Micromachines,
Journal Year:
2021,
Volume and Issue:
12(7), P. 808 - 808
Published: July 9, 2021
In
this
research,
glassy
carbon
electrode
(GCE)
amplified
with
single-wall
nanotubes
(SWCNTs)
and
ds-DNA
was
fabricated
utilized
for
voltammetric
sensing
of
doxorubicin
a
low
detection
limit.
technique,
the
reduction
in
guanine
signal
presence
(DOX)
chosen
as
an
analytical
factor.
The
molecular
docking
study
revealed
that
drug
interacted
DNA
through
intercalation
mode,
which
agreement
obtained
experimental
results.
DOX
performance
ds-DNA/SWCNTs/GCE
assessed
at
concentration
range
1.0
nM–20.0
µM.
limit
found
to
be
0.6
nM
comparable
even
better
(in
many
cases)
than
previous
electrochemical
reported
sensors.
final
step,
showed
powerful
ability
determination
injection
samples
acceptable
recovery
data.
Pakistan Veterinary Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
research
aimed
to
investigate
whether
the
combination
of
L-carnitine
(LC)
and
thymoquinone
(TQ)
could
lower
adverse
effects
methotrexate
(MTX),
a
widely
used
chemotherapy
agent
in
cancer
therapy,
on
testicular
function.A
total
seven
groups
were
established
(n=7);
control
group,
LC
(200
mg/kg
PO),
TQ
(50
MTX
(single
IP
dose
20
mg/kg),
LC+MTX,
TQ+MTX,
LC+TQ+MTX.The
use
resulted
levels
testosterone,
folliclestimulating
hormone
(FSH),
luteinizing
(LH)
blood,
accompanied
by
significant
rise
MDA
levels.Additionally,
there
was
notable
decline
GSH,
CAT,
SOD,
indicating
reduced
antioxidant
activity
testicles.Furthermore,
histopathological
examination
testicles
revealed
disruptions
caused
MTX,
expression
caspase-3
documented.The
with
significantly
increased
FSH,
LD
restored
oxidative
damage
markers
(p<0.05)
improved
scores
expression.In
conclusion,
our
results
demonstrate
that
exhibit
substantial
protective
against
toxicity
induced
primarily
attributed
their
properties.
Micromachines,
Journal Year:
2021,
Volume and Issue:
12(7), P. 808 - 808
Published: July 9, 2021
In
this
research,
glassy
carbon
electrode
(GCE)
amplified
with
single-wall
nanotubes
(SWCNTs)
and
ds-DNA
was
fabricated
utilized
for
voltammetric
sensing
of
doxorubicin
a
low
detection
limit.
technique,
the
reduction
in
guanine
signal
presence
(DOX)
chosen
as
an
analytical
factor.
The
molecular
docking
study
revealed
that
drug
interacted
DNA
through
intercalation
mode,
which
agreement
obtained
experimental
results.
DOX
performance
ds-DNA/SWCNTs/GCE
assessed
at
concentration
range
1.0
nM–20.0
µM.
limit
found
to
be
0.6
nM
comparable
even
better
(in
many
cases)
than
previous
electrochemical
reported
sensors.
final
step,
showed
powerful
ability
determination
injection
samples
acceptable
recovery
data.
