Non-Invasive Endometrial Cancer Screening through Urinary Fluorescent Metabolome Profile Monitoring and Machine Learning Algorithms DOI Open Access
Monika Švecová, Katarı́na Dubayová, Anna Birková

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3155 - 3155

Published: Sept. 14, 2024

Endometrial cancer is becoming increasingly common, highlighting the need for improved diagnostic methods that are both effective and non-invasive. This study investigates use of urinary fluorescence spectroscopy as a potential tool endometrial cancer. Urine samples were collected from patients (n = 77), with benign uterine tumors 23), control gynecological attending regular checkups or follow-ups 96). These analyzed using synchronous to measure total fluorescent metabolome profile, specific ratios created differentiate between control, benign, malignant samples. spectral markers demonstrated clinical applicability AUC high 80%. Partial Least Squares Discriminant Analysis (PLS-DA) was employed reduce data dimensionality enhance class separation. Additionally, machine learning models, including Random Forest (RF), Logistic Regression (LR), Support Vector Machine (SVM), Stochastic Gradient Descent (SGD), utilized distinguish controls patients. PLS-DA achieved an overall accuracy 79% 90%. promising results indicate spectroscopy, combined advanced has revolutionize diagnostics, offering rapid, accurate, non-invasive alternative current methods.

Language: Английский

Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy DOI Creative Commons

Bemrew Admassu Mengistu,

Tirunesh Tsegaw,

Yitayew Demessie

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Cancer remains a significant global challenge, and despite the numerous strategies developed to advance cancer therapy, an effective cure for metastatic elusive. A major hurdle in treatment success is ability of cells, particularly stem cells (CSCs), resist therapy. These CSCs possess unique abilities, including self-renewal, differentiation, repair, which drive tumor progression chemotherapy resistance. The resilience linked certain signaling pathways. Tumors with pathway-dependent often develop genetic resistance, whereas those pathway-independent undergo epigenetic changes that affect gene regulation. can evade cytotoxic drugs, radiation, apoptosis by increasing drug efflux transporter activity activating survival mechanisms. Future research should prioritize identification new biomarkers molecules better understand use cutting-edge approaches, such as bioinformatics, genomics, proteomics, nanotechnology, offers potential solutions this challenge. Key include developing targeted therapies, employing nanocarriers precise delivery, focusing on CSC-targeted pathways Wnt, Notch, Hedgehog Additionally, investigating multitarget inhibitors, immunotherapy, nanodrug delivery systems critical overcoming resistance cells.

Language: Английский

Citations

7
Pharmacologic Ascorbate Resistant Pancreatic Cancer Demonstrates Enhanced Metastatic Potential DOI
Amanda N. Pope,

Brianne R. O apos Leary,

Juan Du

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Static magnetic field promotes the doxorubicin toxicity effects on osteosarcoma cells DOI Creative Commons
Fatemeh Rajabi, Behnam Hajipour‐Verdom, Parviz Abdolmaleki

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 7, 2025

Language: Английский

Citations

0
Redox Balance in Cancer in the Context of Tumor Prevention and Treatment DOI Creative Commons
Paweł Sutkowy, Przemysław Czeleń

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1149 - 1149

Published: May 9, 2025

Malignant neoplasms constitute a substantial health concern for the human population, currently ranking as second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise 35 in 2050. Consequently, development effective cancer treatments prevention strategies remains primary focus medical research. context, impacts on redox balance are being considered. The objective study was present current knowledge oxidation reduction processes cancer. This review discloses intricate multifaceted interplay oxidoreductive systems during carcinogenesis, which engenders discordant findings domain tumor treatment. also examines controversies surrounding use antioxidants, including their impact other therapeutic interventions. offers comprehensive overview existing subject, concluding personalized precise anticancer therapies targeting can serve both diagnostic tools.

Language: Английский

Citations

0
Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer DOI Creative Commons

Danyao Chen,

Ziyu Guo, Lei Yao

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103686 - 103686

Published: May 1, 2025

Reactive oxygen species (ROS), regulators of cellular behaviors ranging from signaling to cell death, have complex production and control mechanisms maintain a dynamic redox balance under physiological conditions. Redox imbalance is frequently observed in tumor cells, where ROS within tolerable limits promote oncogenic transformation, while excessive induce range regulated death (RCD). As such, targeting ROS-mediated as vulnerability cancer. However, the precise regulatory networks governing cancer their therapeutic applications remain inadequately characterized. In this Review, we first provide comprehensive overview underlying highlighting balance. Next, discuss paradoxical nature system can growth or suppress it, depending on context. We also systematically explored role pathways revealed cross-linking cells. Following this, focus intricate regulation RCD its current therapy. further summarize potential ROS-induced RCD-based therapies, particularly those mediated by drugs specific mechanisms. Finally, address measurement oxidative damage research, discussing existing challenges future prospects hope review will offer promise for clinical application stress-mediated

Language: Английский

Citations

0
Pharmacologic Ascorbate Resistant Pancreatic Cancer Demonstrates Enhanced Metastatic Potential DOI Creative Commons
Amanda N. Pope, Brianne R. O’Leary, Juan Du

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 84, P. 103694 - 103694

Published: May 21, 2025

Language: Английский

Citations

0
Non-Invasive Endometrial Cancer Screening through Urinary Fluorescent Metabolome Profile Monitoring and Machine Learning Algorithms DOI Open Access
Monika Švecová, Katarı́na Dubayová, Anna Birková

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3155 - 3155

Published: Sept. 14, 2024

Endometrial cancer is becoming increasingly common, highlighting the need for improved diagnostic methods that are both effective and non-invasive. This study investigates use of urinary fluorescence spectroscopy as a potential tool endometrial cancer. Urine samples were collected from patients (n = 77), with benign uterine tumors 23), control gynecological attending regular checkups or follow-ups 96). These analyzed using synchronous to measure total fluorescent metabolome profile, specific ratios created differentiate between control, benign, malignant samples. spectral markers demonstrated clinical applicability AUC high 80%. Partial Least Squares Discriminant Analysis (PLS-DA) was employed reduce data dimensionality enhance class separation. Additionally, machine learning models, including Random Forest (RF), Logistic Regression (LR), Support Vector Machine (SVM), Stochastic Gradient Descent (SGD), utilized distinguish controls patients. PLS-DA achieved an overall accuracy 79% 90%. promising results indicate spectroscopy, combined advanced has revolutionize diagnostics, offering rapid, accurate, non-invasive alternative current methods.

Language: Английский

Citations

2