The Beneficial Effects of Combined Exercise and Polyphenols in Alzheimer's Disease DOI Open Access

Qinghua Tan

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Regular exercise enhances life quality, lowers the risk of cognitive damage, and slows advancement Alzheimer's disease (AD). Natural compounds rich in polyphenols have garnered attention as a non-pharmacological means treating preventing AD. The primary component wine, grape seeds, nuts is polyphenols. Research suggests that slow down rate neurodegeneration AD lessen learning impairment. Furthermore, brain impairments related to cognition. Additionally, can specifically restructure amyloid-β (Aβ) structures soluble oligomers into non-toxic alternative species. They also been revealed increase brain-derived neurotrophic factors expression, suggesting they positive impact on creation neurotrophins. benefits polyphenol supplementation exercise, which both provide neuroprotection, not well studied patients. This review aimed investigate effects combined inflammation, several conformational toxic species Aβ, Aβ-induced apoptosis

Language: Английский

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review DOI Creative Commons
Maroua Jalouli, Md. Ataur Rahman, Partha Biswas

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

Citations

7
Research progress on the regulatory effects of Chinese food and medicine homology on type 1 diabetes mellitus DOI

P H Chen,

Jing Li, Shan Zhang

et al.

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells DOI
He Li,

Changxin Zheng,

Zhenxing Wang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

1
Establishing network pharmacology between natural polyphenols and Alzheimer’s disease using bioinformatic tools – An advancement in Alzheimer’s research DOI Creative Commons
Arunkumar Subramanian,

T. Tamilanban,

Vetriselvan Subramaniyan

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101715 - 101715

Published: Aug. 23, 2024

Alzheimer's disease (AD) is a major cause of disability and one the top causes mortality globally. AD remains public health challenge due to its prevalence, impact on patients caregivers, current lack cure. In recent years, polyphenols have garnered attention for their potential therapeutic effects AD. The objective study was establish network pharmacology between selected plant origin Insilico tools such as SwissADME, ProTox3.0, pkCSM, Swiss Target Prediction, DisGeNET, InterActiVenn, DAVID database, STRING Cytoscape/CytoHubba were employed multi-target polyphenolic compounds. present revealed that out 17 polyphenols, 10 ligands found possess drug-likeness nature along with desirable pharmacokinetic parameters lesser toxicity profile. Also, results highlighted possible interactions targets involved in Further, this has shed light mTOR pathway through autophagic mechanism. Overall, indicated could be better option treating Hence, consumption cocktails part diet produce more effective outcomes against disease. Additional studies are warranted future explore additional pathways genes provide comprehensive understanding regarding usage shortlisted derivatives prevention treatment

Language: Английский

Citations

4
Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders DOI Creative Commons
Neha Kamboj,

S.D. Sharma,

Rahul Kumar

et al.

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Language: Английский

Citations

0
From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine DOI Open Access
Corneliu Toader,

Matei Serban,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

Citations

0
Neuroprotective, and memory enhancement effects of Salvia aristata and its phenolic constituents: an in vitro, and in vivo study DOI Creative Commons
Farid Dabaghian, Mohammad‐Reza Delnavazi, Roshanak Hariri

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 17, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, neuroinflammation, oxidative stress, and memory impairment. The Salvia genus has been used since ancient times for its anti-inflammatory neuroprotective properties. In this study, we aimed to investigate the effects of aristata hydroalcoholic extract (SAHE) dichloromethane (SADE) on various aspects AD. Column chromatography was utilized in phytochemical analysis isolate purify bioactive compounds. structures isolated compounds were determined through spectroscopic techniques, including 1D 2D NMR, along with IR, UV, HRESIMS new compound. Cholinesterase inhibitory activity assessed using modified Ellman's method. Additionally, antioxidant metal chelation capacity SAHE SADE evaluated DPPH assay methods, respectively. Moreover, PC12 cells investigated AlamarBlue assay, ability mitigate scopolamine-induced impairment rats Morris water maze (MWM) test. structurally elucidated an undescribed compound, namely salvinarin (2), as well four known linariin (1), pectolinarin (3), scutellarein 4'-O-methyl-7-O-rutinoside (4), 5-O-coumaroylquinic acid (5) from first time. vitro analyses revealed that SAHE, SADE, exhibited significant against H2O2-induced cytotoxicity cells. Notably, demonstrated potent acetylcholinesterase (AChE) inhibition (IC50 = 322.83 ± 1.11 µg/mL), 99.16 1.24 strong chelating toward Cu2+, Zn2+, Fe2+. oral administration (400 mg/kg/day) significantly ameliorated induced scopolamine rat model. This improvement evident parameters such traveled distance (p < 0.001), escape latency time spent target quadrant 0.01) Considering all findings, neuroprotective, antioxidant, metal-chelating properties, alongside notable efficacy enhancing models, S. could be potential candidate improvement.

Language: Английский

Citations

0
CAN DARK CHOCOLATE IMPROVE OUR COGNITIVE SKILLS? EVALUATING THE IMPACT OF COCOA FLAVANOLS ON FUNCTION OF THE BRAIN – A REVIEW ARTICLE DOI Open Access

Włodzimierz Ługowski,

Julia Samek,

Karolina Bartoszewska

et al.

International Journal of Innovative Technologies in Social Science, Journal Year: 2025, Volume and Issue: 2(46)

Published: May 19, 2025

This review evaluates the impact of cocoa consumption, particularly flavanol-rich dark chocolate, on cognitive function based evidence from 25 human studies. A structured literature search was conducted in PubMed database using predefined keywords, and relevant studies were selected according to methodological quality relevance. Cognitive domains assessed included memory, processing speed, executive function, visual cognition. Findings randomized controlled trials meta-analyses indicate modest benefits, especially long-term memory primarily among middle-aged older adults following chronic flavanol intake. Functional neuroimaging support underlying mechanisms such as enhanced cerebral perfusion, increased neuronal efficiency, modulation hippocampal function. Short-term improvements observed episodic spatial reaction time, sensitivity. However, results across are inconsistent. Large-scale trials, notably COSMOS project, reported no significant benefits daily supplementation general population, though limited noted individuals with poor dietary quality. Some null or adverse outcomes, younger when combined omega-3 fatty acids. In conclusion, intake may confer specific populations contexts. variation study design, dosing, baseline characteristics limits generalizability. Further research is warranted establish optimal regimens, identify responsive subgroups, determine safety.

Language: Английский

Citations

0
Exploring complexities of Alzheimer’s disease: New insights into molecular and cellular mechanisms of neurodegeneration and targeted therapeutic interventions DOI
Abdulmajeed G. Almutary, M. Yasmin Begum,

Ashish Kumar Kyada

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102548 - 102548

Published: Oct. 16, 2024

Language: Английский

Citations

3