Long-term food supplementation with sweet basil (Ocimum basilicum L.) prevents age-associated cognitive decline in female mice DOI
Dâmaris Costa Miranda Pires, Alberto da Silva Moraes

Nutrition and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Background: Mild cognitive decline, a common issue in aging, affects memory, learning, and attention. Nutrition can influence cognition, research indicates that Ocimum sp. (holy basil sweet basil) leaf extracts may enhance cognition rodents humans. However, these studies do not address whether benefits extend to fresh or dry leaves consumed typical human diets, along with physiological aging. Aim: To investigate the effects of supplementation on mature aged female mice. Methods: Female C57bl mice were divided into four groups: 8-month-old adults 18-month-old adults, each receiving either control supplemented diet. The diet included mix standard chow leaves, administered for 2–8 months. Cognitive behavioral assessments conducted using novel object recognition (NOR), Morris water maze (MWM), elevated plus (EPM) tasks, focusing anxiety. Results: No improvement was observed long-term showed enhanced discrimination NOR stayed closer absent platform MWM compared nonsupplemented controls. While aging exhibited reduced anxiety-like behavior EPM, prevented this reduction. Conclusion: Basil appears beneficial elderly mice, potentially preventing age-related decline changes. These findings support consumption underscore its potential role promoting healthy Incorporating at younger age preserve memory mitigate changes as individuals age.

Language: Английский

The phytochemical, proximate, pharmacological, GC-MS analysis of Cyperus esculentus (Tiger nut): A fully validated approach in health, food and nutrition DOI
Laurine Chikodiri Nwosu, Great Iruoghene Edo, Erkay Özgör

et al.

Food Bioscience, Journal Year: 2022, Volume and Issue: 46, P. 101551 - 101551

Published: Jan. 10, 2022

Language: Английский

Citations

95
Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight DOI Creative Commons
Syed Nasir Abbas Bukhari

Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 554 - 554

Published: March 15, 2022

Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers phenol acid, isoflavonoids possess hidden health promoting characteristics, antioxidative, anti-aging, anti-cancerous many more. The use combating the neuropathological war raging this generation is currently hotly debated topic. Lately, Alzheimer's disease (AD) emerging most common disease, destroying livelihoods millions one way another. Any therapeutic intervention to curtail its advancement come has been vain date. Using dietary construct barricade around it going be an effective strategy, taking into account their potential counter multifactorial events place under pathology. Besides strong antioxidant properties, naturally occurring reported have neuroprotective effects by modulating Aβ biogenesis pathway disease. Thus, review, I am focusing on unlocking secrets mechanistic advantages fight with AD related

Language: Английский

Citations

48
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions DOI Creative Commons
Ana Tadijan, Ignacija Vlašić, Josipa Vlainić

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 2049 - 2049

Published: Oct. 18, 2022

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic have received growing interest as treatment options in neurodegenerative conditions. various experimental settings, they displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, neuroprotective effects. However, due to numerous targets downstream effectors of their action, cellular molecular mechanisms underlying these effects are rather complex still under discussion. Cannabinoids able neutralize free radicals modulate production reactive oxygen species activity antioxidative systems acting on CB1 CB2 cannabinoid receptors. The activation receptors stimulates signaling pathways involved defense survival (such phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), Nrf2 pathways) regulates glutamatergic signaling, N-methyl-D-aspartate (NMDA) receptors, calcium influx, induction Ca2+-regulated cascades, whereas mediated by suppression microglial release prooxidative proinflammatory mediators. This review summarizes main new advances understanding cannabinoids. Because plethora possible pharmacological interventions related oxidative stress cannabinoid-mediated neuroprotection, future research should be directed towards a better interplay between activated signal transduction with aim improve efficacy targeting endocannabinoid system.

Language: Английский

Citations

42
Cyperus esculentus (tiger nut): An insight into its bioactive compounds, biological activities, nutritional and health benefits DOI Creative Commons
Great Iruoghene Edo, Favour Ogheneoruese Onoharigho, Agatha Ngukuran Jikah

et al.

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100511 - 100511

Published: Nov. 9, 2023

Physiologically important qualities and nutritional benefits prove the value of tiger nut. Phytochemicals like flavonoids, alkaloids, fat, fatty acids etcetera that are abundant throughout plant aid in a number metabolic processes as well elicit therapeutic biological effects anti-oxidation, anti-inflammation, anti-cardiovascular disease, aphrodisiac, anti-diabetic thus improving general wellbeing health conditions. More to that, various other industries than medical (Pharmaceutical, agricultural, food e.t.c), nuts utilizable making starch, animal feed, beverages, biofuel mention but few. Considering all these enormous applications nut, it is intention this review, add scope available information regarding them stating with specificity their bioactive compounds, activities, industrial applications.

Language: Английский

Citations

34
Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders DOI

Rohan Gupta,

Dia Advani, Divya Yadav

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(11), P. 6476 - 6529

Published: July 17, 2023

Language: Английский

Citations

23
Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease DOI Open Access
Hind Muteb Albadrani, Payal Chauhan, Sumel Ashique

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116376 - 116376

Published: March 19, 2024

Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, class naturally occurring compounds, immensely beneficial the treatment or management various disorders illnesses. Naturally sources polyphenols include plants plant-based foods, such as fruits, herbs, tea, vegetables, coffee, red wine, dark chocolate. Polyphenols have unique properties, being source anti-oxidants possessing anti-aging anti-cancerous properties. Currently, dietary become potential therapeutic approach AD, depending on research findings. Dietary can be an effective strategy to tackle multifactorial events that occur AD. For instance, been reported exhibit neuroprotection by modulating Aβ biogenesis pathway Many nanoformulations established enhance bioavailability polyphenols, nanonization most promising. This review comprehensively provides mechanistic insights into neuroprotective treating It also reviews usability polyphenol nanoformulation treatment.

Language: Английский

Citations

16
A review on the biological and bioactive components of Cyperus esculentus L.: insight on food, health and nutrition DOI
Great Iruoghene Edo, Princess Oghenekeno Samuel, Susan Chinedu Nwachukwu

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(14), P. 8414 - 8429

Published: May 20, 2024

Tiger nut (Cyperus esculentus L.) is a small, tuberous root vegetable that has gained increasing attention in recent years due to its potential health benefits. This review article provides an elaborate overview of tiger nut, including botany, historical uses, nutritional composition, benefits and traditional medicinal uses. comprehensively discusses the profile providing detailed understanding nutrient content. Furthermore, are thoroughly reviewed, effects on digestive health, cardiovascular blood sugar control, immune function other therapeutic Scientific articles used for this were retrieved from ScienceDirect, Google Scholar, PubMed SciELO databases. Only published between 1997 2022 research. contributes better prospective uses functional foods medicine by combining available scientific material. © 2024 Society Chemical Industry.

Language: Английский

Citations

14
Psychobiotics and the Microbiota–Gut–Brain Axis: Where Do We Go from Here? DOI Creative Commons
Sylvie Binda, Annie Tremblay, Umar Iqbal

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 634 - 634

Published: March 22, 2024

The bidirectional relationship between the gut microbiota and nervous system is known as microbiota-gut-brain axis (MGBA). MGBA controls complex interactions brain, enteric system, gut-associated immune neuroendocrine systems, regulating key physiological functions such response, sleep, emotions mood, food intake, intestinal functions. Psychobiotics are considered tools with potential to modulate through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects health yet be characterized. This narrative review perspectives article highlights paradigms needing attention scope probiotics applications in human increases, a growing body evidence supporting systemic beneficial effects. However, there limitations overcome before establishing extent which we can incorporate management neuropsychiatric disorders. Although this uses term general manner, it remains important study at strain level most cases.

Language: Английский

Citations

13
Interplay among Oxidative Stress, Autophagy, and the Endocannabinoid System in Neurodegenerative Diseases: Role of the Nrf2- p62/SQSTM1 Pathway and Nutraceutical Activation DOI Creative Commons
Federica Armeli, Beatrice Mengoni, Debra L. Laskin

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 6868 - 6884

Published: July 2, 2024

The onset of neurodegenerative diseases involves a complex interplay pathological mechanisms, including protein aggregation, oxidative stress, and impaired autophagy. This review focuses on the intricate connection between stress autophagy in disorders, highlighting as pivotal disease pathogenesis. Reactive oxygen species (ROS) play dual roles cellular homeostasis regulation, with disruptions redox signaling contributing to neurodegeneration. activation Nrf2 pathway represents critical antioxidant mechanism, while maintains by degrading altered cell components. interaction among p62/SQSTM1, Nrf2, Keap1 forms regulatory essential for response, whose dysregulation leads aggregate accumulation. Targeting Nrf2-p62/SQSTM1 holds promise therapeutic intervention, mitigating preserving functions. Additionally, this explores potential synergy endocannabinoid system neuroprotection. Further research is needed elucidate involved molecular mechanisms develop effective strategies against

Language: Английский

Citations

13
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Marius Turnea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

Citations

8