Engineering Hydrogel-Based Composites for Photoluminescent Biomaterials
Engineering materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 231 - 257
Published: Jan. 1, 2025
Language: Английский
Hybrid Organic–Inorganic Biomaterials as Drug Delivery Systems: A Molecular Dynamics Study of Quercetin Adsorption on Amorphous Silica Surfaces
Coatings,
Journal Year:
2024,
Volume and Issue:
14(2), P. 234 - 234
Published: Feb. 17, 2024
Many
important
drugs
in
pharmaceutical
applications
are
poorly
soluble.
Solubilization,
which
is
diffusion
through
biological
barriers,
and
the
control
of
local
administration
crucial
steps
for
bioavailability
to
avoid
cytotoxic
effects.
Hybrid
organic/inorganic
biomaterials
can
incorporate
situ
release
after
implantation.
Molecular
Mechanics
(MM)
Dynamics
(MD)
simulations
useful
tools
investigating
intermolecular
interactions
between
drug
biomaterial
surfaces
at
atomistic
level
these
applications.
This
work
studies
quercetin,
a
flavonoid
its
anti-inflammatory,
antioxidant,
anticancer
properties,
amorphous
SiO2
surface
using
simulation
protocol
proposed
previous
related
ketoprofen
drugs.
After
adsorption
on
silica
surface,
process
quercetin
molecules
two
different
concentrations
near
hydrated
then
dried
investigated.
Interestingly,
theoretical
results
compared
with
experimental
data
obtained
via
Fourier
Transform
Infrared
Spectroscopy
(FT–IR)
spectra
homogenously
entrapped
matrix
Sol–Gel
method.
Favorable
H–
bonds
some
π–π
among
new
generation
biocompatible
materials
capable
incorporating
anti-inflammatory
agents
into
human
body.
Language: Английский
The pivotal role of the polyethylene glycol amount as compatibilizing on the morphological features of silica-based blends
Journal of Thermoplastic Composite Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 16, 2024
Silica-based
hybrid
blends
at
different
molecular
or
nanometer
scale
have
gained
a
lot
of
interests
from
the
technological
point
view.
In
particular,
several
inorganic-organic
hybrids
find
application
in
biomedical
field.
this
context,
inorganic
SiO
2
and
made
up
polyethylene
glycol
(PEG)
been
synthesised
via
sol-gel
route
characterised
morphological
(throught
Atomic
Force
Microscopy
-
AFM)
spectroscopic
view
to
shed
light
on
their
features
as
possible
biomaterials.
AFM
investigation
allowed
for
an
effective
quantitative
evaluation
surface
roughness
bioactive
sol-gel-based
materials.
The
results
revealed
increase
material
porosity
function
PEG
amount
systems,
thus
highlighting
pivotal
role
compatibilizing
silica-based
blends.
co-presence
both
organic
phases
was
confirmed
by
Fourier-transform
infrared
spectroscopy
(FT-IR).
Moreover,
influence
also
investigated
analysing
deconvoluted
FT-IR
spectra
range
1600-750
cm
−1
.
Language: Английский
Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5268 - 5268
Published: June 18, 2024
The
sol-gel
technique
stands
out
as
a
valuable
method
for
synthesizing
biomaterials
and
encapsulating
bioactive
molecules,
offering
potential
controlled
drug
release
tissue
regeneration
in
biomedical
contexts.
This
study
focused
on
silica
(Si)-based
hybrid
containing
5%
quercetin
(Q5)
using
two
different
approaches:
one
involving
nitric
acid
catalyst
(SiQ5-HNO3)
the
other
being
acid-free
(SiQ5).
Structural
characterization
Fourier
transform
infrared
(FTIR)
UV-vis
spectroscopy
revealed
oxidation
processes
compromising
structural
integrity
of
both
systems.
However,
it
was
observed
that
these
led
to
formation
oxidized
derivatives
with
distinct
structures.
Additionally,
bioactivity
kinetics
from
matrices
were
evaluated,
showing
systems
capable
forming
hydroxyapatite,
indicating
excellent
bioactivity.
Furthermore,
SiQ5
exhibited
higher
percentage
encapsulated
at
pH
7.4,
representing
physiological
environment,
compared
SiQ5-HNO3,
drastic
reduction
5.0
(cancer
environment).
Antibacterial
efficacy
assessment
Kirby–Bauer
test
highlighted
greater
antibacterial
activity
SiQ5-HNO3
system
against
all
tested
strains.
Overall,
this
research
aims
advance
development
more
effective
various
applications,
particularly
engineering
infection
control.
Language: Английский
Silica 3D printed scaffolds as pH stimuli-responsive drug release platform
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101187 - 101187
Published: Aug. 9, 2024
Silica-based
scaffolds
are
promising
in
Tissue
Engineering
by
enabling
personalized
scaffolds,
boosting
exceptional
bioactivity
and
osteogenic
characteristics.
Moreover,
silica
materials
highly
tunable,
allowing
for
controlled
drug
release
to
enhance
tissue
regeneration.
In
this
study,
we
developed
a
3D
printable
material
with
mesoporosity,
achieved
through
the
sol-gel
reaction
of
tetraethyl
orthosilicate
(TEOS)
at
mild
temperatures
addition
different
calcium
concentrations.
The
resultant
inks
exhibited
high
printability
shape
fidelity,
while
maintaining
biocompatibility.
Notably,
increased
mesopore
size
enhanced
incorporation
large
molecules,
using
cytochrome
C
as
model.
Due
varying
surface
charge
depending
on
pH,
pH-dependent
control
was
obtained
between
pH
2.5
7.5,
maximum
acidic
conditions.
Therefore,
mesoporosity
could
be
printed,
acting
stimuli
responsive
platform
therapeutic
potential.
Language: Английский
Synthesis, thermal, and mechanical characterisation of metakaolin-based geopolymers coloured with grape marc extract
Journal of Thermal Analysis and Calorimetry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 24, 2024
Abstract
Over
the
years,
several
materials
have
been
used
for
restoration
purposes,
with
different
types
of
dyes
and
colour
hues.
Recently,
some
researchers
proposed
geopolymers
(GPs)
or
amorphous
aluminosilicate
polymers
these
purposes.
In
this
work,
an
alcohol-based
grape
marc
extract
(GME,
obtained
via
dark
maceration
assisted
ultrasound)
was
as
a
natural
dyeing
agent
metakaolin-based
GPs.
The
geopolymerisation
occurrence
assessed
by
Fourier-transform
infrared
(FT-IR)
spectroscopy
X-ray
diffraction
analysis,
while
resulting
material
determined
through
colorimetric
analysis
in
L
*
b
space.
Additionally,
thermal
stability
GME
GPs
investigated
thermogravimetry
coupled
FT-IR
spectroscopy.
microstructure,
reticulation
stability,
antimicrobial
activity
were
examined
scanning
electron
microscopy,
pH
ionic
conductivity
measurements,
integrity,
mass
loss
tests.
Overall,
coloured
geopolymer
suitable
thermal,
antimicrobial,
mechanical
properties
obtained,
justifying
its
potential
use
or,
more
generally,
construction
field.
Graphical
abstract
Language: Английский
Characterization of Grape Extract-Colored SiO2 Synthesized via the Sol–Gel Method
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(24), P. 11697 - 11697
Published: Dec. 15, 2024
Numerous
studies
have
focused
on
the
development
of
active
packaging
using
plastics,
but
glass-based
represents
a
more
sustainable
alternative,
offering
advantages
in
terms
recyclability,
durability,
and
reduced
environmental
footprint.
This
study
proposes
system
by
incorporating
anthocyanins-rich
grape
extract
(GRE)
into
silica
(SiO2)
matrix
sol–gel
method.
GRE
was
added
at
two
concentrations,
5%
(S5GRE)
15%
(S15GRE).
During
synthesis,
color
brightening
occurred
as
anthocyanins
shifted
to
colorless
chalcone
pseudo-base
forms,
colorimetric
analysis
confirmed
that
hybrid
materials
retained
red
hue
after
gel
drying.
Fourier-transform
infrared
(FTIR)
thermogravimetric
(TGA/DTG)
investigated
stability
within
showed
both
hybrids
formed
hydrogen
bonds
with
inorganic
matrix.
However,
S5GRE
exhibited
better
thermal
compared
S15GRE,
possibly
due
greater
proportion
being
fully
entrapped
rather
than
surface-bound.
The
encapsulation
efficiency
supported
this,
showing
98.12%
successfully
S5GRE,
whereas
S15GRE
only
54.62%.
These
results
indicate
that,
while
exhibits
higher
allows
for
faster
release,
releases
less
efficiently
aggregation
Language: Английский