Artificial Intelligence for Personalized Genetics and New Drug Development: Benefits and Cautions DOI Creative Commons
Crescenzio Gallo

Bioengineering, Journal Year: 2023, Volume and Issue: 10(5), P. 613 - 613

Published: May 19, 2023

As the global health care system grapples with steadily rising costs, increasing numbers of admissions, and chronic defection doctors nurses from profession, appropriate measures need to be put in place reverse this course before it is too late [...].

Language: Английский

Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration DOI
Mohamadreza Tavakoli, Mastafa H. Al-Musawi,

Alma Kalali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130954 - 130954

Published: March 16, 2024

Language: Английский

Citations

29

Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications DOI Creative Commons
Arnaud Kamdem Tamo

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759

Published: Jan. 1, 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Language: Английский

Citations

23

Biodegradable Polymers in Biomedical Applications: A Review—Developments, Perspectives and Future Challenges DOI Open Access
Jagoda Kurowiak, Tomasz Klekiel, Romuald Będziński

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16952 - 16952

Published: Nov. 29, 2023

Biodegradable polymers are materials that, thanks to their remarkable properties, widely understood be suitable for use in scientific fields such as tissue engineering and engineering. Due the alarming increase number of diagnosed diseases conditions, great interest biomedical applications especially. The biodegradable biomedicine is constantly expanding. application new techniques or improvement existing ones makes it possible produce with desired mechanical strength, controlled degradation time rate antibacterial antimicrobial properties. In addition, these can take virtually unlimited shapes a result appropriate design. This additionally desirable when necessary develop structures that support restore proper functioning systems body.

Language: Английский

Citations

26

Multiscale embedded printing of engineered human tissue and organ equivalents DOI
Cheng Zhang, Weijian Hua, Kellen Mitchell

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 12, 2024

Creating tissue and organ equivalents with intricate architectures multiscale functional feature sizes is the first step toward reconstruction of transplantable human tissues organs. Existing embedded ink writing approaches are limited by achievable ranging from hundreds microns to tens millimeters, which hinders their ability accurately duplicate structures found in various In this study, a printing (MSEP) strategy developed, stimuli-responsive yield-stress fluid applied facilitate process. A dynamic layer height control method developed print cornea smooth surface on order microns, can effectively overcome layered morphology conventional extrusion-based three-dimensional bioprinting methods. Since support bath sensitive temperature change, it be easily removed after tuning ambient temperature, facilitates fabrication eyeballs optic nerves aortic heart valves overhanging leaflets few millimeters. The thermosensitivity also enables full-scale centimeters on-demand adding materials during printing. proposed MSEP demonstrates broader printable centimeters, providing viable reliable technical solution for future.

Language: Английский

Citations

11

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes DOI Creative Commons
M. Zohaib Iqbal,

Mahrukh Riaz,

Thomas Biedermann

et al.

Angiogenesis, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve transplantation. However, establishing an adequate and rapid vascularization in TESS is critical factor for their clinical application successful engraftment patients. Therefore, several methods have been applied the of including (i) modifying structural physicochemical properties dermal scaffolds; (ii) activating biological scaffolds with growth factor-releasing systems or gene vectors; (iii) developing prevascularized by loading capillary-forming cells. This review provides detailed overview most recent important developments strategies substitutes. On one hand, we present cell-based approaches using stem cells, microvascular fragments, adipose tissue derived stromal vascular fraction, endothelial cells from blood well other pro-angiogenic stimulation methods. discuss how distinct 3D bioprinting techniques microfluidics, miRNA manipulation, cell sheet engineering photosynthetic like GelMA, can enhance applications. Finally, summarize challenges prospects currently available that may serve steppingstone mainstream engineering. Graphical abstract

Language: Английский

Citations

9

Recent Advances in the Development of Biomimetic Materials DOI Creative Commons
Maria Gessica Ciulla, Alessio Massironi, Michela Sugni

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(10), P. 833 - 833

Published: Oct. 20, 2023

In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments tissue functions, but many aspects regarding cellular communication, motility, responsiveness remain be explained. We photographed state-of-the-art advancements biomimetics, discussed complexity a “bottom-up” artificial construction living systems, particular highlights hydrogels, collagen-based composites, surface modifications, three-dimensional (3D) bioprinting applications. Fast-paced 3D printing intelligence, nevertheless, collide reality: How difficult can it build reproducible at real scale line systems? Nowadays, science is urgent need bioengineering technologies for practical use bioinspired biomimetics medicine clinics.

Language: Английский

Citations

19

Bioink Formulations for 3D Printing of Tissue Scaffolds: A Review of Materials and Printability DOI

Faithfulness O. Osazee,

Andrew O. Ohifuemen,

Jeffery I. Omoruyi

et al.

˜The œminerals, metals & materials series, Journal Year: 2024, Volume and Issue: unknown, P. 484 - 499

Published: Jan. 1, 2024

Language: Английский

Citations

6

Engineering innovations in medicine and biology: Revolutionizing patient care through mechanical solutions DOI Creative Commons
Eddie Gazo Hanna, Khaled Younes, Rabih Roufayel

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e26154 - e26154

Published: Feb. 1, 2024

The overlap between mechanical engineering and medicine is expanding more over the years. Engineers are now using their expertise to design create functional biomaterials continually collaborating with physicians improve patient health. In this review, we explore state of scientific knowledge in areas biomaterials, biomechanics, nanomechanics, computational fluid dynamics (CFD) relation pharmaceutical medical industry. Focusing on current research breakthroughs, provide an overview how these fields being used new technologies for treatments human patients. Barriers constraints fields, as well ways overcome them, also described review. Finally, potential future advances fundamentally change approach biology discussed.

Language: Английский

Citations

5

Advancements in 3D Skin Bioprinting: Processes, Bioinks, Applications and Sensor Integration DOI Creative Commons
İrem Deniz Derman,

T. Pinedo Rivera,

Laura Garriga-Cerda

et al.

International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 7(1), P. 012009 - 012009

Published: Oct. 16, 2024

Abstract This comprehensive review explores the multifaceted landscape of skin bioprinting, revolutionizing dermatological research. The applications bioprinting utilizing techniques like extrusion-, droplet-, laser- and light-based methods, with specialized bioinks for biofabrication have been critically reviewed along intricate aspects hair follicles, sweat glands, achieving pigmentation. Challenges remain need vascularization, safety concerns, integration automated processes effective clinical translation. further investigates incorporation biosensor technologies, emphasizing their role in monitoring enhancing wound healing process. While highlighting remarkable progress field, critical limitations concerns are examined to provide a balanced perspective. synthesis aims guide scientists, engineers, healthcare providers, fostering deeper understanding current state, challenges, future directions transformative tissue engineering regenerative medicine.

Language: Английский

Citations

5

Data-Driven Future Trends and Innovation in Telemedicine DOI
Wasswa Shafik

Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 93 - 118

Published: March 27, 2024

This study examines the future of telemedicine by investigating influence developing technologies on healthcare. It emphasizes need to comprehend impact these advancements healthcare provision, given their swift progression. The debate encompasses a range technologies, including internet things (IoT) devices, artificial intelligence (AI), augmented reality (AR), robotics, blockchain, virtual (VR), genomics, and wearable tech within settings. highlights capacity for patient monitoring, diagnosis, tailored therapy, improved access Furthermore, it tackles legal, privacy, ethical issues linked breakthroughs ongoing study, collaboration, strong regulation exploit capabilities fully.

Language: Английский

Citations

4