Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases

Chemosphere, Journal Year: 2022, Volume and Issue: 307, P. 136020 - 136020

Published: Aug. 16, 2022

Language: Английский

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Nanoparticle-Based Drug Delivery Systems: An Inspiring Therapeutic Strategy for Neurodegenerative Diseases

Polymers, Journal Year: 2023, Volume and Issue: 15(9), P. 2196 - 2196

Published: May 5, 2023

Neurodegenerative diseases are common, incurable neurological disorders with high prevalence, and lead to memory, movement, language, intelligence impairments, threatening the lives health of patients worldwide. The blood–brain barrier (BBB), a physiological between central nervous system peripheral blood circulation, plays an important role in maintaining homeostasis intracerebral environment by strictly regulating transport substances brain. Therefore, it is difficult for therapeutic drugs penetrate BBB reach brain, this affects their efficacy. Nanoparticles (NPs) can be used as drug carriers also known nanoparticle-based delivery systems (NDDSs). These not only increase stability but facilitate crossing through improve In article, we provided overview types administration routes NPs, highlighted preclinical clinical studies NDDSs neurodegenerative diseases, summarized combined strategies management diseases. Finally, prospects challenges recent basic research were discussed. Above all, provide inspiring strategy treatment

Language: Английский

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Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases

British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 180(12), P. 1542 - 1561

Published: Feb. 16, 2023

Mitochondria and mitochondria-mediated signalling pathways are known to control synaptic signalling, as well long-lasting changes in neuronal structure function. Mitochondrial impairment is linked dysfunction normal ageing age-associated neurodegenerative ailments, including Parkinson's disease (PD) Alzheimer's (AD). Both proteolysis mitophagy perform a major role neuroprotection, by maintaining healthy mitochondrial population during ageing. Mitophagy, highly evolutionarily conserved cellular process, helps the clearance of damaged mitochondria thereby maintains metabolic balance, energy supply, survival health. Besides maintenance brain homeostasis, hippocampal also synapse formation, axonal development, dopamine release long-term depression. In contrast, defective contributes age-related neurodegeneration promoting accumulation leading dysfunction. Exercise, stress management, dynamics administering natural or synthetic pharmacological compounds some strategies used for neuroprotection neurological diseases. The current review discusses impact conditions, underlying molecular potential therapies based on recently elucidated mitophagy-inducing strategies.

Language: Английский

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Some promising medicinal plants used in Alzheimer’s disease: an ethnopharmacological perspective

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(5)

Published: April 16, 2024

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily associated with aging. This devastating condition characterized by significant memory loss, abnormal behavior, personality shifts, and decline in cognitive function. Despite extensive research, no cure for currently exists, available treatment options have shown limited effectiveness. Developing therapeutic interventions to slow down or prevent the onset progression of crucial address growing burden this condition. Ayurvedic medicinal herbs emerged as promising avenue drug numerous compounds derived from these undergoing clinical trials. Scientific studies explored potential application various plants their derivatives disease. Although precise mechanisms action remain largely unknown, phytochemical investigations identified wide range beneficial within plants. These include lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, alkaloids, each exhibiting diverse pharmacological activities. activities encompass anti-inflammatory, anti-amyloidogenic, anticholinesterase, hypolipidemic, antioxidant effects. review highlights phytochemistry ethnomedicinal applications plants, along bioactive compounds. It underscores Ayurveda, one world’s oldest holistic healing systems, identifying effective disorders like The constituents suggest novel treatments findings offer hope addressing challenges posed debilitating Graphical

Language: Английский

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Unraveling the therapeutic potential of quercetin and quercetin-3-O-glucuronide in Alzheimer's disease through network pharmacology, molecular docking, and dynamic simulations

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 27, 2024

Abstract Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. plays significant role in neuroinflammation, which helps reduce Alzheimer's disease (AD) severity. (Q) quercetin 3-O-glucuronide (Q3OG) are some of the most potent antioxidants available from natural sources. However, form converted into Q3OG when reacted intestinal microbes. The study aims to ensure potential Q Q3OG. In this study, molecular targets were first identified using Swiss Target Prediction platform pathogenic AD DisGeNET database. Followed by compound target overlapping, 77 placed that AKT1, EGFR, MMP9, TNF, PTGS2, MMP2, IGF1R, MCL1, MET PARP1 was top-ranked target, estimated CytoHubba plug-in. Molecular docking performed for towards PDB:1UNQ target. binding score − 6.2 kcal/mol 6.58 respectively. dynamics simulation conducted at 200 ns. This study's results help identify multiple sites bioactive compounds. Thus, synthesizing new chemical entity-based on structural modification may aid eradicating complications.

Language: Английский

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Exposure of metal toxicity in Alzheimer’s disease: An extensive review

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 29, 2022

Metals serve important roles in the human body, including maintenance of cell structure and regulation gene expression, antioxidant response, neurotransmission. High metal uptake nervous system is harmful because it can cause oxidative stress, disrupt mitochondrial function, impair activity various enzymes. Metal accumulation lifelong deterioration, severe neurological problems. There a strong association between accidental exposure neurodegenerative disorders, Alzheimer’s disease (AD), most common form dementia that causes degeneration aged. Chronic to metals well-known environmental risk factor has become more widespread due rapid pace at which activities are releasing large amounts into environment. Consequently, humans exposed both biometals heavy metals, affecting homeostasis molecular biological levels. This review highlights how these affect brain physiology immunity their creating proteins such as β-amyloid tau AD. In addition, we address findings confirm disruption immune-related pathways significant toxicity mechanism through may contribute

Language: Английский

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Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 16

Published: June 21, 2022

Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in recent decades to greater extent. Since the incidence severity of disease are constantly increasing, plenty therapeutic approaches being considered as promising solution. Many dietary polyphenols have been reported be effective against diabetes along with accompanying vascular consequences by targeting multiple targets. Additionally, biocompatibility these raises questions about their use pharmacological mediators. Nevertheless, pharmacokinetic biopharmaceutical properties limit clinical benefit therapeutics. Pharmaceutical industries attempted improve compliance effects. However, nanotechnological overcome barriers associated antidiabetic medications shown efficacy. Therefore, this review highlighted comprehensive up-to-date assessment polyphenol nanoformulations treatment consequences.

Language: Английский

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Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 22

Published: Aug. 18, 2022

Tacrine is a drug used in the treatment of Alzheimer’s disease as cognitive enhancer and inhibitor enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to poor therapeutic efficacy high prevalence detrimental effects. An attempt was made understand molecular mechanisms that underlie tacrine analogues influence over neurotherapeutic activity by focusing on modulation neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, regulatory role gene protein expression, energy metabolism, Ca2+ homeostasis modulation, osmotic regulation. Regardless this, are considered model cholinesterase therapy disease. The variety both structural make-up biological functions these substances main appeal for researchers’ interest them. A new paradigm treating neurological diseases presented this review, which includes strategies disease, well other disorders like Parkinson’s synthesis properties newly identified versatile hybrids. We have also shown may promise experimental systems.

Language: Английский

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Biomaterials Comprising Implantable and Dermal Drug Delivery Targeting Brain in Management of Alzheimer’s Disease: A Review

Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Language: Английский

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Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105867 - 105867

Published: Aug. 28, 2024

Neurodegenerative diseases (NDDs) are a series of disorders characterized by the progressive loss specific neurons, leading to cognitive and locomotor impairment. NDDs affect millions patients worldwide but lack effective treatments. Dysregulation lipids, particularly accumulation lipid droplets (LDs), is strongly implicated in pathogenesis NDDs. How LDs contribute occurrence development NDDs, their potential as therapeutic targets remain be addressed. In present review, we first introduce processes formation, transportation degradation. We then highlight how contributes cell type-specific manner. Moreover, discuss currently available methods for detecting elaborate on LDs-based strategies Lastly, identify gaps that need filled better leverage LD-based theranostics other diseases. hope this review could shed light role facilitate novel

Language: Английский

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