Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

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Moringa oleifera: a valuable insight into recent advances in medicinal uses and pharmacological activities

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 103(15), P. 7343 - 7361

Published: Aug. 3, 2023

Moringa oleifera is an important medicinal plant in several countries; for example, Nigeria, the USA, Turkey, Germany, Greece, and Ukraine. The abundant bioactive nutritional properties of this make it useful many diverse areas life, including health, cosmetic, agricultural, food industries to mention but a few. Research has found that presence proteins, carbohydrates, lipids, vitamins, minerals, flavonoids, phenols, alkaloids, fatty acids, saponins, essential oils, folate, aromatic hydrocarbons, sterols, glucosinolates, glycosides, among others, characterize moringa nutrient profile and, as result, give rise its remedial effects on ailments such wounds, stomach duodenal ulcers, allergies, obesity, diabetes, inflammation, asthma, so on. It aim review provide insight into pharmacological remedies attributed moringa, stating both past recent discoveries. This article also takes look botanical features, compounds, antinutrients, applications, bacterial fermentation products, biosafety, industrial other uses moringa. Finally, with belief knowledge progressive, we acknowledge there are things yet undiscovered about wonder will be value medicine general life; therefore recommend research work continues plant. © 2023 Society Chemical Industry.

Language: Английский

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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

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Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Jan. 1, 2025

Language: Английский

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The gut microbiota–brain axis in neurological disorders

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

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Overview of anti-inflammatory diets and their promising effects on non-communicable diseases

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: 132(7), P. 898 - 918

Published: Oct. 14, 2024

Abstract An anti-inflammatory diet is characterised by incorporating foods with potential properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red processed meat, refined carbohydrates saturated fats are limited. This article explores the effects of an on non-communicable diseases (NCD), concentrating underlying mechanisms that connect systemic chronic inflammation, dietary choices disease outcomes. Chronic inflammation a pivotal contributor to initiation progression NCD. review provides overview intricate pathways through which influences pathogenesis conditions obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer cognitive disorders. Through comprehensive synthesis existing research, we aim identify some bioactive compounds present in deemed anti-inflammatory, explore their capacity modulate inflammatory and, consequently, prevent or manage The findings demonstrated herein contribute understanding interplay between nutrition, paving way for future recommendations research regarding preventive therapeutic strategies.

Language: Английский

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Beyond the Surface: Nutritional Interventions Integrated with Diagnostic Imaging Tools to Target and Preserve Cartilage Integrity: A Narrative Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 570 - 570

Published: Feb. 24, 2025

This narrative review provides an overview of the various diagnostic tools used to assess cartilage health, with a focus on early detection, nutrition intervention, and management osteoarthritis. Early detection damage is crucial for effective patient management. Traditional like radiography conventional magnetic resonance imaging (MRI) sequences are more suited detecting late-stage structural changes. paper highlights advanced techniques, including sodium MRI, T2 mapping, T1ρ imaging, delayed gadolinium-enhanced MRI cartilage, which provide valuable biochemical information about composition, particularly glycosaminoglycan content its potential links nutrition-related factors influencing health. Cartilage degradation often linked inflammation measurable via markers CRP IL-6 which, although not specific breakdown, offer insights into affecting cartilage. In addition markers, such as collagen breakdown products aggrecan fragments, reflect metabolic changes in discussed. Emerging optical coherence tomography hybrid positron emission tomography–magnetic (PET-MRI) also explored, offering high-resolution combined insights, respectively. Finally, wearable technology biosensors real-time monitoring osteoarthritis progression, well role artificial intelligence enhancing accuracy through pattern recognition data addressed. While these hold great osteoarthritis, challenges remain clinical translation, validation larger populations integration existing workflows personalized treatment strategies cartilage-related diseases.

Language: Английский

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Nutritional and dietary clinical trials for Parkinson's disease: a narrative review

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

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Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus: Complex Interactions and Clinical Implications

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1809 - 1809

Published: March 7, 2025

Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic conditions, frequently coexisting due to their shared pathophysiological mechanisms risk factors. Epidemiological studies estimate that up 30% of COPD patients have comorbid T2DM, contributing worsened progression, more hospitalizations, higher mortality rates. Systemic inflammation in contributes insulin resistance by increasing pro-inflammatory cytokines (TNF-α, IL-6, CRP), which impair glucose metabolism beta-cell function. Conversely, hyperglycemia T2DM exacerbates oxidative stress, leading endothelial dysfunction, reduced lung function, impaired repair mechanisms. A comprehensive narrative review was conducted evaluate the interplay between examining mechanisms, clinical consequences, management strategies. The co-occurrence accelerates development, elevates hospitalization rates, deteriorates overall prognosis. Pharmacological interactions complicate illness treatment, requiring a multidisciplinary therapy strategy. Recent data underscore need integrate palliative care, facilitate decision-making, provide psychological support enhance patient outcomes. Efficient COPD-T2DM comorbidity necessitates customized, interdisciplinary strategy targets both respiratory metabolic health. Preliminary prognostic dialogues, holistic lifestyle modifications can improve quality life results.

Language: Английский

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Exploring Plant-Based Nutrition for Patients with Substance Use Disorders: A Scoping Review of Dietary Intake and Potential Applications

Substance Use &amp Addiction Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Background: Substance use disorders (SUDs) represent a significant global public health challenge, with affected individuals often exhibiting poor dietary habits, nutritional deficiencies, and compromised mental physical health. This scoping review evaluates existing literature on intake in SUDs, focusing the potential benefits of plant-based interventions for improving status supporting recovery. Methods: A was conducted following PRISMA guidelines. Four databases were searched using PICO-based terms, targeting studies assessing patients SUD, particularly interventions. Inclusion criteria reporting macro- micronutrient among while lacking direct data excluded. Study quality appraised STROBE checklist. Results: The search yielded 1142 articles, 6 meeting inclusion (4 from United States 2 Iran). Patients SUD exhibited deficiencies iron (−16.8%, P = .04), folate (−15.0%, vitamins E A, alongside diets high simple carbohydrates unhealthy processed foods. Plant-based associated improved Healthy Eating Index scores ( < .001), increased resilience (+31%, .031), enhanced self-esteem .043). High energy low multivitamin reported methadone-treated patients, emphasizing need to address nutrient gaps support Conclusion: may offer promising strategy improve outcomes SUD. However, are limited, small sample sizes variability assessments. Future research, including randomized controlled trials, is needed establish efficacy feasibility integrating nutrition into treatment programs. Addressing barriers such as socioeconomic challenges food access also crucial implementing effective

Language: Английский

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