Antioxidants in Inflammatory Diseases DOI Creative Commons

Sayed Mohammed Firdous,

Sourav Pal, Subhajit Mandal

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 126

Published: Nov. 17, 2024

Damage to tissues and abnormal function of organs are hallmarks inflammatory disorders, which characterized by an overactive inadequately controlled immune response. Inflammation chronic diseases can result from microbial infections, tissue damage, autoimmune dysregulation. These stimuli trigger macrophages neutrophils, releasing ROS RNS. ROS/RNS overwhelm the body's antioxidant defenses, causing oxidative assault signaling cascades. NF-кβ AP-1 activate amid assault. transcription factors regulate expression pro-inflammatory genes that create cytokines (TNF, ILs), chemokines, adhesion molecules, enhance inflammation recruit cells damaged areas. Antioxidants oversight several They're able block production pro- reducing activation. Crucial MAPK pathways like ERK, JNK, p38 be modulated antioxidants. decrease mediator synthesis because they interfere with these pathways. Directly scavenging neutralizing is how antioxidants do their job. Scavenging protects lipids, proteins, DNA against damage. SOD, catalase, glutathione peroxidase, body-produced enzymes. Thus, increasing enzyme activity strengthens cells' defenses. induce anti-inflammatory phenotype in T cells. They capable shifting M1 M2. M2 aid repair immunomodulation. also promote formation regulatory cells, system inhibiting other In conclusion, this abstract emphasizes crucial role potential as therapeutic agents.

Language: Английский

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review DOI Creative Commons
Maroua Jalouli, Md. Ataur Rahman, Partha Biswas

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

Citations

5

Effect of Saccharomyces cerevisiae CICC 32883 Fermentation on the Structural Features and Antioxidant Protection Effect of Chinese Yam Polysaccharide DOI Creative Commons
Zichao Wang,

Yi Zheng,

Ziru Lai

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 564 - 564

Published: Feb. 8, 2025

In this study, Chinese yam polysaccharide (CYP) was fermented by Saccharomyces cerevisiae CICC 32883, and its structural features antioxidant activities before after fermentation were analyzed. S. 32883-fermented CYP (CYP-SC) had higher carbohydrate content lower protein than the nonfermented (CYP-NF). The monosaccharide composition of CYP-SC unaffected, but proportion changed. Compared with CYP-NF's molecular weight polydispersity 124.774 kDa 6.58, respectively, those reduced to 20.384 3.379. Antioxidant results showed that better effects CYP-NF in scavenging DPPH, ABTS, hydroxyl, superoxide radicals. Moreover, enhancing oxidation capacity protecting HepG2 cells CYP-NF. Furthermore, on alleviating repairing H2O2-damaged are superior This work offers a green efficient method for activity dietary plant polysaccharides.

Language: Английский

Citations

3

Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review DOI
Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

1

Nanotechnology and flavonoids: Current research and future perspectives on cardiovascular health DOI Creative Commons
Rony Abdi Syahputra, Aminah Dalimunthe,

Zahirah Dyiah Utari

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 120, P. 106355 - 106355

Published: July 26, 2024

Language: Английский

Citations

6

Mechanistic Insights into the Biological Effects and Antioxidant Activity of Walnut (Juglans regia L.) Ellagitannins: A Systematic Review DOI Creative Commons
Letiția Mateș, Roxana Banc,

Flaviu Andrei Zaharie

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 974 - 974

Published: Aug. 10, 2024

Walnuts (

Language: Английский

Citations

5

Sustainable Extraction of Bioactive Compounds and Nutrients from Agri-Food Wastes: Potential Reutilization of Berry, Honey, and Chicory Byproducts DOI Creative Commons
Gregorio Peron, Irene Ferrarese, Nadia Alessandra Carmo Dos Santos

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 10785 - 10785

Published: Nov. 21, 2024

Several agri-food byproducts represent valuable sources of compounds to be reutilized for nutritional, nutraceutical, and cosmetic purposes. Examples especially comprise from the processing fruits such as pomace, because their richness in nutrients (e.g., fibers) bioactive polyphenols) that can destined animal human use. However, agreement with principles circular economy are being promoted during most recent years, other understudied both plant origin evaluated assess possible reutilization valorization. In this review, we aim at summarizing research dealing extraction using innovative sustainable approaches. Specifically, review is focused on generated large amounts (tons/year) by food industry Northeast Italy, namely, honey, red (grapes berries), chicory, which interest content phenolic acids, flavonoids, anthocyanins, dietary fiber. The potential applications these extracts cosmetic, nutritional fields also discussed, referring published literature, well utilization novel pharmacological applications.

Language: Английский

Citations

4

Exploring the Role of Edible Dock Powder (Rumex K-1) in Enhancing Growth Performance, Organ Health, and Cecal Microbiota in Sanhua Goslings DOI Creative Commons
Xianze Wang,

Junliang Wang,

Yi Liu

et al.

Agriculture, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 6, 2025

This study investigated the effects of dietary Edible Dock Powder (EDP) on growth performance, organ development, serum biochemistry, and cecal microbiota in Sanhua goslings. A total 240 goslings were randomly allocated into four groups: one control group (Group A) three experimental groups supplemented with EDP at concentrations 1.00% B), 2.50% C), 4.00% D). Group B showed a significantly decreased feed-to-gain ratio (F/G) compared to (p < 0.05). Organ analysis indicated an increase liver glandular stomach weights Groups C Serum aspartate transaminase (AST) levels 0.05), glucose (GLU) notably lower D Cecal revealed that was enriched Prevotella Streptococcaceae, while Cyanobacteria Alistipes higher C. Additionally, Desulfovibrio positively correlated weight, Oxalobacter ADG These findings suggest 1.00–2.50% supplementation supports growth, enhances gut health, optimizes composition, providing viable functional feed strategy for

Language: Английский

Citations

0

Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders DOI
Abdulmajeed G. Almutary, M. Yasmin Begum,

Ayesha Siddiqua

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0

Bioinformatic and experimental approaches to uncover the bio-potential of Mercurialis annua extracts based on chemical constituents DOI
Mehmet Veysi Çetiz,

Shakeel Ahmed,

Gokhan Zengin

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127390 - 127390

Published: March 1, 2025

Language: Английский

Citations

0

Application of polyphenols as natural antioxidants in edible oils: Current status, antioxidant mechanism, and advanced technology DOI
Yujie Zhong,

Xinyu Yuan,

Qiqi Feng

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116234 - 116234

Published: March 1, 2025

Language: Английский

Citations

0