The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 566 - 566

Published: April 6, 2021

As human life expectancy is rising, the incidence of age-associated diseases will also increase. Scientific evidence has revealed that healthy diets, including good fats, vitamins, minerals, or polyphenolics, could have antioxidant and anti-inflammatory activities, with antiaging effects. Recent studies demonstrated vitamin K a vital cofactor in activating several proteins, which act against age-related syndromes. Thus, can carboxylate osteocalcin (a protein capable transporting fixing calcium bone), activate matrix Gla (an inhibitor vascular calcification cardiovascular events) Gas6 (involved brain physiology cognitive decline neurodegenerative disease inhibitor). By improving insulin sensitivity, lowers diabetes risk. It exerts antiproliferative, proapoptotic, autophagic effects been associated reduced risk cancer. research shows S, another K-dependent protein, prevent cytokine storm observed COVID-19 cases. The activation S due to pneumonia-induced depletion was correlated higher thrombogenicity possibly fatal outcomes patients. Our review aimed present latest scientific about its role preventing and/or effectiveness medical treatments mature adults ˃50 years old.

Language: Английский

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Nut Consumption for Cognitive Performance: A Systematic Review

Advances in Nutrition, Journal Year: 2020, Volume and Issue: 12(3), P. 777 - 792

Published: Oct. 28, 2020

Diet is considered an important modifiable lifestyle factor capable of attenuating early cognitive changes in healthy older people. The inclusion nuts the diet has been investigated as a dietary strategy for maintenance brain health across lifespan. This review aimed to present up-to-date evidence regarding association between nut intake and performance. Four databases (Ovid MEDLINE, Scopus, Cumulative Index Nursing Allied Health Literature (CINAHL) Plus, Embase) were systematically searched from inception April 2020. Eligible articles interventional or observational studies humans aged ≥18 y that measured effects (or association) (almond, hazelnut, macadamia, pistachio, walnut, pecan, pine nut, Brazil cashew, peanut) on outcomes. Out 2374 identified searches, 22 involving 43,793 participants met criteria ultimately included this review. Memory (immediate delayed), attention, processing speed, executive function, visual-spatial ability, well risk mild impairment, outcomes investigated. Lack consistency study design, types used, resulted inconsistent regular consumption mixed protective effect cognition adults different ages. Nonetheless, we observed targeting populations with higher decline tended find more favorable outcome. Furthermore, homogeneous findings specifically addressed walnut performance: out 6 studies, including 2 randomized controlled trials, only 1 did not positive association.

Language: Английский

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Advances in Rootstock Breeding of Nut Trees: Objectives and Strategies

Plants, Journal Year: 2021, Volume and Issue: 10(11), P. 2234 - 2234

Published: Oct. 20, 2021

The production and consumption of nuts are increasing in the world due to strong economic returns nutritional value their products. With role importance given (i.e., walnuts, hazelnut, pistachio, pecan, almond) a balanced healthy diet benefits human health, breeding species has also been stepped up. Most recent fruit programs have focused on scion genetic improvement. However, use locally adapted grafted rootstocks enhanced productivity quality tree crops. Grafting is an ancient horticultural practice used nut crops manipulate phenotype overcome biotic abiotic stresses. There complex rootstock objectives physiological molecular aspects rootstock–scion interactions In this review, we provide overview these, considering mechanisms involved nutrient water uptake, regulation phytohormones, influences processes, including long-distance gene silencing trans-grafting. Understanding resulting from × environmental will contribute developing new with resilience face climate change, but multitude diseases pests.

Language: Английский

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Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1412 - 1412

Published: July 21, 2022

Biomarkers of metabolic syndrome and inflammation are pathophysiological predictors factors senescence age-related diseases. Recent evidence showed that particular diet components, such as walnuts rich in antioxidant bioactive compounds with a balanced lipid profile, could have positive outcomes on human health. A systematic search PubMed, EMBASE, Cochrane Library, Scopus, ClinicalTrials.gov databases was performed to retrieve randomized controlled trials published from the beginning each database through November 2021, reporting walnut consumption over 22 inflammatory markers middle-aged older adults. The strategy rendered 17 studies final selection, including 11 crossover 6 parallel trials. study revealed walnut-enriched diets had statistically significant decreasing effects for triglyceride, total cholesterol, LDL cholesterol concentrations some presented no consequences anthropometric glycemic parameters. Although further better-designed ones needed strengthen these findings, results emphasize benefits dietary plans this age group.

Language: Английский

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Phytochemicals and Biological Activities of Walnut Septum: A Systematic Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 604 - 604

Published: March 1, 2023

In the last few decades, scientific evidence has stressed importance of plants in prevention and/or supportive treatment a plethora diseases, many them chronic, age-associated disorders. Juglans regia L. is traditional plant that been integrated into medicine since ancient times. Due to presence biologically active compounds, walnut was used various maladies. Recently, investigations have focused on by-products and waste products, with research their valuable constituents properties. Among these secondary septum analyzed several studies, its phytochemical profile described, some biological activities examined. However, compared other by-products, no comprehensive review gather all pertinent knowledge found literature. Therefore, aim this study critically assess information furnished by peer-reviewed articles regarding chemical composition related activities, including antioxidant anti-inflammatory effects, antimicrobial properties, antidiabetic anti-tumor anti-aging potential. conclusion, as preclinical studies showed metabolites were responsible for wide range preventive therapeutic uses, further should confirm beneficial outcomes clinical trials.

Language: Английский

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Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Oct. 22, 2020

Compilating the most relevant studies of psoralidin, a coumarin from seeds Cullen corylifolium (L.) Medik. (syn. Psoralea corylifolia L.), has recently confirmed this compound display interesting pharmacological properties. Last years, interest in had been changed and take it up due to its widespread beneficial for estrogen-related diseases as chemopreventive agent. A growing number preclinical evidence indicate that psoralidin anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral antidepressant-like effects. Here, we provide comprehensive critical review on bioavailability, activities with underlying molecular mechanisms cell signaling pathways. In light these actions human health paper gathers complete information pharmacotherapeutic effects opens new natural therapeutic perspectives chronic diseases.

Language: Английский

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Antioxidant Effects of Walnut (Juglans regia L.) Kernel and Walnut Septum Extract in a D-Galactose-Induced Aging Model and in Naturally Aged Rats

Antioxidants, Journal Year: 2020, Volume and Issue: 9(5), P. 424 - 424

Published: May 14, 2020

Antioxidant dietary intervention is considered a potential strategy in delaying age-related dysfunctions. In this study of 56 days, we assessed the antioxidant effects walnut kernel (WK) and septum extract (WSE) D-galactose (D-gal)-induced aging model naturally aged rat model. Young Wistar rats, treated with D-gal (1200 mg/week), old rats received daily WK or WSE added to feed. After 8 weeks, blood, liver, brain samples were collected hematological, biochemical, oxidative stress biomarkers, histological, immunohistochemical analyses performed. Moreover, acetylcholinesterase activity was investigated homogenates. The outcomes demonstrated significant improvement cellular and/or decrease reactive oxygen species, advanced glycation end products, nitric oxide, malondialdehyde, increase glutathione after intake both models. Additionally, showed hypoglycemic effect, lowered activity. Both diets could protect neurons against induced senescence reverse pathological conditions physiological brain. Thus, supplementation can maintain liver health reduce risk diseases, as well onset processes.

Language: Английский

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Nuts and Cardio-Metabolic Disease: A Review of Meta-Analyses

Nutrients, Journal Year: 2018, Volume and Issue: 10(12), P. 1935 - 1935

Published: Dec. 6, 2018

Objectives: Accumulating epidemiological and intervention evidence suggest that nut consumption is associated with reduced incidence of some cardiometabolic diseases. However, to date no review meta-analyses studies has evaluated the effects on disease. Design/Results: Electronic searches for were undertaken in PubMed®/MEDLINE®. Meta-analyses prospective show appears be all-cause mortality by 19–20% (n = 6), cardiovascular disease (CVD) (19%; n 3) (25%; 3), coronary heart (CHD) (20–34%; 2) (27–30%; stroke (10–11%; 7) (18%; 2). No association between risk type 2 diabetes mellitus (T2DM) was observed studies, whereas a decrease fasting blood glucose ranging from 0.08 0.15 mmol/L 3 studies. In interventions, also had favorable total cholesterol (0.021 0.28 reduction 8 interventions) low-density lipoprotein (0.017 0.26 endothelial function (0.79 1.03% increase flow-mediated dilation 4 interventions). Nut did not significantly affect body weight. effect inflammatory markers The pressure inconsistent. A higher lower hypertension while improve Conclusions: appeared CVD CHD mortality. There T2DM although decreased nuts (LDL-C).

Language: Английский

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Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects

Molecules, Journal Year: 2020, Volume and Issue: 25(9), P. 2187 - 2187

Published: May 7, 2020

Walnut (

Language: Английский

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Enhanced Recovery of Antioxidant Compounds from Hazelnut (Corylus avellana L.) Involucre Based on Extraction Optimization: Phytochemical Profile and Biological Activities

Antioxidants, Journal Year: 2019, Volume and Issue: 8(10), P. 460 - 460

Published: Oct. 8, 2019

Tree nut by-products could contain a wide range of phytochemicals, natural antioxidants, which might be used as source for dietary supplements. The aim the present study was to evaluate phenolic and sterolic composition, well antioxidant other biological activities, hazelnut involucre (HI) extracts. Experimental designs were developed in order select optimum extraction conditions (solvent, temperature, time) using turbo-extraction by Ultra-Turrax obtaining extracts rich bioactive compounds. Qualitative quantitative analyses performed LC-MS LC-MS/MS they revealed important amounts individual polyphenols phytosterols, molecules with potential. richest polyphenolic HI extract highest activity TEAC assay further evaluated vitro tests (DPPH, FRAP) enzyme inhibitory assays. Additionally, cytotoxic effects this on two cancerous cell lines normal cells tested. This is first analyze composition both hydrophilic lipophilic compounds Our findings reveal that plant by-product presents strong justifying research, it considered an inexpensive antioxidants food, pharmaceutical, or cosmetic industry.

Language: Английский

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