eXPRESS Polymer Letters,
Journal Year:
2023,
Volume and Issue:
18(2), P. 160 - 192
Published: Dec. 6, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
a
remarkable
capacity
to
absorb
substantial
amounts
of
water
and
biological
fluids,
rendering
them
highly
attractive
for
drug
delivery
applications.The
COVID-19
pandemic
has
acted
as
catalyst
research
innovation
in
the
realm
polymer-based
delivery,
particular
emphasis
on
antiviral
therapeutics,
vaccines,
diagnostics,
precision
respiratory
system.The
distinctive
attributes
hydrogels,
such
their
biocompatibility,
customizable
release
profiles,
ease
functionalization,
establish
versatile
platforms
development
advanced
systems
combat
not
only
but
also
spectrum
other
infectious
diseases.This
study
is
dedicated
scruti-nizing
evaluating
characteristics
employed
treatment
diseases
associated
SARS-CoV-2
virus.Furthermore,
investigation
introduces
novel
classification
system
deployed
SARS-CoV-2-related
diseases.Additionally,
paper
provides
an
up-to-date
evaluation
latest
developed
utilized
dis-eases
linked
virus,
based
conducted
through
recent
months
2023.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 523 - 523
Published: June 27, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
crosslinks
widely
applied
for
drug
delivery
applications
because
of
their
ability
to
hold
large
amounts
water
and
biological
fluids
control
release
based
on
unique
physicochemical
properties
biocompatibility.
Current
trends
in
the
development
hydrogel
systems
involve
drugs
response
specific
triggers
such
as
pH,
temperature,
or
enzymes
targeted
reduce
potential
systemic
toxicity.
In
addition,
developing
injectable
formulations
that
easily
used
sustain
during
this
extended
time
is
a
growing
interest.
Another
emerging
trend
synthesis
nano
other
functional
substances
improving
loading
efficacy.
Following
these
trends,
advanced
possessing
mechanically
improved
properties,
controlled
rates,
biocompatibility
focus
field.
More
complex
multi-drug
combination
therapies
will
be
developed
advancements.
polymer-based
gaining
increasing
attention
personalized
medicine
tailored
patient,
example,
combinations,
target-specific
delivery,
improvement
disease
treatment
effectiveness,
healthcare
cost
reduction.
Overall,
application
advancing
rapidly,
towards
more
efficient
effective
future.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 30, 2025
Gynecological
cancers,
including
cervical,
ovarian,
and
endometrial
malignancies,
remain
a
significant
global
health
burden,
exacerbated
by
disparities
in
access
to
preventive
measures
such
as
HPV
vaccination
routine
screening.
The
cGAS/STING
signaling
pathway,
pivotal
mechanism
innate
immunity,
detects
cytosolic
DNA
from
pathogens
or
cellular
damage,
triggering
immune
responses
via
type
I
interferons
inflammatory
cytokines.
This
pathway’s
dual
role
gynecological
either
promoting
antitumor
immunity
facilitating
tumor
evasion,
makes
it
compelling
target
for
innovative
therapies.
article
outlines
cGAS/STING’s
influence
on
microenvironments,
surveillance,
inflammation,
with
emphasis
molecular
mechanisms
driving
cancer
progression.
It
explores
interactions
between
damage
response
pathways
modulation,
highlighting
the
impact
of
activation
suppression
cancers.
therapeutic
potential
STING
agonists,
PARP
inhibitors,
targeted
immunotherapies
is
reviewed,
demonstrating
how
these
approaches
can
boost
responses,
counteract
chemotherapy
resistance,
improve
patient
outcomes.
study
also
discusses
strategies
leveraging
enhance
efficacy
address
tumor-mediated
suppression,
providing
insights
into
future
directions
personalized
treatments.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5082 - 5082
Published: June 29, 2023
Ovarian
cancer
(OC)
is
one
of
the
most
common
types
in
women
with
a
high
mortality
rate,
and
treatment
OC
prone
to
recurrence
rates
side
effects.
Scutellaria
baicalensis
(SB)
herbal
medicine
good
anti-cancer
activity,
several
studies
have
shown
that
SB
its
flavonoids
some
anti-OC
properties.
This
paper
elucidated
pathogenesis
OC,
including
cell
proliferation
cycle
regulation,
invasion
metastasis,
apoptosis
autophagy,
drug
resistance
angiogenesis.
The
mechanisms
flavonoids,
wogonin,
baicalein,
baicalin,
Oroxylin
A,
scutellarein,
are
revealed,
such
as
wogonin
inhibits
proliferation,
induces
apoptosis,
increases
cytotoxicity
drug.
Baicalein
also
vascular
endothelial
growth
factor
(VEGF)
expression
etc.
Analyzing
their
advantages
disadvantages
treating
provides
new
perspective
on
role
treatment.
It
serves
resource
for
future
research
development.
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
52(6)
Published: Oct. 15, 2024
Renal
cell
carcinoma
(RCC)
is
distinguished
by
its
varied
metabolic
reprogramming
driven
tumor
suppressor
gene
dysregulation
and
oncogene
activation.
Tumors
can
adapt
nutrient
uptake
metabolism
pathways
to
meet
the
altered
biosynthetic,
bioenergetic
redox
demands
of
cancer
cells,
whereas
conventional
chemotherapeutics
molecular
inhibitors
predominantly
target
individual
without
addressing
this
adaptability.
Flavonoids,
which
are
well‑known
for
their
antioxidant
anti‑inflammatory
properties,
offer
a
unique
approach
influencing
multiple
targets.
The
present
comprehensive
review
reveals
intricate
processes
RCC
reprogramming,
encompassing
glycolysis,
mitochondrial
oxidative
phosphorylation
fatty
acid
biosynthesis.
insights
derived
from
may
contribute
understanding
specific
anticancer
mechanisms
flavonoids,
potentially
paving
way
development
natural
antitumor
drugs
focused
on
RCC.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
Osbeckia
parvifolia
,
an
endemic
edible
plant
of
Western
Ghats,
was
investigated
in
the
present
study
for
its
polyphenolic
compounds,
including
content,
constituents,
extraction
through
ultrasonic‐assisted
maceration
technique
and
therapeutic
potential
biomedical
applications.
The
methanolic
extract
(OPM)
exhibited
IC
50
value
1.25
μg/mL
against
2,2‐Diphenyl‐1‐picrylhydrazyl
(DPPH)
radicals.
Furthermore,
ethyl
acetate
extracts
also
strongly
inhibited
5‐lipoxygenase,
especially
OPM
(84.93
%),
which
comparable
to
standard
curcumin.
elicited
cytotoxicity
SKOV3
ovarian
cancer
cells
(93.80
surpassing
paclitaxel.
Bio‐accessibility
analysis
demonstrated
that
release
phenolic
compounds
antioxidant
were
very
high
(above
100
revealing
possibility
synergistic
efficacy
complexes
drug
development.
Gas
Chromatography
‐Mass
Spectrometry
(GC‐MS)
revealed
22
bioactive
OPM,
such
as
epicatechin,
quercetin,
psoralidin.
This
confirmed
by
High
Performance
Liquid
(HPLC)
High‐Pressure
Thin
Layer
(HPTLC)
analyses,
a
quantity
catechin
(37.45
mg/g).
Molecular
docking
significant
binding
affinity
these
proteins
oncoproteins
PI3K
(−8.52
kcal/mol)
Casp‐8
(−8.41
kcal/mol).
Adsorption,
Distribution,
Metabolism,
Excretion
Toxicity
(ADMET)
profiling
indicated
favorable
pharmacokinetic
properties
supporting
their
candidacy
formulations
cancer.
