Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle‐based therapeutic strategies for the management and treatment of diabetic foot ulcers

Cell Biochemistry and Function, Journal Year: 2023, Volume and Issue: 41(5), P. 517 - 541

Published: June 6, 2023

Abstract Hyperglycemia, a distinguishing feature of diabetes mellitus that might cause diabetic foot ulcer (DFU), is an endocrine disorder affects extremely high percentage people. Having comprehensive understanding the molecular mechanisms underlying pathophysiology wound healing can help researchers and developers design effective therapeutic strategies to treat process in patients. Using nanoscaffolds nanotherapeutics with dimensions ranging from 1 100 nm represents state‐of‐the‐art viable strategy for accelerating patients, particularly those DFU. Nanoparticles interact biological constituents infiltrate sites owing their reduced diameter enhanced surface area. Furthermore, it noteworthy they promote processes vascularization, cellular proliferation, cell signaling, cell‐to‐cell interactions, formation biomolecules are essential healing. Nanomaterials possess ability effectively transport deliver various pharmacological agents, such as nucleic acids, growth factors, antioxidants, antibiotics, specific tissues, where be continuously released affect The present article elucidates ongoing endeavors field nanoparticle‐mediated therapies management

Language: Английский

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Nanotechnology invigorated drug delivery and tissue engineering strategies for the management of diabetic foot ulcers: Therapeutic approaches and clinical applications

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105665 - 105665

Published: April 16, 2024

Language: Английский

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Advances in Directional Liquid Transport Textiles: Mechanism, Construction, and Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Abstract The seamless integration of emerging directional liquid transport (DLT) technology with traditional textile materials has ushered in the next‐generation multifunctional textiles, i.e., DLT which will play a vital role areas such as wearable smart and ecological environmental protection. To further promote combination technology, concise overview research progress including basic mechanisms, various preparation strategies diversified applications textiles is provided. In this review, theoretical mechanisms from perspective wetting wicking discussed. Besides, categorized them into three categories summarized: fiber‐based fabric‐based fiber/fabric hybrid‐based textiles. Subsequently, current potential are classified discussed, mainly focusing on functional clothing, oil‐water separation, fog collection, distillation, sensors, biomedicine, so on. Finally, challenges prospects to enhance functionality application performance outlined.

Language: Английский

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Preparation of biocompatible Zein/Gelatin/Chitosan/PVA based nanofibers loaded with vitamin E-TPGS via dual-opposite electrospinning method

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 11, 2024

Wound management is a critical aspect of healthcare, necessitating effective and innovative wound dressing materials. Many existing dressings lack effectiveness exhibit limitations, including poor antimicrobial activity, toxicity, inadequate moisture regulation, weak mechanical performance. The aim this study to develop natural-based nanofibrous structure that possesses desirable characteristics for use as dressing. chemical analysis confirmed the successful creation Zein (Ze) (25% w/v) /gelatin (Gel) (10% /chitosan (CS) (2% /Polyvinyl alcohol (PVA) scaffolds loaded with vitamin E tocopheryl polyethylene glycol succinate (Vit E). swelling percentages nanofiber (NF), NF + Vit E, cross-linked (CNF), CNF were 49%, 110%, 410%, 676%, respectively; degradation rates NF, CNF, 29.57 ± 5.06%, 33.78 7.8%, 14.03 7.52%, 43 6.27%, respectively. antibacterial properties demonstrated impregnated antibiotics reduced Escherichia coli (E. coli) counts by approximately 27–28% Staphylococcus aureus (S. aureus) about 34–35% compared negative control. In conclusion, Ze/Gel/CS/PVA have potential suitable materials because environmentally friendly contribute sustainable care controlled ensures breakdown harmlessly.

Language: Английский

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Multifunctional nanocomposites mediated novel hydrogel for diabetic wound repair

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3292 - 3306

Published: Jan. 1, 2024

Synthesis strategy of glucose-responsive intelligent hydrogels based on multifunctional nanocomposite nodes and their mechanism in diabetic infected wounds.

Language: Английский

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