Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(16), P. 9346 - 9346
Published: Aug. 17, 2023
Interleukin-10
(IL-10)
has
anti-inflammatory
properties
and
is
a
crucial
cytokine
in
regulating
immunity.
The
identification
of
IL-10
through
wet
laboratory
experiments
costly
time-intensive.
Therefore,
new
IL-10-induced
peptide
recognition
method,
IL10-Stack,
was
introduced
this
research,
which
based
on
unified
deep
representation
learning
stacking
algorithm.
Two
approaches
were
employed
to
extract
features
from
sequences:
Amino
Acid
Index
(AAindex)
sequence-based
(UniRep).
After
feature
fusion
optimized
selection,
we
selected
1900-dimensional
UniRep
vector
constructed
the
IL10-Stack
model
using
stacking.
exhibited
excellent
performance
(accuracy
(ACC)
=
0.910,
Matthews
correlation
coefficient
(MCC)
0.820).
Relative
existing
methods,
IL-10Pred
ILeukin10Pred,
approach
increased
ACC
by
12.1%
2.4%,
respectively.
method
can
identify
peptides,
aids
development
immunosuppressive
drugs.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(16), P. 3622 - 3622
Published: Aug. 17, 2023
Human
milk
oligosaccharides
(HMOs)
are
a
major
component
of
human
milk.
They
associated
with
multiple
health
benefits
and
manufactured
on
large
scale
for
their
addition
to
different
food
products.
In
this
systematic
review,
we
evaluate
the
outcomes
published
clinical
trials
involving
supplementation
HMOs.
We
screened
PubMed
database
Cochrane
Library,
identifying
26
relevant
five
publications
describing
follow-up
studies.
The
varied
in
study
populations,
including
healthy
term
infants,
infants
medical
indications,
children,
adults.
tested
eight
HMO
structures
individually
or
as
blends
varying
doses.
All
included
safety
tolerance
assessments,
some
also
assessed
growth,
stool
characteristics,
infections,
gut
microbiome
composition,
microbial
metabolites,
biomarkers.
studies
consistently
found
that
was
safe
well
tolerated.
Infant
reported
shift
towards
those
observed
breastfed
intestinal
immune
markers.
Beneficial
system
effects
have
been
other
populations
following
supplementation.
Further
needed
substantiate
understand
structure
dose
dependency.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 6, 2024
Human
milk
oligosaccharides
(HMOs)
can
modulate
the
intestinal
barrier
and
regulate
immune
cells
to
favor
maturation
of
infant
tract
system,
but
precise
functions
individual
HMOs
are
unclear.
To
determine
structure-dependent
effects
(representing
different
structural
classes)
on
epithelium
as
well
innate
adaptive
cells,
we
assessed
fucosylated
(2′FL
3FL),
sialylated
(3′SL
6′SL)
neutral
non-fucosylated
(LNT
LNT2)
for
their
ability
support
integrity,
stimulate
secretion
chemokines
from
epithelial
cytokine
release
LPS-activated
dendritic
(DCs),
M1
macrophages
(MØs),
co-cultures
with
naïve
CD4
+
T
cells.
The
increased
integrity
protected
following
an
inflammatory
insult
exerted
minimal
immunomodulatory
activity.
enhanced
CXCL10,
CCL20
CXCL8
promoted
several
cytokines
(including
IL-10,
IL-12p70
IL-23)
DCs
MØs,
IFN-γ
IL-17A
primed
by
MØs
while
reducing
IL-13.
Thus,
3′SL
6′SL
supported
Th1
Th17
responses
Th2
responses.
Collectively,
our
data
show
that
exert
possess
properties
confer
benefits
infants
possibly
also
later
in
life.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(12), P. 6536 - 6552
Published: Jan. 1, 2024
A
total
of
ninety-six
weaned
piglets
were
assigned
to
four
dietary
treatments
in
a
2
×
design.
The
included:
standard
milk
formula
(CTR);
CTR
+
probiotics
(6.4
10
Immunology,
Journal Year:
2024,
Volume and Issue:
173(3), P. 562 - 574
Published: Aug. 6, 2024
Group
2
innate
lymphoid
cells
(ILC2s)
play
a
crucial
role
in
the
progression
of
asthma,
yet
regulatory
mechanisms
modulating
ILC2
responses
asthma
remain
underexplored.
Human
milk
oligosaccharides
(HMOs),
vital
non-nutritive
components
breast
milk,
are
known
to
significantly
shape
immune
system
development
and
influence
incidence
allergic
diseases.
However,
their
impact
on
ILC2-driven
is
not
fully
understood.
Our
research
reveals
that
dietary
HMOs
act
as
potent
inhibitors
airway
inflammation.
Treatment
with
2'-fucosyllactose
(2'-FL)
6'-sialyllactose
(6'-SL)
reduced
ILC2-related
inflammation
induced
by
papain
or
Alternaria
alternata
mice,
evidenced
decreased
eosinophil
(EOS)
infiltration
lower
IL-5
IL-13
levels
BALF.
Notably,
while
expresses
HMO
receptors,
did
directly
but
potentially
modulated
activity
through
alterations
gut
microbiota
derived
SCFAs.
treatments
alleviated
SCFA-dependent
manners,
SCFA
depletion
receptor
blocking
reversing
these
beneficial
effects.
This
study
potential
managing
modulation
gut-lung
axis,
proposing
new
therapeutic
avenue
utilises
immunomodulatory
capacities
nutritional
combat
respiratory
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Purpose
of
review:
Human
milk
is
the
optimal
food
choice
for
infants.
Reviewing
latest
advances
in
research
about
human
compounds
and
their
effect
on
health
helps
understand
benefits
breastfeeding
improves
knowledge
key
bioactive
nutrients
that
can
be
used
to
improve
feeding
during
infancy,
with
short
long-time
effects
health.
Recent
findings:
In
last
years,
it
has
been
described
how
such
as
oligosaccharides,
hormones,
lipids,
cellular
components
microbes
play
an
important
role
infants’
health,
reducing
risk
infectious,
metabolic
autoimmune
diseases.
The
mechanisms
transmission
from
mother
infant
these
are
not
always
well
described,
but
there
several
lines
biological
beneficial
effects.
Summary:
These
findings
may
help
maternal
interventions,
modifiable
factors
able
modulate
composition.
They
development
formulas
enhance
nutritional
plans.
Also,
identification
isolation
describe
new
ways
supplementation.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 19, 2025
Allergic
asthma
is
characterized
by
sensitization
to
airborne
allergens
like
house
dust
mite
(HDM).
Human
milk
oligosaccharides
(HMOS)
are
linked
improved
immune
maturation
and
potentially
alleviate
allergy
development.
A
human
in
vitro
model
for
crosstalk
between
bronchial
epithelial
cells
(BECs),
monocyte-derived
DCs
(moDCs)
T
cells,
during
HDM
exposure,
was
established.
The
immunomodulatory
effects
of
the
HMOS
2'-fucosyllactose
(2'FL)
3-fucosyllactose
(3FL)
were
investigated
this
subsequently
a
mite-induced
allergic
murine
model.
exposure
BEC-DC
coculture
enhanced
type
2
instructing
TSLP,
while
reducing
regulatory
TGFβ
secretion.
Coculture
HDM-primed
with
IL4
2'FL
or
3FL
preincubation
prevented
HDM-induced
TSLP
IL8
release
from
BEC-DC.
HDM-allergic
mice
receiving
1%
0,5%
supplemented
diet
both
had
lower
serum
levels
HDM-specific
IgE
compared
fed
control
diet.
In
conclusion,
activation
subsequent
cell
response
modified
downstream
responses
vitro.
Both
reduced
asthma,
but
did
not
protect
against
airway
inflammation.
Here,
we
describe
an
mucosal
as
relevant
tool
reduce
use
animals
studies
aiming
prevent
asthma.
well
vivo,
found
drive
away
signature,
paving
way
further
investigate
potential
preventive
fucosylated
HMOS.
Biology,
Journal Year:
2025,
Volume and Issue:
14(3), P. 299 - 299
Published: March 16, 2025
The
development
of
the
human
immune
system
starts
during
fetal
period
in
a
largely,
but
probably
not
completely,
sterile
environment.
During
and
after
birth,
is
exposed
to
an
increasingly
complex
microbiota.
first
microbiota
encountered
passage
through
birth
canal
colonize
infant
gut
induce
tolerance
system.
Transplacentally
derived
maternal
IgG
as
well
IgA
from
breast
milk
protect
infections
100
days,
which
further
develops
immunological
memory
formed.
Weaning
introduction
solid
food
expose
novel
(food)
antigens
allow
for
other
colonize.
cells
molecules
involved
mutual
intricate
interactions
between
developing
are
now
beginning
be
recognized.
These
include
bacterial
components
such
polysaccharide
A
Bacteroides
fragilis,
metabolites
short-chain
fatty
acid
butyrate,
indole-3-aldehyde,
indole-3-propionic
acid.
All
these,
more,
have
specific
immunoregulatory
functions
shape
1000
days
life.
