NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation DOI Open Access
Evan L. Carpenter, Alyssa L. Becker, Arup K. Indra

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(6), P. 1531 - 1531

Published: March 16, 2022

Melanocytes are dendritic, pigment-producing cells located in the skin and responsible for its protection against deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments distributing them to adjacent (e.g., keratinocytes). However, melanocytes encounter a large burden oxidative stress during this process, due both exogenous endogenous sources. Therefore, employ numerous antioxidant defenses protect themselves; these largely regulated master response transcription factor, nuclear factor erythroid 2-related 2 (NRF2). Key effector transcriptional targets NRF2 components glutathione thioredoxin systems. Despite defenses, melanocyte often is subject mutations that result dysregulation proliferative mitogen-activated protein kinase (MAPK) pathway cell cycle. Following tumor initiation, systems co-opted, consequence caused metabolic reprogramming, establish an altered redox homeostasis. This homeostasis contributes progression metastasis, while also complicating application treatments. Further understanding homeostasis, presence or absence disease, would contribute development novel therapies aid prevention treatment melanomas other diseases

Language: Английский

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways DOI Creative Commons
J. Catharina Duvigneau, Harald Esterbauer, Andrey V. Kozlov

et al.

Antioxidants, Journal Year: 2019, Volume and Issue: 8(10), P. 475 - 475

Published: Oct. 11, 2019

The heme oxygenase (HO) system is essential for and iron homeostasis necessary adaptation to cell stress. HO degrades biliverdin (BV), carbon monoxide (CO) ferrous iron. Although mostly beneficial, the reaction can also produce deleterious effects, predominantly attributed excessive product formation. Underrated so far is, however, that may exert effects additionally via modulation of cellular levels. Heme, besides being an often-quoted generator oxidative stress, plays important role as a signaling molecule. Heme controls anti-oxidative defense, circadian rhythms, activity ion channels, glucose utilization, erythropoiesis, macrophage function. This broad spectrum depends on its interaction with proteins ranging from transcription factors enzymes. In degrading heme, has potential heme-mediated pathways. this review, we will discuss multitude pathways regulated by enlarge view in physiology. We further highlight contribution pathophysiology, which results dysregulated balance between degradation products formed HO.

Language: Английский

Citations

86
Iron Metabolism in Cancer Progression DOI Open Access
Stefania Forciniti, Luana Greco, Fabio Grizzi

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 2257 - 2257

Published: March 24, 2020

Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter, several disruptions its occur at steps tumor initiation, progression metastasis. Noticeably, cells require a large amount iron, exhibit strong dependence on it their proliferation. Numerous iron metabolism-related proteins signaling pathways are altered by in malignancies, displaying pivotal role cancer. homeostasis regulated levels, from absorption enterocytes to recycling macrophages storage hepatocytes. Mutations

Language: Английский

Citations

86
Iron: An Essential Element of Cancer Metabolism DOI Creative Commons
Myriam Y. Hsu,

Erica Mina,

Antonella Roetto

et al.

Cells, Journal Year: 2020, Volume and Issue: 9(12), P. 2591 - 2591

Published: Dec. 3, 2020

Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in a hostile environment characterized by nutrient deprivation, poor vascularization and immune infiltration. While reprogramming has been recognized as hallmark of cancer, the role micronutrients shaping these adaptations remains scarcely investigated. In particular, broad electron-transferring abilities iron make it versatile cofactor that is involved myriad biochemical reactions vital cellular homeostasis, including cell respiration DNA replication. cancer patients, systemic metabolism commonly altered. Moreover, deploy diverse mechanisms increase bioavailability fuel tumor growth. Although itself can readily participate redox enabling processes, its reactivity also gives rise reactive oxygen species (ROS). Hence, further rely on antioxidant withstand such stress. The present review provides an overview common alterations occurring through which promotes

Language: Английский

Citations

85
Iron deficiency, immunology, and colorectal cancer DOI
Oliver Phipps, Matthew Brookes, Hafid O. Al‐Hassi

et al.

Nutrition Reviews, Journal Year: 2020, Volume and Issue: 79(1), P. 88 - 97

Published: May 4, 2020

Excessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced intake low systemic levels are also associated with pathogenesis This is important because patients cancer often present deficiency. Iron necessary for appropriate immunological functions; hence, deficiency may hinder immunosurveillance potentially modify tumor immune microenvironment, both which assist development. supported by studies showing have inferior outcomes response therapy. Here, we provide an overview consequences suggest ensuring adequate therapy limit these outcomes.

Language: Английский

Citations

75
Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals DOI Creative Commons
Da-Young Lee, Moon-Young Song, Eun‐Hee Kim

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 743 - 743

Published: May 7, 2021

Colorectal cancer still has a high incidence and mortality rate, according to report from the American Cancer Society. prevalence in patients with inflammatory bowel disease. Oxidative stress, including reactive oxygen species (ROS) lipid peroxidation, been known cause diseases malignant disorders. In particular, nuclear factor erythroid 2-related 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well protect cells oxidative stress inflammation. Nrf2 was first found homolog of hematopoietic transcription p45 NF-E2, member Cap ‘N’ Collar family. KEAP1 as negative regulator that rapidly degrades through proteasome system. A range evidence shown consumption phytochemicals preventive or inhibitory effect on progression proliferation, depending stage colorectal cancer. Therefore, discovery regulating Nrf2/KEAP1 axis verification their efficacy have attracted scientific attention. this review, we summarize role signaling cancer, possible utility respect regulation

Language: Английский

Citations

66
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression DOI Creative Commons
Huanjie Chen,

Zhoufan Li,

Jingchao Xu

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 17

Published: Jan. 14, 2023

Follicular thyroid cancer (FTC) is a highly aggressive type of endocrine malignancy. It necessary to investigate the mechanisms tumorigenesis and therapeutic pathways in patients with FTC. Haem oxygenase-1 (HO-1) can regulate oxidative stress occurrence tumors diseases. In this study, we discovered that HO-1 was abnormally overexpressed FTC compared adjacent tissues. However, overexpression demonstrated decrease cell viability potentially activate ferroptosis signalling pathway. Ferroptosis newly identified form death currently being targeted as new treatment. Tumorigenesis significantly inhibited by curcumin. The present study shows curcumin inhibits growth increasing expression, further activating This demonstrates HO-1-ferroptosis pathway might play an important role tumorigenesis, cells affecting

Language: Английский

Citations

28
A Systematic Review of Molecular Hydrogen Therapy in Cancer Management DOI Creative Commons

Muhammad Nooraiman Zufayri Mohd Noor,

Adlin Sofea Alauddin,

Yin How Wong

et al.

Asian Pacific Journal of Cancer Prevention, Journal Year: 2023, Volume and Issue: 24(1), P. 37 - 47

Published: Jan. 1, 2023

Background: Cancer remains a challenging target to cure, with present therapeutic methods unable exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported be promising adjunctive therapy for cancer treatment, having the capability induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural This review summarises findings from various articles on mechanism, treatment outcomes, overall effectiveness of H2 management. Methods: Using Cochrane, PubMed, Google Scholar as search engines, full-text in scope study, written English within 10 years publication were selected. Results: Out 677 articles, 27 fulfilled eligibility criteria, where data was compiled into table, outlining general characteristics findings. Throughout different forms administration, study design types cancers reported, found consistent. Conclusion: From our analysis, plays role an independent well adjuvant combination therapy, resulting improvement survivability, quality life, blood parameters, tumour reduction. Although more comprehensive research is needed, given worth considering use complement current therapy.

Language: Английский

Citations

25
Heme: The Lord of the Iron Ring DOI Creative Commons
Vanessa Azevedo Voltarelli, Rodrigo Wagner Alves de Souza, Kenji Miyauchi

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1074 - 1074

Published: May 10, 2023

Heme is an iron-protoporphyrin complex with essential physiologic function for all cells, especially those in which heme a key prosthetic group of proteins such as hemoglobin, myoglobin, and cytochromes the mitochondria. However, it also known that can participate pro-oxidant pro-inflammatory responses, leading to cytotoxicity various tissues organs kidney, brain, heart, liver, immune cells. Indeed, heme, released result tissue damage, stimulate local remote inflammatory reactions. These initiate innate responses that, if left uncontrolled, compound primary injuries promote organ failure. In contrast, cadre receptors are arrayed on plasma membrane designed either import into cell, or purpose activating specific signaling pathways. Thus, free serve deleterious molecule, one traffic highly cellular teleologically important survival. Herein, we review metabolism pathways, including synthesis, degradation, scavenging. We will focus trauma diseases, traumatic brain injury, trauma-related sepsis, cancer, cardiovascular diseases where current work suggests may be most important.

Language: Английский

Citations

25
HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation DOI

Yan-Ting Lv,

Tian-Bin Liu,

Yue Li

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 399, P. 111152 - 111152

Published: July 16, 2024

Language: Английский

Citations

10
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

10