Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 8, 2023
Abstract
Aging
is
characterized
by
systemic
chronic
inflammation,
which
accompanied
cellular
senescence,
immunosenescence,
organ
dysfunction,
and
age-related
diseases.
Given
the
multidimensional
complexity
of
aging,
there
an
urgent
need
for
a
systematic
organization
inflammaging
through
dimensionality
reduction.
Factors
secreted
senescent
cells,
known
as
senescence-associated
secretory
phenotype
(SASP),
promote
inflammation
can
induce
senescence
in
normal
cells.
At
same
time,
accelerates
immune
resulting
weakened
function
inability
to
clear
cells
inflammatory
factors,
creates
vicious
cycle
senescence.
Persistently
elevated
levels
organs
such
bone
marrow,
liver,
lungs
cannot
be
eliminated
leading
damage
aging-related
Therefore,
has
been
recognized
endogenous
factor
elimination
could
potential
strategy
anti-aging.
Here
we
discuss
at
molecular,
cellular,
organ,
disease
levels,
review
current
aging
models,
implications
cutting-edge
single
cell
technologies,
well
anti-aging
strategies.
Since
preventing
alleviating
diseases
improving
overall
quality
life
are
ultimate
goals
research,
our
highlights
critical
features
mechanisms
along
with
latest
developments
future
directions
providing
theoretical
foundation
novel
practical
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Mechanisms of Ageing and Development,
Journal Year:
2023,
Volume and Issue:
211, P. 111797 - 111797
Published: March 1, 2023
Sexual
dimorphism
is
a
key
factor
to
consider
in
the
ageing
process
given
impact
that
it
has
on
life
expectancy.
The
oxidative-inflammatory
theory
of
states
result
establishment
oxidative
stress
which,
due
interplay
immune
system,
translates
into
inflammatory
stress,
and
both
processes
are
responsible
for
damage
loss
function
an
organism.
We
show
there
relevant
gender
differences
number
markers
propose
they
may
account
differential
lifespan
between
sexes,
males
display,
general,
higher
oxidation
basal
inflammation.
In
addition,
we
explain
significant
role
circulating
cell-free
DNA
as
marker
inductor
inflammation,
connecting
having
potential
become
useful
marker.
Finally,
discuss
how
changes
take
place
differentially
with
each
sex,
which
could
also
have
sex-differential
lifespan.
Further
research
including
sex
essential
variable
needed
understand
grounds
better
comprehend
itself.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(23), P. 15182 - 15182
Published: Dec. 2, 2022
During
Inflammaging,
a
dysregulation
of
the
immune
cell
functions
is
generated,
and
these
cells
acquire
senescent
phenotype
with
an
increase
in
pro-inflammatory
cytokines
ROS.
This
molecules
contributes
to
chronic
inflammation
oxidative
damage
biomolecules,
classically
observed
Inflammaging
process.
One
most
critical
damages
generated
host
DNA.
Damaged
DNA
located
out
natural
compartments,
such
as
nucleus
mitochondria,
present
cell's
cytoplasm.
localization
activates
some
sensors,
cGAS/STING
signaling
pathway,
that
induce
transcriptional
factors
involved
increasing
inflammatory
molecules.
Some
targets
this
pathway
are
SASPs.
SASPs
secreted
characteristic
inducers
ROS
production.
It
has
been
suggested
nuclear
mitochondrial
generates
activation
levels
induced
by
These
additional
damage,
causing
loop
during
Inflammaging.
However,
relationship
between
not
clarified.
review
attempt
describe
potential
connection
process,
based
on
current
literature,
contribution
knowledge
molecular
mechanisms
occur
contribute
development
considered
adaptative
process
aging.
Frontiers in Aging,
Journal Year:
2022,
Volume and Issue:
3
Published: July 22, 2022
In
this
review,
we
discuss
in
detail
the
most
relevant
proteolytic
systems
that
together
with
chaperones
contribute
to
creating
proteostasis
network
is
kept
dynamic
balance
maintain
overall
functionality
of
cellular
proteomes.
Data
accumulated
over
decades
demonstrate
effectiveness
elements
declines
age.
scenario,
failure
degrade
misfolded
or
faulty
proteins
increases
risk
protein
aggregation,
chronic
inflammation,
and
development
age-related
diseases.
This
especially
important
context
aging-related
modification
functions
immune
system.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Abstract
Oxidative
stress,
chronic
inflammation,
and
immune
senescence
are
important
pathologic
factors
in
diabetic
wound
nonhealing.
This
study
loads
taurine
(Tau)
into
cerium
dioxide
(CeO
2
)
to
develop
CeO
@Tau
nanoparticles
with
excellent
antioxidant,
anti‐inflammatory,
anti‐aging
properties.
To
enhance
the
drug
penetration
efficiency
wounds,
is
encapsulated
gelatin
methacryloyl
(GelMA)
hydrogel
prepare
@Tau@Hydrogel@Microneedle
(CTH@MN)
patch
system.
Microneedle
technology
achieves
precise
efficient
delivery
of
@Tau,
ensuring
their
deep
tissue
for
optimal
efficacy.
Rigorous
vitro
vivo
tests
have
confirmed
satisfactory
therapeutic
effect
CTH@MN
on
healing.
Mechanistically,
attenuates
oxidative
damage
inflammatory
responses
macrophages
by
inhibiting
ROS/NF‐κB
signaling
pathway.
Meanwhile,
activated
autophagy‐mediated
activity,
creating
a
favorable
microenvironment
repair.
Notably,
mouse
model,
multifunctional
significantly
promotes
healing
systematically
regulating
oxidation‐inflammation‐aging
(oxi‐inflamm‐aging)
pathological
axis.
In
conclusion,
in‐depth
exploration
system
this
provides
new
strategies
perspectives
treating
non‐healing
wounds.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 19, 2024
Abstract
Immune
function
and
redox
markers
are
used
for
estimating
the
aging
rate,
namely
biological
age
(BA).
However,
it
is
unknown
if
this
BA
its
changes
can
be
reflected
in
longevity.
Thus,
we
must
quantify
experimental
animals.
In
peritoneal
immune
cells
of
202
female
mice
(ICR/CD1)
different
ages,
10
6
parameters
were
evaluated
to
construct
two
mathematical
models
quantification
by
multiple
linear
regression.
selected
as
independent
variables
chronological
dependent,
developing
models:
Immunity
Redox
Clocks,
reaching
both
an
adjusted
R
2
80.9%
a
standard
error
6.38
8.57
weeks,
respectively.
Both
validated
group
healthy
obtaining
Pearson’s
correlation
coefficient
0.844
0.800
(
p
<
0.001)
between
BA.
Furthermore,
they
applied
adult
prematurely
mice,
which
showed
higher
than
non-prematurely
mice.
Moreover,
after
positive
negative
lifestyle
interventions,
lower
BA,
respectively,
their
age-matched
controls.
conclusion,
Clocks
allow
ImmunolAge
RedoxAge
relate
lifespan.
