Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model DOI Creative Commons
Jie Ding, Jiahui Liu,

Qingqi Guo

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 35 - 35

Published: Dec. 30, 2024

This study investigates the anti-aging effects of various concentrations blueberry anthocyanins (BA) on lifespan and health-related phenotypes Caenorhabditis elegans. Blueberry were administered at 50.0 μg/mL, 200.0 500.0 their nematode lifespan, locomotion, pharyngeal pumping rate, accumulation lipofuscin reactive oxygen species (ROS) examined. Transcriptomic analysis was conducted to explore regulatory BA molecular pathways key genes in C. Results showed a significant, dose-dependent extension improvement locomotion reduction ROS accumulation. revealed that activated such as FOXO, IIS, PI3K/Akt, upregulating critical like daf-16. These findings highlight potential promising agents through multiple physiological mechanisms.

Language: Английский

Harnessing two-dimensional magnetic Poly(deep eutectic solvents) for matrix solid-phase dispersion extraction of polyphenols from roselle: Promoting antiphotoaging strategy DOI
Lan Wang,

Mingxi Li,

Yan Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154019 - 154019

Published: July 19, 2024

Language: Английский

Citations

11
Cutting-edge developments in the application of hydrogels for treating skin photoaging DOI Creative Commons
Lili Cao,

Xiaoying Qian,

Jie Min

et al.

Frontiers in Materials, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 30, 2024

Skin photoaging, caused by prolonged exposure to ultraviolet (UV) radiation, manifests as intricate biological transformations, encompassing oxidative damage and structural alterations. Despite a growing need for effective interventions, the existing therapeutic repertoire treating skin photoaging remains constrained. Recent investigations have shifted focus towards application of hydrogels novel avenue addressing this concern. Various active substances can be combined with transdermal delivery, including compounds from ocean, plants, cell substances, which promote UV repair mainly through antioxidant, anti-inflammatory collagen production. This review seeks offer thorough summary recent progress in employing photoaging. Topics covered include mechanism emerging trends hydrogel-based therapies rejuvenation. The discussion also explores challenges outlines potential future directions leveraging agents address

Language: Английский

Citations

2
Tailoring biomaterials for skin anti-aging DOI Creative Commons

Xin Dan,

Songjie Li, Han Chen

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101210 - 101210

Published: Aug. 28, 2024

Skin aging is the phenomenon of degenerative changes in structure and function skin tissues over time manifested by a gradual loss elasticity firmness, an increased number wrinkles, hyperpigmentation. anti-aging refers to reduction through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving appearance mechanical tissue filling, regulating collagen synthesis degradation, inhibiting pigmentation, repairing barrier. This review summarizes mechanisms associated with aging, describes that are commonly used aesthetics their possible modes action, discusses application strategies this area. Moreover, synergistic effects such other active ingredients, as stem cells, exosomes, growth factors, antioxidants, on regeneration evaluated. Finally, challenges development prospects field discussed, novel ideas future innovations area summarized.

Language: Английский

Citations

1
Vaccinium Species—Unexplored Sources of Active Constituents for Cosmeceuticals DOI Creative Commons
Wirginia Kukuła‐Koch, Natalia Dycha, Paulina Lechwar

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1110 - 1110

Published: Sept. 3, 2024

The genus

Language: Английский

Citations

1
Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model DOI Creative Commons
Jie Ding, Jiahui Liu,

Qingqi Guo

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 35 - 35

Published: Dec. 30, 2024

This study investigates the anti-aging effects of various concentrations blueberry anthocyanins (BA) on lifespan and health-related phenotypes Caenorhabditis elegans. Blueberry were administered at 50.0 μg/mL, 200.0 500.0 their nematode lifespan, locomotion, pharyngeal pumping rate, accumulation lipofuscin reactive oxygen species (ROS) examined. Transcriptomic analysis was conducted to explore regulatory BA molecular pathways key genes in C. Results showed a significant, dose-dependent extension improvement locomotion reduction ROS accumulation. revealed that activated such as FOXO, IIS, PI3K/Akt, upregulating critical like daf-16. These findings highlight potential promising agents through multiple physiological mechanisms.

Language: Английский

Citations

1