Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade

Journal of Tropical Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20

Published: March 11, 2022

The ethnopharmacological information gathered over many centuries and the presence of diverse metabolites have made medicinal plants as prime source drugs. Despite positive attributes natural products, there are questions pertaining to their mechanism actions molecular targets that impede development therapeutic agents. One major challenges in cancer research is toxicity exerted by investigational agents towards host. An understanding targets, underlying mechanisms can reveal anticancer efficacy, help optimal dose selection, mitigate side effects purpose this review collate details on products recently been investigated extensively past decade for potential. Besides, critical analysis multiple cell lines, an in-depth probe toxicological screening rodent models outlined well observe prevalence This provide valuable insights researchers developing methods, strategies during preclinical clinical evaluation candidates.

Language: Английский

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Variation in Phytochemical, Antioxidant and Volatile Composition of Pomelo Fruit (Citrus grandis (L.) Osbeck) during Seasonal Growth and Development

Plants, Journal Year: 2021, Volume and Issue: 10(9), P. 1941 - 1941

Published: Sept. 17, 2021

Citrus fruits exhibit a high level of different phytoconstituents, which the changes in parts fruit during ripening have not been thoroughly studied yet. Thus, this study, we investigated how pomelo (Citrus grandis L.) are modified throughout development two consecutive growing seasons. In detail, main phytochemical compounds, such as total phenolic content, flavonoid antioxidant capacity, DPPH free radical scavenging activity, Ferric reducing power (FRAP), and naringin tannin were analyzed. A systematic metabolism these compounds was found fruit, but some tissues showed fluctuating trend, suggesting dependence on season. Focusing tissue distribution membrane contained highest content; flavedo displayed capacities FRAP activities, whereas maximum accumulation noticed albedo. Instead, activity contents juice. Regarding possible bias pattern for those has development. From GC-MS analysis, 111 identified, where 91 common both Overall, results could be useful food processing industry guidelines excellent quality foods introducing health-beneficial products components into our daily diets.

Language: Английский

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Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves of Olea europaea as Antioxidants, Anti-Infectives and Anticancer Agents on Healthy Growth

Molecules, Journal Year: 2022, Volume and Issue: 27(7), P. 2341 - 2341

Published: April 5, 2022

There is currently a worldwide consensus and recognition of the undoubted health benefits so-called Mediterranean diet, with its intake being associated lower risk mortality. The most important characteristics this type diet are based on consumption significant amounts fruit, vegetables, legumes, nuts, which provide, in addition to some active ingredients, fiber proportion vegetable protein, together extra virgin olive oil (EVOO) as main sources fat. Fish meat from poultry other small farm animals protein. One components, already mentioned, EVOO, rich monounsaturated fatty acids lesser extent polyunsaturated acids. nutrient also provides an set phytochemicals whose potential widely spread agreed upon. These include anthocyanins, stilbenes, flavonoids, phenolic acids, terpenes varying complexities. Therefore, inclusion molecules, proven healthy effect, unquestionable preventive and/or curative activity group pathologies related cardiovascular, infectious, cancerous diseases, well those metabolic syndrome. aim review therefore shed light nutraceutical role two present Olea europaea fruit leaf extracts, polyphenols, triterpenes, animal growth. Their immunomodulatory, anti-infective, antioxidant, anti-aging, anti-carcinogenic capabilities show them be nutraceuticals, providing

Language: Английский

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Physiological and Qualitative Response of Cucurbita pepo L. to Salicylic Acid under Controlled Water Stress Conditions

Horticulturae, Journal Year: 2022, Volume and Issue: 8(1), P. 79 - 79

Published: Jan. 14, 2022

Limited water stress is one of the most important environmental stresses that affect growth, quantity and quality agronomic crops. This study was undertaken to investigate effect foliar applied salicylic acid (SA) on physiological responses, antioxidant enzymes qualitative traits Cucurbita pepo L. Plants exposed water-stressed conditions in two years field studies. Irrigation regimes at three soil matric potential levels (−0.3, −1.2 −1.8 MPa) SA four (0.0, 0.5, 1.0 1.5 mg/L) were considered as main plot sub-plots, respectively. The values (MPa) measured just before irrigation. Results showed under stressed alone, amounts malondialdehyde (MDA), hydrogen peroxide (H2O2) ion leakage higher compared with control treatment. However, spraying both non-stress reduced above parameters. Water increased CAT, APX GR activity. However application led decrease all levels. amount carbohydrates fatty acids intensity modulated this response. By increasing concentration optimum conditions, saturated content decreased. According our data, an effective approach improve pumpkin growth conditions.

Language: Английский

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Secondary Metabolites Isolated from Artemisia afra and Artemisia annua and Their Anti-Malarial, Anti-Inflammatory and Immunomodulating Properties—Pharmacokinetics and Pharmacodynamics: A Review

Metabolites, Journal Year: 2023, Volume and Issue: 13(5), P. 613 - 613

Published: April 29, 2023

There are over 500 species of the genus Artemisia in Asteraceae family distributed globe, with varying potentials to treat different ailments. Following isolation artemisinin (a potent anti-malarial compound a sesquiterpene backbone) from annua, phytochemical composition this has been interest recent decades. Additionally, number investigations other species, including those afra search for new molecules pharmacological potentials, increased years. This led several compounds both majority monoterpenes, sesquiterpenes, and polyphenols activities. review aims discuss most important present plant properties, anti-inflammatory immunomodulating an emphasis on their pharmacokinetics pharmacodynamics properties. toxicity plants anti-malaria Artemisia, is discussed. As such, data were collected via thorough literature web databases, such as ResearchGate, ScienceDirect, Google scholar, PubMed, Phytochemical Ethnobotanical up 2022. A distinction was made between involved direct anti-plasmodial activity expressing activities or anti-fever For activities, influencing bioavailability (CYP effect P-Glycoprotein effect) affecting stability pharmacodynamic active components.

Language: Английский

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Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 27, 2024

Abstract The development of innovative wound dressing materials is crucial for effective care. It’s an active area research driven by a better understanding chronic pathogenesis. Addressing care properly clinical challenge, but there growing demand advancements in this field. synergy medicinal plants and nanotechnology offers promising approach to expedite the healing process both acute wounds facilitating appropriate progression through various phases. Metal nanoparticles play increasingly pivotal role promoting efficient preventing secondary bacterial infections. Their small size high surface facilitate enhanced biological interaction penetration at site. Specifically designed topical drug delivery, these enable sustained release therapeutic molecules, such as growth factors antibiotics. This targeted ensures optimal cell-to-cell interactions, proliferation, vascularization, fostering controlled healing. Nanoscale scaffolds have significant attention due their attractive properties, including delivery capacity, porosity area. They mimic Extracellular matrix (ECM) hence biocompatible. In response alarming rise antibiotic-resistant, biohybrid nanofibrous dressings are gradually replacing conventional antibiotic systems. emerging class comprises biopolymeric nanofibers with inherent antibacterial nature-derived compounds, biofunctional agents. Nanotechnology, diminutive nanomaterials, nanoscaffolds, nanofibers, biomaterials harnessed aimed review article discusses effects loaded on healing, (in vivo vitro) mechanical outcomes. Graphical

Language: Английский

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Phosphorus Fertilizer and Arbuscular Mycorrhizal Fungi Application Improves Bitter Melon Fruit Yield and Some Phytochemical Compounds under Irrigation Deficit Stress

Current Plant Biology, Journal Year: 2025, Volume and Issue: unknown, P. 100446 - 100446

Published: Jan. 1, 2025

Language: Английский

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Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus

Journal of Chemistry, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 10

Published: Oct. 31, 2021

Medicinal plants play a fundamental part in health sectors via the management of different infectious diseases because their wide plenitude wellspring bioactive phytochemicals. Research activities on them have got attention throughout world present days search low-cost and safe compounds for diabetes. This is literature-based analysis alkaloids from medicinal preventive or treatment approaches to The most abundant diversified group secondary metabolites, i.e., alkaloids, show antidiabetic activity through inhibition enzymes (α-amylase, α-glucosidase, aldose reductase, dipeptidyl peptidase-IV, protein tyrosine phosphatase-1B); advanced glycation end products; increment insulin secretion its sensitivity; enhancement glucose uptake; antioxidant ability. study useful examination dynamic advancement new medication mankind.

Language: Английский

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Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6114 - 6114

Published: Sept. 19, 2022

This work assessed the phenolic and flavonoid components their antioxidant, antifungal, antibacterial effects in ethanolic extract of barberry leaf roots. The antibactericidal activity root extracts against pathogenic bacteria was tested using agar diffusion microdilution broth production for lowest inhibitory concentration (MIC). Berberis vulgaris inhibited Staphylococcus aureus ATCC9973, Escherichia coli HB101, enteritis, Cip812. disc assay technique used to assess bactericidal versus both Gram-positive Gram-negative strains. Hydro alcoholic more effective bacterial than fungal results showed that roots had similar antifungal activities. mycelial growth Penicillium verrucosum, Fusarium proliferatum, Aspergillus ochraceous, niger, flavus. has excellent antibacterial, effects. exhibited antimicrobial vitro, MIC parts efficiently affected pathogens vitro. In conclusion, leaves have considerable can be as a source bioactive compounds benefit human health.

Language: Английский

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The Role of Natural and Semi-Synthetic Compounds in Ovarian Cancer: Updates on Mechanisms of Action, Current Trends and Perspectives

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2070 - 2070

Published: Feb. 22, 2023

Ovarian cancer represents a major health concern for the female population: there is no obvious cause, it frequently misdiagnosed, and characterized by poor prognosis. Additionally, patients are inclined to recurrences because of metastasis treatment tolerance. Combining innovative therapeutic techniques with established approaches can aid in improving outcomes. Because their multi-target actions, long application history, widespread availability, natural compounds have particular advantages this connection. Thus, effective alternatives improved patient tolerance hopefully be identified within world nature-derived products. Moreover, generally perceived more limited adverse effects on healthy cells or tissues, suggesting potential role as valid alternatives. In general, anticancer mechanisms such molecules connected reduction cell proliferation metastasis, autophagy stimulation response chemotherapeutics. This review aims at discussing mechanistic insights possible targets against ovarian cancer, from perspective medicinal chemists. addition, an overview pharmacology products studied date towards models presented. The chemical aspects well available bioactivity data discussed commented on, attention underlying molecular mechanism(s).

Language: Английский

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