Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 889 - 889
Published: March 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract
Several
efforts
have
been
extensively
accomplished
for
the
amelioration
of
cancer
treatments
using
different
types
new
drugs
and
less
invasives
therapies
in
comparison
with
traditional
therapeutic
modalities,
which
are
widely
associated
numerous
drawbacks,
such
as
drug
resistance,
non-selectivity
high
costs,
restraining
their
clinical
response.
The
application
natural
compounds
prevention
treatment
cells
has
attracted
significant
attention
from
pharmaceuticals
scientific
communities
over
past
decades.
Although
use
nanotechnology
therapy
is
still
preliminary
stages,
nanotherapeutics
demonstrated
to
decrease
various
limitations
related
compounds,
physical/chemical
instability,
poor
aqueous
solubility,
low
bioavailability.
Despite
emerged
a
promise
improve
bioavailability
there
limited
trials
performed
challenges
required
pre-clinical
trials,
production
at
an
industrial
level,
assurance
long-term
stability,
physiological
barriers
safety
regulatory
issues.
This
review
highlights
most
recent
advances
nanocarriers
secreted
plants,
bacteria,
fungi,
marine
organisms,
well
role
on
cell
signaling
pathways
anticancer
treatments.
Additionally,
status
main
regarding
loaded
applications
were
also
discussed.
Graphical
abstract
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(1), P. 126 - 126
Published: Jan. 18, 2024
Resveratrol
is
a
polyphenolic
compound
that
has
gained
considerable
attention
in
the
past
decade
due
to
its
multifaceted
therapeutic
potential,
including
anti-inflammatory
and
anticancer
properties.
However,
efficacy
impeded
by
low
water
solubility,
dose-limiting
toxicity,
bioavailability,
rapid
hepatic
metabolism.
To
overcome
these
hurdles,
various
nanoparticles
such
as
organic
inorganic
nanoparticles,
liposomes,
polymeric
dendrimers,
solid
lipid
gold
zinc
oxide
zeolitic
imidazolate
frameworks,
carbon
nanotubes,
bioactive
glass
mesoporous
were
employed
deliver
resveratrol,
enhancing
against
types
of
cancer.
Resveratrol-loaded
nanoparticle
or
resveratrol-conjugated
administration
exhibits
excellent
potency
compared
free
resveratrol.
This
review
highlights
latest
developments
nanoparticle-based
delivery
systems
for
focusing
on
potential
limitations
associated
with
compound’s
bioavailability
effectiveness.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 879 - 879
Published: March 8, 2023
Despite
recent
advances,
cancer
remains
the
primary
killer
on
a
global
scale.
Numerous
forms
of
research
have
been
conducted
to
discover
novel
and
efficient
anticancer
medications.
The
complexity
breast
is
major
challenge
which
coupled
with
patient-to-patient
variations
heterogeneity
between
cells
within
tumor.
Revolutionary
drug
delivery
expected
provide
solution
that
challenge.
Chitosan
nanoparticles
(CSNPs)
prospects
as
revolutionary
system
capable
enhancing
activity
reducing
negative
impacts
normal
cells.
use
smart
systems
(SDDs)
delivering
materials
improve
bioactivity
NPs
understand
intricacies
has
garnered
significant
interest.
There
are
many
reviews
about
CSNPs
present
various
points
view,
but
they
not
yet
described
series
in
therapy
from
cell
uptake
death.
With
this
description,
we
will
more
complete
picture
for
designing
preparations
SDDs.
This
review
describes
SDDSs,
targeting
stimulus
response
using
their
mechanism.
Multimodal
chitosan
SDDs
medication
therapeutic
results.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
278, P. 134977 - 134977
Published: Aug. 24, 2024
Antibiotic
resistance
(ABR)
poses
a
universal
concern
owing
to
the
widespread
use
of
antibiotics
in
various
sectors.
Nanotechnology
emerges
as
promising
solution
combat
ABR,
offering
targeted
drug
delivery,
enhanced
bioavailability,
reduced
toxicity,
and
stability.
This
comprehensive
review
explores
concepts
antibiotic
resistance,
its
mechanisms,
multifaceted
approaches
ABR.
The
provides
an
in-depth
exploration
polymeric
nanoparticles
advanced
delivery
systems,
focusing
on
strategies
for
targeting
microbial
infections
contributing
fight
against
Nanoparticles
revolutionize
antimicrobial
approaches,
emphasizing
passive
active
targeting.
role
molecules,
including
small
peptides,
proteins,
carbohydrates,
stimuli-responsive
is
being
explored
recent
research
works.
complex
comprehension
mechanisms
ABR
strategic
nanotechnology
present
avenue
advancing
tactics,
ensuring
treatment
efficacy,
minimizing
toxic
effects,
mitigating
development
Polymeric
nanoparticles,
derived
from
natural
or
synthetic
polymers,
are
crucial
overcoming
Natural
polymers
like
chitosan
alginate
exhibit
inherent
antibacterial
properties,
while
such
polylactic
acid
(PLA),
polyethylene
glycol
(PEG),
polycaprolactone
(PCL)
can
be
engineered
specific
effects.
study
valuable
source
information
researchers,
healthcare
professionals,
policymakers
engaged
urgent
quest
overcome
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 670 - 670
Published: May 16, 2024
In
recent
years,
biopolymer-based
nano-drug
delivery
systems
with
antioxidative
properties
have
gained
significant
attention
in
the
field
of
pharmaceutical
research.
These
offer
promising
strategies
for
targeted
and
controlled
drug
while
also
providing
antioxidant
effects
that
can
mitigate
oxidative
stress-related
diseases.
Generally,
healthcare
landscape
is
constantly
evolving,
necessitating
continual
development
innovative
therapeutic
approaches
(DDSs).
DDSs
play
a
pivotal
role
enhancing
treatment
efficacy,
minimizing
adverse
effects,
optimizing
patient
compliance.
Among
these,
nanotechnology-driven
garnered
due
to
their
unique
properties,
such
as
improved
solubility,
release,
delivery.
Nanomaterials,
including
nanoparticles,
nanocapsules,
nanotubes,
etc.,
versatile
platforms
tissue
engineering
applications.
Additionally,
hold
immense
promise,
leveraging
natural
or
synthetic
biopolymers
encapsulate
drugs
enable
release.
numerous
advantages,
biocompatibility,
biodegradability,
low
immunogenicity.
The
utilization
polysaccharides,
polynucleotides,
proteins,
polyesters
biopolymer
matrices
further
enhances
versatility
applicability
DDSs.
Moreover,
substances
emerged
key
players
combating
diseases,
offering
protection
against
cellular
damage
chronic
illnesses.
nanoformulations
represents
burgeoning
research
area,
substantial
increase
publications
years.
This
review
provides
comprehensive
overview
developments
within
this
area
over
past
five
It
discusses
various
materials,
fabrication
techniques,
stabilizers,
factors
influencing
degradation,
it
highlights
emerging
trends,
challenges,
prospects
rapidly
evolving
field.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
100, P. 106007 - 106007
Published: Aug. 5, 2024
Globally,
cancer
is
regarded
as
a
severe
health
issue.
Among
these
breast
(BC),
the
second
most
common
kind
in
women
after
skin
cancer.
According
to
statistical
data
from
NIH
Cancer
Institute,
expected
number
of
cases
was
around
3
lakh
people,
with
7.1
%
fatality
rate.
The
rise
multidrug
resistance
(MDR)
British
Columbia
issue
it
lowers
effectiveness
existing
treatments.
Traditional
MDR
treatment
approaches
BC
have
drawbacks,
including
toxicity,
high
cost,
early
discharge,
restricted
drug
load
before
target,
and
poor
effectiveness.
Preventing
has
depended
heavily
on
developing
innovative
therapy
delivery
methods
utilizing
nanomedicine
new
diagnosing
treating
BC.
This
review
discusses
its
pathophysiology
relation
tumor
kinetics.
It
focuses
latest
therapeutic
over
traditional
like
Surgery,
Chemotherapy,
Nanomedicine,
Phototherapy,
Immunotherapy,
Gene
therapy.
also
describes
diagnostic
techniques
using
MRI/PET,
Mammography,
Microwave
Sensing,
In-silico
methods,
Molecular
techniques,
AI-machine
learning-based
tools.
discussed
limitations
nanoparticles
article
aims
identify
efficient
ways
diagnose
treat
prevent
recurrence.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1376 - 1376
Published: Feb. 6, 2025
Cancer
is
a
multifaceted
disease
characterised
by
uncontrolled
cellular
proliferation
and
metastasis,
resulting
in
significant
global
mortality.
Current
therapeutic
strategies,
including
surgery,
chemotherapy,
radiation
therapy,
face
challenges
such
as
systemic
toxicity
tumour
resistance.
Recent
advancements
have
shifted
towards
targeted
therapies
that
act
selectively
on
molecular
structures
within
cancer
cells,
reducing
off-target
effects.
Mitochondria
emerged
pivotal
targets
this
approach,
given
their
roles
metabolic
reprogramming,
retrograde
signalling,
oxidative
stress,
all
of
which
drive
the
malignant
phenotype.
Targeting
mitochondria
offers
promising
strategy
to
address
these
mechanisms
at
origin.
Synthetic
derivatives
natural
compounds
hold
particular
promise
mitochondrial-targeted
therapies.
Innovations
drug
design,
use
conjugates
nanotechnology,
focus
optimizing
for
mitochondrial
specificity.
Such
enhance
efficacy
while
minimizing
toxicity,
presenting
step
forward
modern
anticancer
strategies.
Gels,
Journal Year:
2023,
Volume and Issue:
9(3), P. 239 - 239
Published: March 18, 2023
The
biomolecule
deoxyribonucleic
acid
(DNA),
which
acts
as
the
carrier
of
genetic
information,
is
also
regarded
a
block
copolymer
for
construction
biomaterials.
DNA
hydrogels,
composed
three-dimensional
networks
chains,
have
received
considerable
attention
promising
biomaterial
due
to
their
good
biocompatibility
and
biodegradability.
hydrogels
with
specific
functions
can
be
prepared
via
assembly
various
functional
sequences
containing
modules.
In
recent
years,
been
widely
used
drug
delivery,
particularly
in
cancer
therapy.
Benefiting
from
sequence
programmability
molecular
recognition
ability
molecules,
using
modules
achieve
efficient
loading
anti-cancer
drugs
integration
therapeutic
effects,
thus
achieving
targeted
delivery
controlled
release,
are
conducive
this
review,
we
summarized
strategies
preparation
on
basis
branched
modules,
hybrid
chain
reaction
(HCR)-synthesized
rolling
circle
amplification
(RCA)-produced
respectively.
application
carriers
therapy
has
discussed.
Finally,
future
development
directions
prospected.
Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
7(2), P. 202 - 209
Published: Jan. 1, 2023
Head
and
neck
cancer
is
affecting
a
large
sort
of
population.Many
treatments
are
available
on
regular
base,
but
they
have
their
limitations.Diagnosis
in
the
early
stage
essential
to
cope
with
disease
which
limitation
majority
present
diagnostic
tools.Many
them
invasive
methods
that
lead
patient
discomfort.Interventional
nanothernostics
an
emerging
field
management
Neck
cancer.It
facilitates
both
therapeutic
approaches.It
also
helps
overall
disease.This
method
allows
accurate
detection
improvises
chances
recovery.Additionally,
it
makes
sure
medicine
delivered
specifically
increase
clinical
outcomes
reduce
side
effects.The
use
radiation
addition
supplied
can
produce
synergistic
effect.It
contains
several
nanoparticles,
including
silicon
gold
nanoparticles.This
review
paper
focuses
shortcomings
existing
techniques
how
nanotheranostics
fills
void.
