Molecules,
Journal Year:
2020,
Volume and Issue:
25(21), P. 5186 - 5186
Published: Nov. 7, 2020
Cannabidiol
(CBD)
is
a
non-psychoactive
phytocannabinoid
known
for
its
beneficial
effects
including
antioxidant
and
anti-inflammatory
properties.
Moreover,
CBD
compound
with
antidepressant,
anxiolytic,
anticonvulsant
antipsychotic
effects.
Thanks
to
all
these
properties,
the
interest
of
scientific
community
it
has
grown.
Indeed,
great
candidate
management
neurological
diseases.
The
purpose
our
review
summarize
in
vitro
vivo
studies
published
last
15
years
that
describe
biochemical
molecular
mechanisms
underlying
therapeutic
application
exerts
neuroprotective
through
three
G
protein
coupled-receptors
(adenosine
receptor
subtype
2A,
serotonin
1A
protein-coupled
55),
one
ligand-gated
ion
channel
(transient
potential
vanilloid
channel-1)
nuclear
factor
(peroxisome
proliferator-activated
γ).
therapeutical
properties
are
also
due
GABAergic
modulation.
In
conclusion,
CBD,
multi-target
mechanisms,
represents
valid
tool
epilepsy,
Alzheimer's
disease,
multiple
sclerosis
Parkinson's
disease.
Fitoterapia,
Journal Year:
2021,
Volume and Issue:
152, P. 104915 - 104915
Published: May 6, 2021
Positive
effect
of
some
cannabinoids
in
the
treatment
and
prophylaxis
a
wide
variety
oxidation-associated
diseases
growing
popularity
supplements
containing
cannabinoids,
mainly
cannabinoid
oils
(e.g.
CBD
oil,
CBG
oil),
self-medication
humans
cause
interest
antioxidant
properties
these
compounds,
especially
those
not
showing
psychotropic
effects.
Herein,
we
report
activity
cannabigerol
(CBG),
cannabidiol
(CBD),
Δ9-tetrahydrocannabinol
(Δ9-THC),
cannabinol
(CBN),
cannabigerolic
acid
(CBGA),
cannabinolic
(CBDA)
Δ9-tetrahydrocannabinolic
(Δ9-THCA)
estimated
by
spectrophotometric
methods:
ABTS,
DPPH,
ORAC,
beta-carotene
CUPRAC
FRAP.
The
presented
data
prove
that
all
examined
exhibit
manifested
their
ability
to
scavenge
free
radicals,
prevent
oxidation
process
reduce
metal
ions.
Although
intensity
activities
is
same
for
individual
it
comparable
them
with
E
vitamin.
As
results
from
research,
significance
two
types
electron
sources
presenting
phenolic
groups
double
bonds
transferring
electrons,
depends
on
type
electron-accepting
species
-
radicals/metal
Toxins,
Journal Year:
2021,
Volume and Issue:
13(2), P. 117 - 117
Published: Feb. 5, 2021
For
thousands
of
years,
Cannabis
sativa
has
been
utilized
as
a
medicine
and
for
recreational
spiritual
purposes.
Phytocannabinoids
are
family
compounds
that
found
in
the
cannabis
plant,
which
is
known
its
psychotogenic
euphoric
effects;
main
psychotropic
constituent
Δ9-tetrahydrocannabinol
(Δ9-THC).
The
pharmacological
effects
cannabinoids
result
interactions
between
those
cannabinoid
receptors,
CB1
CB2,
located
many
parts
human
body.
used
therapeutic
agent
treating
pain
emesis.
Some
clinically
applied
chronic
pain,
particularly
cancer
multiple
sclerosis-associated
appetite
stimulation
anti-emesis
HIV/AIDS
patients,
spasticity
treatment
sclerosis
epilepsy
patients.
Medical
varies
from
chemical
content
THC
cannabidiol
(CBD),
modes
administration,
safety.
Despite
cannabis,
exposure
to
high
concentrations
THC,
compound
responsible
most
intoxicating
experienced
by
users,
could
lead
psychological
events
adverse
affect
almost
all
body
systems,
such
neurological
(dizziness,
drowsiness,
seizures,
coma,
others),
ophthalmological
(mydriasis
conjunctival
hyperemia),
cardiovascular
(tachycardia
arterial
hypertension),
gastrointestinal
(nausea,
vomiting,
thirst),
mainly
associated
with
use.
toxicity
children
more
concerning
can
cause
serious
acute
symptoms
(stupor),
lethargy,
even
coma.
More
countries
legalizing
commercial
production
sale
medicinal
use,
some
use
well.
Liberalization
laws
led
increased
incidence
toxicity,
hyperemesis
syndrome,
lung
disease
disease,
reduced
fertility,
tolerance,
dependence
prolonged
This
review
focuses
on
potential
cannabinoids,
well
toxic
various
systems.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(2), P. 778 - 778
Published: Jan. 14, 2021
Cannabis
sativa
L.
turned
out
to
be
a
valuable
source
of
chemical
compounds
various
structures,
showing
pharmacological
activity.
The
most
important
groups
include
phytocannabinoids
and
terpenes.
activity
(in
epilepsy,
sclerosis
multiplex
(SM),
vomiting
nausea,
pain,
appetite
loss,
inflammatory
bowel
diseases
(IBDs),
Parkinson’s
disease,
Tourette’s
syndrome,
schizophrenia,
glaucoma,
coronavirus
disease
2019
(COVID-19)),
which
has
been
proven
so
far,
results
from
the
affinity
these
predominantly
for
receptors
endocannabinoid
system
(the
cannabinoid
receptor
type
1
(CB1),
two
(CB2),
G
protein-coupled
55
(GPR55))
but,
also,
peroxisome
proliferator-activated
(PPAR),
glycine
receptors,
serotonin
(5-HT),
transient
potential
channels
(TRP),
GPR,
opioid
receptors.
synergism
action
phytochemicals
present
in
sp.
raw
material
is
also
expressed
their
increased
bioavailability
penetration
through
blood–brain
barrier.
This
review
provides
an
overview
phytochemistry
pharmacology
extracts
context
current
knowledge
about
synergistic
actions
implications
clinical
use
treatment
selected
diseases.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(21), P. 5186 - 5186
Published: Nov. 7, 2020
Cannabidiol
(CBD)
is
a
non-psychoactive
phytocannabinoid
known
for
its
beneficial
effects
including
antioxidant
and
anti-inflammatory
properties.
Moreover,
CBD
compound
with
antidepressant,
anxiolytic,
anticonvulsant
antipsychotic
effects.
Thanks
to
all
these
properties,
the
interest
of
scientific
community
it
has
grown.
Indeed,
great
candidate
management
neurological
diseases.
The
purpose
our
review
summarize
in
vitro
vivo
studies
published
last
15
years
that
describe
biochemical
molecular
mechanisms
underlying
therapeutic
application
exerts
neuroprotective
through
three
G
protein
coupled-receptors
(adenosine
receptor
subtype
2A,
serotonin
1A
protein-coupled
55),
one
ligand-gated
ion
channel
(transient
potential
vanilloid
channel-1)
nuclear
factor
(peroxisome
proliferator-activated
γ).
therapeutical
properties
are
also
due
GABAergic
modulation.
In
conclusion,
CBD,
multi-target
mechanisms,
represents
valid
tool
epilepsy,
Alzheimer's
disease,
multiple
sclerosis
Parkinson's
disease.
