
approach,
although
it
hindered
by
several
ocular
barriers.
Cyclodextrin
(CD)-based
nanoparticles
have
emerged
promising
strategy
to
overcome
these
limitations
enhancing
permeability
in
the
posterior
segment
eye.
This
review
discusses
potential
CDs
enabling
pharmaceutical
excipients,
their
role
improving
bioavailability,
provides
examples
CD-based
eye
drop
formulations
currently
under
development
or
undergoing
clinical
trials.
Also,
active
agents
ophthalmology
discussed.
nanoparticle
drops
present
solution
shown
success.
approved
excipients
can
act
ingredients
inherent
retinal
diseases.
Future
innovations
hybrid
systems
integration
novel
compounds
could
provide
efficient
targeted
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 9, 2024
Brain
metabolism
is
essential
for
the
function
of
organisms.
While
established
imaging
methods
provide
valuable
insights
into
brain
metabolic
function,
they
lack
resolution
to
capture
important
interactions
and
heterogeneity
at
cellular
level.
Label-free,
two-photon
excited
fluorescence
addresses
this
issue
by
enabling
dynamic
assessments
single-cell
level
without
manipulations.
In
study,
we
demonstrate
impact
spectral
on
development
rigorous
intensity
lifetime
label-free
protocols
assess
dynamically
over
time
in
3D
engineered
tissue
models
comprising
human
induced
neural
stem
cells,
astrocytes,
microglia.
Specifically,
rely
multi-wavelength
identify
excitation/emission
profiles
key
fluorophores
within
including
NAD(P)H,
LipDH,
FAD,
lipofuscin.
These
enable
mitigate
lipofuscin's
overlap
with
NAD(P)H
flavin
autofluorescence
extract
reliable
optical
metrics
from
images
acquired
two
excitation
wavelengths
emission
bands.
We
present
reporting
redox
state,
mitochondrial
fragmentation,
binding
status
neuronal
monoculture
triculture
systems,
highlight
functional
between
different
cell
types.
Our
findings
reveal
significant
differences
neurons
glial
shedding
light
pathway
utilization,
glutathione
pathway,
OXPHOS,
glycolysis,
fatty
acid
oxidation.
Collectively,
our
studies
establish
a
label-free,
non-destructive
approach
among
types
relying
endogenous
illustrate
complementary
nature
information
that
gained
combining
lifetime-based
images.
Such
can
improve
understanding
physiological
dysfunction
occurs
onset
cancers,
traumatic
injuries
neurodegenerative
diseases.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(16)
Published: Aug. 19, 2024
Abstract
Since
the
12
major
signs
of
aging
were
revealed
in
2023,
people's
interpretation
will
go
further,
which
is
great
significance
for
understanding
occurrence,
development,
and
intervention
process.
As
one
aging,
cellular
senescence
refers
to
process
proliferation
differentiation
ability
cells
decrease
under
stress
stimulation
or
over
time,
often
manifested
as
changes
cell
morphology,
cycle
arrest,
decreased
metabolic
function.
Interferon
(IFN),
a
secreted
ligand
specific
surface
receptors,
can
trigger
transcription
interferon‐stimulated
genes
(ISGs)
play
an
important
role
senescence.
In
addition,
IFN
serves
component
SASP,
activation
signaling
pathway
has
been
shown
contribute
apoptosis
It
expected
delay
by
linking
with
studying
effects
on
its
mechanism.
This
article
provides
review
research
relationship
between
consulting
relevant
literature.
