The hardware, tracer, and signal processing methods of magnetic particle imaging: A review DOI

Angga Davida,

Basari Basari

Journal of Applied Physics, Journal Year: 2024, Volume and Issue: 136(22)

Published: Dec. 12, 2024

Magnetic Particle Imaging (MPI) has advanced rapidly from its first conceptualization, showing promise as a viable clinical imaging modality. Despite promise, several aspects of MPI, such hardware design, tracer and image reconstruction method, still require further technical development to overcome their current limitations. This review provides the basic concept for introduces limitations upscaling discusses MPI development. Among them are advantages disadvantages using different field-free regions (FFR), bore configurations, elaborating on challenges in upscaling, describing optimal characteristics tracers, discussing synthesis methods biocompatible coatings, toxicity reports, finally explanation regarding various methods. Additionally, this examples state-of-the-art devices prototypes with varying designs, FFR magnetic field sources, intended use cases demonstrate both wide range applications progress recent research MPI. With all information compiled, serves shed insight researchers or those intending enter world It is hoped that will encourage future accelerating viability implementation.

Language: Английский

Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies DOI Creative Commons
Ewelina Musielak, Violetta Krajka‐Kuźniak

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

Citations

3
A review of the latest advancements in using β-cyclodextrin-based as supramolecular catalysts for Heck reactions DOI
Sara Payamifar, Majid Abdouss, Shahrzad Javanshir

et al.

Carbohydrate Research, Journal Year: 2025, Volume and Issue: 550, P. 109381 - 109381

Published: Jan. 13, 2025

Language: Английский

Citations

2
From lab to field: Prussian blue frameworks as sustainable cathode materials DOI
Yedluri Anil Kumar, Siva Sankar Sana, Tholkappiyan Ramachandran

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(26), P. 10770 - 10804

Published: Jan. 1, 2024

Prussian blue and analogues have attracted increasing attention as versatile framework materials with a wide range of applications in catalysis, energy conversion storage, biomedical environmental fields.

Language: Английский

Citations

15
Magnetic Nanoparticles: A Comprehensive Review from Synthesis to Biomedical Frontiers DOI

Shlok Mishra,

Manishkumar D. Yadav

Langmuir, Journal Year: 2024, Volume and Issue: 40(33), P. 17239 - 17269

Published: Aug. 12, 2024

Nanotechnology has opened new doors of exploration, particularly in materials science and healthcare. Magnetic nanoparticles (MNP), the tiny magnets, because their various properties, have potential to bring about radical changes field medicine. The distinctive surface chemistry, nontoxicity, biocompatibility, and, particular, inducible magnetic moment attracted a great deal interest morphological structures from variety scientific domains. This review presents concise overview MNPs crucial properties synthesis routes. It also aims highlight continuous methods available for MNP production. In recent years, use computational understanding behavior been on rise. Thus, we discuss numerical models developed understand how can be used hyperthermia targeting Circle Wilis. With increasing biomedical applications, it becomes necessary mechanisms toxicity, which are elucidated this review. focuses applications drug delivery, theranostics, MRI contrasting agents. We anticipate that article will broaden perspective help functionality applicability better.

Language: Английский

Citations

12
Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems DOI Creative Commons
Sivakumar S. Moni, Jobran M. Moshi, Sabine Matou‐Nasri

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 296 - 296

Published: Feb. 24, 2025

Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.

Language: Английский

Citations

1
Enhanced Biodiesel Production with Eversa Transform 2.0 Lipase on Magnetic Nanoparticles DOI Creative Commons
Kaiany Moreira dos Santos,

Juliana de França Serpa,

Viviane de Castro Bizerra

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

This research investigated the usefulness of magnetic iron oxide nanoparticles (Fe3O4) as a support to immobilize lipase Eversa Transform 2.0 (ET 2.0) obtain an active and stable biocatalyst, easily recoverable from reaction medium for applications in production biodiesel. Biodiesel was alternative fuel composed mainly fatty acid esters with strong transesterification esterification capabilities. The study focused on oleic ethanol synthesize ethyl oleate. Magnetic were prepared by coprecipitation, then activated glutaraldehyde functionalized γ-aminopropyltriethoxysilane (APTES). optimal conditions immobilizing ET pH 10, 25 mM sodium carbonate buffer, enzymatic load 200 U/g, 1 h contact time, obtaining 78% yield activity 205.9 U/g. Postimmobilization evaluation showed that immobilized enzyme performed better than its free form. Kinetic studies conducted under these optimized (2–96 at 150 rpm 37 °C). biocatalyst tested synthesis oleate using substrate ethanol, achieving conversion 88.1%. Subsequent recirculation tests maintained approximately 80% until fourth cycle, confirming sustainability ester production. Molecular docking revealed binding affinity enzyme-docked oil composition estimated −5.8 kcal/mol, suggesting combination suitable esterification.

Language: Английский

Citations

6
Optimum Saturation Magnetization of Superparamagnetic Iron Oxide Nanoparticles for Versatile Applications DOI Creative Commons

Öznur Karaağaç,

H. C. Hasirci

Acta Physica Polonica A, Journal Year: 2024, Volume and Issue: 146(2), P. 154 - 164

Published: Aug. 1, 2024

Language: Английский

Citations

4
Recent Advances in the Tunable Optoelectromagnetic Properties of PEDOTs DOI Creative Commons
Ling Zhu,

Qi Liu,

Y L Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 179 - 179

Published: Jan. 4, 2025

Conducting polymers represent a crucial class of functional materials with widespread applications in diverse fields. Among these, poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have garnered significant attention due to their distinctive optical, electronic, magnetic properties, as well exceptional tunability. These properties often exhibit intricate interdependencies, manifesting synergistic, concomitant, or antagonistic relationships. In optics, PEDOTs are renowned for high transparency unique photoelectric responses. From an electrical perspective, they display conductivity, thermoelectric, piezoelectric performance, along notable electrochemical activity stability, enabling wide array electronic applications. terms demonstrate outstanding electromagnetic shielding efficiency microwave absorption capabilities. Moreover, these can be precisely tailored through molecular structure modifications, chemical doping, composite formation suit various application requirements. This review systematically examines the mechanisms underlying optoelectromagnetic PEDOTs, highlights tunability, outlines prospective research directions. By providing critical theoretical insights technical references, this aims advance landscape PEDOTs.

Language: Английский

Citations

0
A Compendium of Magnetic Nanoparticle Essentials: A Comprehensive Guide for Beginners and Experts DOI Creative Commons
Carlos O. Amorim

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 137 - 137

Published: Jan. 20, 2025

Magnetic nanoparticles (MNPs) are advanced materials that combine the unique properties of magnetic and nanoscale dimensions, enabling a wide range applications in biomedicine, environmental science, information technology. This review provides comprehensive yet accessible introduction to fundamental principles, characterization techniques, diverse MNPs, with focus on their properties, such as superparamagnetism, single-domain behavior, surface effects. It also delves into classification critical role parameters like anisotropy blocking temperature. Emphasis is placed routine methods, including X-ray diffraction, electron microscopy, magnetometry, well concepts hyperthermia self-regulated heating. Designed for newcomers experts alike, this serves both an educational guide quick-reference resource, ensuring clarity while maintaining scientific rigor.

Language: Английский

Citations

0
Magnetic Nanoparticles: Advances in Synthesis, Sensing, and Theragnostic Applications DOI Creative Commons
Adeyemi Ojutalayo Adeeyo, Mercy Adewumi Alabi, Joshua Akinropo Oyetade

et al.

Magnetochemistry, Journal Year: 2025, Volume and Issue: 11(2), P. 9 - 9

Published: Jan. 26, 2025

The synthesis of magnetic nanoparticles (MNPs) via the chemical, biological, and physical routes has been reported on along with advantages attendant limitations. This study focuses sensing emerging theragnostic applications this category (NPs) in clinical sciences by unveiling unique performance these NPs biological bacteria nucleotide sequencing. Also, terms medicine science, review analyzes drug delivery, bone tissue engineering, deep brain stimulation, therapeutic hyperthermia, tumor detection, imaging cell tracking, lymph node visualization, blood purification, COVID-19 detection. presents succinct surface functionalization coating techniques to confer less toxicity biocompatibility during synthesis, which are often identified as limitations medical applications. also indicates that improvement useful for refining selective activity MNPs their use sensors biomarkers. In addition, unveils limitations, especially toxicological impacts biomolecules, suggests future research should pay attention mitigation biotoxicity MNPs. Thus, a proficient approach high-performance fit detection microorganisms, better diagnosis, treatment medicine.

Language: Английский

Citations

0