Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5382 - 5382

Published: March 11, 2023

Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated oxidation stress, with some forms of providing protective effects. The reaction involves the alkene bonds, primarily in polyunsaturated fatty acids, chain form radical reactive oxygen species (ROS). reactions typically affect cellular membranes through direct effects on membrane structure function as well impacting other functions due increases ROS. Although mitochondrial have been studied detail, components organelles are affected. Because complexes induce ROS formation both directly indirectly, study arising from increased should include investigations processes. This made more challenging range exist under physiological conditions diverse these species. Thus, complex chemistry requires speciation studies evaluate indirect various present during exposure. Undoubtedly, important assessing how exerts biological systems likely underlying cause for beneficial reported cancerous, diabetic, neurodegenerative diseased tissues impacted Speciation vanadium, together LPO, considered future evaluating cells, tissues, organisms discussed this review.

Language: Английский

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Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.

Language: Английский

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Polyoxometalates Impact as Anticancer Agents

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 5043 - 5043

Published: March 6, 2023

Polyoxometalates (POMs) are oxoanions of transition metal ions, such as V, Mo, W, Nb, and Pd, forming a variety structures with wide range applications. Herein, we analyzed recent studies on the effects polyoxometalates anticancer agents, particularly their cell cycle. To this end, literature search was carried out between March June 2022, using keywords "polyoxometalates" "cell cycle". The POMs selected lines can be diverse, in cycle, protein expression, mitochondrial effects, reactive oxygen species (ROS) production, death viability. present study focused viability cycle arrest. Cell by dividing into sections according to constituent compound, namely polyoxovanadates (POVs), polyoxomolybdates (POMos), polyoxopaladates (POPds) polyoxotungstates (POTs). When comparing sorting IC50 values ascending order, obtained first POVs, then POTs, POPds and, finally, POMos. clinically approved drugs POMs, better results relation were observed many cases, since dose required have an inhibitory concentration 50% is 2 200 times less, depending highlighting that these compounds could become future alternative existing cancer therapy.

Language: Английский

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The future of polyoxymetalates for biological and chemical apllications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 493, P. 215306 - 215306

Published: June 20, 2023

Language: Английский

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Polyoxometalate nanocluster-infused triple IPN hydrogels for excellent microplastic removal from contaminated water: detection, photodegradation, and upcycling

Nanoscale, Journal Year: 2024, Volume and Issue: 16(10), P. 5188 - 5205

Published: Jan. 1, 2024

Microplastic (MP) pollution threatens ecosystems globally, necessitating urgent environmental intervention. This article proposes a solution for combating MP in water by an innovative hydrogel synthesis and circular economy-based upcycling.

Language: Английский

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Decavanadate and metformin-decavanadate effects in human melanoma cells

Journal of Inorganic Biochemistry, Journal Year: 2022, Volume and Issue: 235, P. 111915 - 111915

Published: July 8, 2022

Decavanadate is a polyoxometalate (POMs) that has shown extensive biological activities, including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as well biguanide drugs, such metformin, have to exert therapeutic effects in melanoma. A combination of these agents, the metformin-decavanadate complex, was also recognized for its recently described better treatment than monotherapy with metformin enabling lower dosage rodent models diabetes. Herein, we compare decavanadate on Ca2+-ATPase activity sarcoplasmic reticulum vesicles from rabbit skeletal muscles cell signaling events viability human melanoma cells. We show unlike decavanadate-mediated non-competitive mechanism, inhibits by mixed-type competitive-non-competitive inhibition an IC50 value about 6 times higher (87 μM) previously (15 μM). found both antiproliferative cells at 10 concentrations monomeric vanadate. Western blot analysis revealed both, increased phosphorylation extracellular signal-regulated kinase (ERK) serine/threonine protein AKT proteins upon 24 h drug exposure, suggesting anti-proliferative activities act independent growth-factor pathways.

Language: Английский

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Commentary on the role of polyoxometalates in nature cybernetic loop

Natural Sciences, Journal Year: 2024, Volume and Issue: 4(2-3)

Published: Jan. 4, 2024

Abstract The interplay between extraterrestrial, atmospheric, aqueous, interfacial, and hydrothermal processes is crucial for Earth's prebiotic chemistry. Volcanic terrains contain polyoxometalates (POMs). Some polyoxocuprates were identified as building blocks of fumarole minerals produced from high‐temperature gases. existence polyoxovanadate anions in acidified reducing volcanic aquifers cannot be excluded. At present, it can only speculated whether life arose around natural POM deposits and/or their aqueous phase chemistry through acid‐base redox reactions. This Commentary spans different fields sciences nature cybernetic loop to provide impetus explore gas‐phase chemical reactions multiply charged ions, catalysis by POM‐containing mineral phases, the behavior POMs under plasma‐initiated ultraviolet photolysis, interactions with microorganisms, bioorthogonal POMs, engineering POM‐based bionic functions inspired living organisms.

Language: Английский

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Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(31)

Published: June 6, 2024

The high-resolution X-ray structures of the model protein lysozyme in presence potential drug [V

Language: Английский

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Reusable and Highly Active Copper-Based Lacunary-type Polyoxometalate (LPMo-Cu) as an Effective Catalyst for Nitroarene Reduction in Aqueous Solution

Langmuir, Journal Year: 2023, Volume and Issue: 39(24), P. 8484 - 8493

Published: June 6, 2023

Lacunary polyoxometalates (LPOMs), a class of anionic metal oxide clusters, are promising materials as catalysts, photocatalysts, and electrocatalysts. Designing functionalizing this type compound key factors for the discovery development novel materials. Herein, new lacunary polyoxometalate-based was designed heterogeneous catalyst, prepared through functionalization Keggin-type polyoxometalate, i.e., [PMo11O39]7-, with 3-aminopropyltrimethoxysilane (APTS) 2-pyridine carboxaldehyde. Subsequent reactions Cu2+ ions led to desired LPMo-Cu. The catalytic activity obtained LPMo-Cu examined in nitroarene reduction using sodium borohydride reducing agent aqueous solution. It specified that synthesized exhibits high efficiency wide variety nitroarenes short time (5 min). Furthermore, stability recoverability material were proved result four consecutive cycles without significant decrease its efficiency.

Language: Английский

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The Preyssler-Type Polyoxotungstate Exhibits Anti-Quorum Sensing, Antibiofilm, and Antiviral Activities

Biology, Journal Year: 2022, Volume and Issue: 11(7), P. 994 - 994

Published: June 30, 2022

The increase in bacterial resistance to antibiotics has led researchers find new compounds or combinations between different with potential antibacterial action and the ability prevent development of antibiotic resistance. Polyoxotungstates (POTs) are inorganic clusters that may fulfill need, either individually combination antibiotics. Herein, we report polyoxotungstates Wells-Dawson P2W18, P2W17, P2W15, Preyssler P5W30 type structures differently affect Gram-negative Gram-positive microorganisms, susceptible resistant compound showed highest activity against majority tested strains comparison other POTs (P2W15, P2W17 P2W18) did not show inhibition zones for bacteria, A. baumanii I73775, E. coli DSM 1077, I73194, K. pneumoniae I7092374, P. aeruginosa C46281). Generally, results evidenced bacteria more tested. was one most active S. aureus ATCC 6538 MRSA16, reaching <0.83 mg·mL−1 (100 μM) 4.96 (600 μM), respectively. Moreover, it verified by NMR spectroscopy promising POT, P5W30, remains intact under all experimental conditions, after 24 h at 37 °C. This prompted us further evaluate anti-quorum sensing using biosensor Chromobacterium violaceum CV026, as well its antibiofilm both cefoxitin methicillin-resistant Staphylococcus 16 (MRSA16). a synergistic effect chloramphenicol MRSA16. pronounced when used individually, cefoxitin. Finally, antiviral coliphage Qβ, showing dose-dependent response. maximum inactivation observed 750 μM (6.23 mg·mL−1). In sum, shows activities besides being potent agent exhibit enteric viruses.

Language: Английский

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