Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115571 - 115571
Published: Sept. 25, 2023
Colorectal
cancer
is
a
prevalent
malignant
tumor
with
complex
and
diverse
pathogenesis.
In
recent
years,
natural
products
have
shown
promising
application
prospects
as
sources
of
anticancer
drugs.
BBR,
class
benzoquinoline
alkaloids
extracted
from
various
plants,
widely
used
in
disease
treatments
owing
to
its
pharmacological
activities,
including
antibacterial,
anti-inflammatory,
antioxidant,
anticancer,
anti-angiogenesis
properties.
Research
has
demonstrated
that
BBR
exerts
an
anti-Salmonella
-Escherichia
coli
infection
effect,
attenuating
inflammatory
reactions
by
inhibiting
harmful
bacteria.
During
the
stage
colorectal
precancerous
lesions,
inhibits
activity
cell
cyclin
regulating
PI3K/AKT,
MAPK,
Wnt
signaling
pathways,
thereby
decelerating
cycle
progression
polyp
or
adenoma
cells.
Moreover,
inhibitory
effect
on
primarily
occurs
through
regulation
cycle,
anti-angiogenesis,
gut
microbiota,
antioxidant
pathways.
The
specific
involved
pathways
include
MPK/ERK,
NF-kB,
EGFR
encompassing
Bcl-2
family
proteins,
vascular
endothelial
growth
factor,
superoxide
dismutase.
This
study
reviews
summarizes,
for
first
time,
mechanisms
action
carcinogenesis
process
cancer,
providing
novel
insights
clinical
intestinal
diseases.
Poultry Science,
Journal Year:
2024,
Volume and Issue:
103(8), P. 103968 - 103968
Published: June 11, 2024
Berberine
(BBR),
a
well-known
quaternary
ammonium
alkaloid,
is
recognized
for
its
ability
to
prevent
and
alleviate
metabolic
disorders
because
of
anti-oxidative
anti-inflammatory
properties.
However,
the
underlying
mechanisms
BBR
mitigate
fatty
liver
hemorrhagic
syndrome
(FLHS)
through
modulation
gut
microbiota
their
metabolism
remained
unclear.
The
results
revealed
that
ameliorates
lipid
disorder
in
high-energy
low-protein
(HELP)
diet-induced
FLHS
laying
hens,
as
evidenced
by
improved
function
deposition
liver,
reduced
blood
lipids,
expression
synthesis-related
factors.
Moreover,
alleviated
HELP
barrier
dysfunction,
increased
microbial
population,
dysregulated
ileum.
reshaped
HELP-perturbed
microbiota,
particularly
declining
abundance
Desulfovibrio_piger
elevating
Bacteroides_salanitronis_DSM_18170.
Meanwhile,
metabolomic
profiling
analysis
function,
reducing
levels
hydrocinnamic
acid,
dehydroanonaine,
leucinic
acid.
Furthermore,
fecal
transplantation
(FMT)
experiments
BBR-enriched
hepatic
intestinal
inflammation
compared
with
those
chicks
received
HELP.
Collectively,
our
study
provided
evidence
effectively
induced
reshaping
homeostasis
within
liver-gut
axis.
PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e17094 - e17094
Published: March 29, 2024
Liver
disease
is
a
common
and
serious
threat
to
human
health.
The
progression
of
liver
diseases
influenced
by
many
physiologic
processes,
including
oxidative
stress,
inflammation,
bile
acid
metabolism,
autophagy.
Various
factors
lead
the
dysfunction
these
processes
basing
on
different
pathogeny,
pathology,
clinical
manifestation,
pathogenesis,
are
grouped
into
categories.
Specifically,
Sirtuin1
(SIRT1),
member
sirtuin
protein
family,
has
been
extensively
studied
in
context
injury
recent
years
confirmed
significant
role
disease.
SIRT1
found
play
critical
regulating
key
injury.
Further,
seems
cause
divers
outcomes
types
diseases.
Recent
studies
have
showed
some
therapeutic
strategies
involving
modulating
SIRT1,
which
may
bring
novel
target.
To
elucidate
mechanisms
underlying
sirtuin1
its
potentiality
as
target,
this
review
outlines
signaling
pathways
associated
with
injury,
discusses
advances
targeting
Acta Histochemica,
Journal Year:
2024,
Volume and Issue:
126(1), P. 152134 - 152134
Published: Jan. 1, 2024
Endoplasmic
reticulum
(ER)
stress
plays
a
key
role
in
the
pathogenesis
of
several
organ
damages.
Studies
show
that
excessive
ER
(ERS)
can
destroy
cellular
homeostasis,
causing
cell
damage
and
physiological
dysfunction
various
organs.
In
recent
years,
Sirtuin1
(SIRT1)
has
become
research
hotspot
on
ERS.
Increasing
evidence
suggests
SIRT1
positive
ERS-induced
via
multiple
mechanisms,
including
inhibiting
apoptosis
promoting
autophagy.
also
alleviate
liver,
heart,
lung,
kidney,
intestinal
by
We
discuss
possible
mechanism
SIRT1,
explore
potential
therapeutic
targets
diseases,
provide
theoretical
basis
for
treating
ERS-related
diseases.
Biochemistry and Biophysics Reports,
Journal Year:
2023,
Volume and Issue:
34, P. 101476 - 101476
Published: April 25, 2023
Nicotinamide
adenine
dinucleotide
(NAD+)
-dependent
protein
deacetylase
SIRT1
plays
an
important
role
in
the
regulation
of
metabolism.
Although
administration
nicotinamide
mononucleotide
(NMN),
a
key
NAD+
intermediate,
has
been
shown
to
ameliorate
metabolic
disorders,
such
as
insulin
resistance
and
glucose
intolerance,
direct
effect
NMN
on
lipid
metabolism
adipocytes
remains
unclear.
We
here
investigated
storage
3T3-L1
differentiated
adipocytes.
Oil-red
O
staining
showed
that
treatment
reduced
accumulation
these
cells.
was
found
enhance
lipolysis
since
concentration
glycerol
media
increased
by
treatment.
Western
blotting
real-time
RT-PCR
analysis
revealed
adipose
triglyceride
lipase
(ATGL)
expression
at
both
mRNA
level
with
Whereas
AMPK
activation,
inhibitor
compound
C
restored
NMN-dependent
upregulation
ATGL
cells,
suggesting
upregulates
through
SIRT1-AMPK
axis.
significantly
decreased
subcutaneous
fat
mass
mice
high-fat
diet.
also
adipocyte
size
Consistent
alteration
size,
slightly,
albeit
significantly,
These
results
indicate
suppresses
diet-induced
obese
mice,
potentially
part
via
ATGL.
Unexpectedly,
reduction
well
were
not
observed
epididymal
fat,
implying
effects
are
site-specific
tissue.
Thus,
findings
provide
insights
into
mechanism
NMN/NAD+
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7725 - 7725
Published: Nov. 23, 2023
Demethyleneberberine
is
an
active
component
extracted
from
the
Chinese
herbal
drug
Cortex
Phellodendri.
It
also
a
metabolite
of
berberine
in
animals
and
humans.
However,
pharmacokinetics,
tissue
distribution
excretion
demethyleneberberine
have
not
been
reported.
The
present
study
aimed
to
investigate
pharmacokinetic
parameters
by
applying
high-performance
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS).
After
intragastric
administration
rats
mice,
were
comparatively
studied
for
first
time.
plasma
concentration
reached
its
peak
within
5
min
after
both
mice.
Furthermore,
bioavailability
was
comparable,
ranging
4.47%
5.94%,
higher
than
that
berberine.
total
urine,
feces
bile
7.28~9.77%.
These
findings
provide
valuable
insights
into
pharmacological
clinical
research
on
demethyleneberberine.
Journal of Food Biochemistry,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 13
Published: Jan. 18, 2024
Since
chronic
alcoholic
liver
disease
(ALD)
is
a
significant
global
health
concern,
several
studies
have
shown
that
chitooligosaccharides
(COS)
exhibit
hepatoprotective
effects.
This
paper
examined
the
COS
protective
effect
on
ALD
mice.
Results
showed
improved
lipid
accumulation,
injury,
and
oxidative
stress
levels
in
mice
while
inhibiting
cytochrome
P450
protein
2E1
(CYP2E1)
expression
promoting
alcohol
dehydrogenase
(ADH)
acetaldehyde
(ALDH1)
expression,
indicating
could
ameliorate
metabolism.
Moreover,
intervention
also
enhanced
antioxidant
capacity
of
upregulated
peroxisome
proliferator-activated
receptor
gamma
coactivator
1α
(PGC-1),
silent
information
regulator
1
(SIRT1),
HO-1,
nuclear
factor-erythroid
2-related
factor
2
(NRF2)
levels.
In
addition,
increased
α
(PPARα),
acyl-CoA
oxidase
(ACOX),
synthetase
long-chain
family
member
(ACSL),
carnitine
palmitoyltransferase
1A
(CPT-1A),
(CPT2)
by
upregulating
fatty
acid
β
oxidation
pathway
restoring
mitochondrial
genesis.
From
liver-gut
axis
perspective,
intestinal
barrier
function
increasing
adhesion
junction
(AJ)
tight
(TJ)
expression.
Therefore,
displayed
ability
against
ALD.
The
results
provide
theoretical
basis
for
utilizing
supplemental
dietary
as
functional
food
alternative
treating
