Hepatoprotective, Antioxidant and Anti-inflammatory Actions of a Novel 5-Thiocyanauracil Compound and Ascorbic Acid against Paracetamol-Induced Hepatotoxicity in Female Rats DOI Open Access

Ibtihal Naoor,

Nadheerah F. Neamah,

J.A.K. Hasan

et al.

Journal of Pharmaceutical Negative Results, Journal Year: 2022, Volume and Issue: 13(SO3)

Published: Jan. 1, 2022

The 5-Thiocyanauracil (TCU) is a novel synthetic molecule that has been proposed for its hepatoprotective, antioxidant, and antiinflammatory action.Overdosing on paracetamol linked to hepatic damage, which major health danger, especially women.Our research's objective was determine the induced hepatic, anti-inflammatory, coagulopathy effects of against liver damage caused by in rats.Using fifty female rats (10 each group), following treatments were administered groups: Control (D.W or C) group, Paracetamol PA (500 mg/kg/day) TCU (50 mg/kg/day), & Ascorbic Acid (AA) (AA 50 PA+TCU group.For 25 days, given orally.Rats' hearts directly used draw blood samples.Prothrombin Time (PT) evaluated using an auto-analyzer (Huma Clot Jonior), whereas protein carboxylase (PC), Glutathione peroxidase (GPX), interleukin 6 (IL-6) detected serum homogenate ELISA method.TCU treatment dramatically increased GPX activity, decreased IL6 PC levels as compared PA.This finding supports ability reduce PT/INR trend undergo inhibit oxidation, inflammatory progressions over dosage.In conclusion, influenced potential hepatoprotective action could have partially attributed anti-inflammatory antioxidant properties addition tests PA-induced acute injury rat model.

Language: Английский

Lipid Peroxidation and Antioxidant Protection DOI Creative Commons
Luca Valgimigli

Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1291 - 1291

Published: Aug. 24, 2023

Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and role secondary other biomolecules, such as proteins. The chemistry LP consequences are reviewed focus on kinetics various processes, which helps understand mechanisms efficacy antioxidant strategies. main types antioxidants discussed terms structure–activity rationalization, mechanism kinetics, well their potential modulating ferroptosis. Phenols, pyri(mi)dinols, based heavy chalcogens (Se Te), diarylamines, ascorbate others addressed, along latest unconventional strategies double-sided superoxide/hydroperoxyl radical system.

Language: Английский

Citations

89
The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae DOI Creative Commons
Lavinia-Lorena Pruteanu, David Bailey, A. C. Grădinaru

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 860 - 860

Published: April 2, 2023

It is more effective to maintain good health than regain it after losing it. This work focuses on the biochemical defense mechanisms against free radicals and their role in building maintaining antioxidant shields, aiming show how balance, as much possible, situations which we are exposed radicals. To achieve this aim, foods, fruits, marine algae with a high content should constitute basis of nutritional elements, since natural products known have significantly greater assimilation efficiency. review also gives perspective use antioxidants can extend life food products, by protecting them from damage caused oxidation well additives.

Language: Английский

Citations

58
Green synthesis, characterization, antimicrobial activity, and optimization of iron oxide nanoparticles for efficient Acid Red 73 dye removal from aqueous solution by a Taguchi approach DOI

Ahmed E. Alprol,

Mohamed A. El‐Sheikh, Paulo Pereira

et al.

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

Citations

1
Sulphur-mediated plant resistance elicits phenolic defense in canola to reduce aphid reproduction and improve crop yield in canola DOI
Muhammad Wajid Javed, Dilbar Hussain, M. Zubair

et al.

Archives of Phytopathology and Plant Protection, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 28, 2025

Language: Английский

Citations

1
Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis DOI Creative Commons
Anqi Ge, Qi He, Zhao Da

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 28(1)

Published: Dec. 22, 2023

Abstract Breast cancer is the most prevalent worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due clinical heterogeneity of breast cancer, majority patients develop drug resistance metastasis following treatment. Ferroptosis, form programmed cell death dependent on iron, characterized by accumulation lipid peroxides, elevated levels iron ions peroxidation. The underlying mechanisms signalling pathways associated ferroptosis are intricate interconnected, involving various proteins enzymes such as cystine/glutamate antiporter, glutathione peroxidase 4, inhibitor 1 dihydroorotate dehydrogenase. Consequently, emerging research suggests that may offer novel target for treatment; however, in urgently require resolution. Additionally, certain natural compounds have been reported induce ferroptosis, thereby interfering cancer. Therefore, this review not only discusses molecular multiple mediate (including metastasis, invasion proliferation) but also elaborates which Furthermore, summarizes potential compound types serve inducers future tumour cells, providing lead development ferroptosis‐inducing agents. Last, proposes synergy combining traditional drugs treatment suggesting directions offering new insights.

Language: Английский

Citations

13
Sulfated phenolic polymers as non-toxic antifouling agents DOI Creative Commons
Maria Laura Alfieri, Catarina Gonçalves, Joana R. Almeida

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112855 - 112855

Published: Feb. 13, 2024

Nature-inspired highly sulfated bioactive polyphenols are recently emerging as antifouling agents with low or non-toxic effects to the environment representing a valuable alternative most used harmful biocides. In this frame, we report herein preparation of derivatives two phenolic polymers tyrosol and gallic acid previously obtained via convenient horseradish peroxidase/H2O2-catalyzed oxidation process. A mild sulfation procedure based on use sulfur trioxide triethylamine complex under microwave irradiation afforded corresponding OligoTyrS OligoGallS in good yields (90–95 % w/w). Elemental analysis, FT-IR MALDI-MS investigation provided evidence for an almost complete –OH groups. line high degree sulfation, exhibited lower antioxidant properties compared non-sulfated evaluated by 2,2-diphenyl-1-picrylhydrazyl ferric reducing/antioxidant power assays. contrast polymer, showed significant inhibitory effect against settlement mussel (Mytilus galloprovincialis) plantigrade without lethality affecting selected biofilm-forming organisms like five marine bacteria diatom. Both were also found be non-target species Artemia salina. The overall results presented put forward potential non-natural new agents.

Language: Английский

Citations

4
Synthesis, molecular docking, assessment of biological and anti-diabetic properties of benzalacetophenone derivatives DOI Creative Commons
Wesam S. Shehab,

Nourhan Kh. R. Elhoseni,

Wael M. Aboulthana

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Language: Английский

Citations

0
Synthesis and Antioxidant Activity of New Catechol Thioethers with the Methylene Linker DOI Creative Commons
Ivan V. Smolyaninov, Daria A. Burmistrova, Maxim V. Arsenyev

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(10), P. 3169 - 3169

Published: May 16, 2022

Novel catechol thio-ethers with different heterocyclic substituents at sulfur atom were prepared by reacting 3,5-di-tert-butyl-6-methoxymethylcatechol functionalized thiols under acidic conditions. A common feature of compounds is a methylene bridge between the ring and thioether group. Two catechols thio-ether group, bound directly to ring, also considered assess effect linker on antioxidant properties. The crystal structures benzo-thiazole moieties established single-crystal X-ray analysis. radical scavenging activities determined using 2,2'-diphenyl-1-picrylhydrazyl test, ABTS∙+, CUPRAC (TEAC) assays, reaction superoxide anion generated xanthine oxidase (NBT assay), oxidative damage DNA, process lipid peroxidation rat liver (Wistar) homogenates in vitro. Most catechol-thioethers exhibit effect, which varies from mild moderate depending model system. dual anti/prooxidant activity characterizes adamantyl or thio-phenol substituent atom. Catechol containing groups (thiazole, thiazoline, benzo-thiazole, benzo-xazole) can be effective antioxidants cytoprotective These protect molecules DNA lipids species.

Language: Английский

Citations

17
Organic selenocompounds: are they the panacea for human illnesses? DOI
Pablo A. Nogara, Meire Ellen Pereira, Cláudia S. Oliveira

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(21), P. 9959 - 9988

Published: Jan. 1, 2023

The pharmacological studies of organoselenium compounds need to be profoundly improved find an actual application this interesting class molecules.

Language: Английский

Citations

10
Research Progress on the Mechanism of the Impact of Myofibrillar Protein Oxidation on the Flavor of Meat Products DOI Creative Commons
Lingping Zhang,

Dongsong Yang,

Ruiming Luo

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(20), P. 3268 - 3268

Published: Oct. 15, 2024

Myofibrillar proteins primarily consist of myosin, actin, myogenin, and actomyosin. These form complex networks within muscle fibers are crucial to the physical chemical properties meat. Additionally, myofibrillar serve as significant substrates for adsorption volatile flavor compounds, including aldehydes, alcohols, ketones, sulfur nitrogen which contribute overall profile meat products. A series reactions occur during processing, storage, transportation Oxidation is one most reactions. Oxidative modification can alter proteins, ultimately impacting sensory quality products, flavor, taste, color. In recent years, considerable attention has been focused on effects protein oxidation its regulation. This study investigates impact attributes products by analyzing processes factors that initiate oxidation. it explores control implications providing theoretical insights relevant processing methods procedures.

Language: Английский

Citations

3