Virtual screening of azoles libraries: the search for potential anti-mucormycotic agents using computational tools DOI Creative Commons
Ahlam Haj Hasan, Gagan Preet, Rishi Vachaspathy Astakala

et al.

Network Modeling Analysis in Health Informatics and Bioinformatics, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 15, 2025

Language: Английский

Biosurfactants: Promising Biomolecules for Agricultural Applications DOI Open Access
Maria da Glória C. Silva, Anderson O. de Medeiros, Attílio Converti

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(1), P. 449 - 449

Published: Jan. 4, 2024

Population growth and the need for increased agricultural productivity pose a global problem. Therefore, development of green compounds to ensure sustainability is an urgent necessity. Surfactant hold significant commercial importance due their diverse industrial uses. However, synthetic origin these agents limits application toxicity. As result, extensive research has focused on production microbial-originated surfactants, known as biosurfactants, over past fifteen years. These biomolecules not only offer alternative agriculture but also exhibit reduced toxicity excellent stability under specific environmental conditions. Biosurfactants can lower surface tension more effectively than surfactants. With properties such detergency foam formation, biosurfactants are suitable various applications, particularly in pesticide agrochemical formulations. They function biopesticides manage pests, pathogens, phytopathogenic fungi, weeds antimicrobial activity. Moreover, plants benefit from biosurfactant molecules microorganisms nutrients. aid efficiently distribution micronutrients metals soil. stimulate plant immunity utilized soil hydrophilization proper moisture levels uniform fertilizer distribution. This review aims provide valuable insights into role adjuvants, fostering sustainable formulations replace chemical surfactants used pesticides. For this purpose, general aspects activity initially described, followed by discussion pesticides, including herbicides, fungicides, insecticide products. Next, discussed use with emphasis microbial demonstrated. The industry trends addressed prospects discussed.

Language: Английский

Citations

31

Recent advances in the application of microbial biosurfactants in food industries: Opportunities and challenges DOI

Anushree Roy,

Mojibur R. Khan, Ashis K. Mukherjee

et al.

Food Control, Journal Year: 2024, Volume and Issue: 163, P. 110465 - 110465

Published: March 25, 2024

Language: Английский

Citations

10

Synthetic biology drives innovative advances of antimicrobial peptide iturin A DOI
Daiyuan Zhang,

Mo Zhang,

Dian Zou

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104907 - 104907

Published: Feb. 1, 2025

Language: Английский

Citations

2

Bio-Based Surfactants and Biosurfactants: An Overview and Main Characteristics DOI Creative Commons
Gloria Romero Vega, Paola Gallo Stampino

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 863 - 863

Published: Feb. 13, 2025

Natural surfactants are surface-active molecules synthesized from renewable resources (i.e., plants, animals, or microorganisms) and possess properties comparable to conventional surfactants, making them an environmentally friendly potential alternative petrochemical surfactants. Additionally, they exhibit biological such as anti-microbial properties, biodegradability, less toxicity, allowing their use in everyday products with minimal risk human health the environment. Based on mode of production, natural can be classified into first-generation bio-based second-generation biosurfactants, although definition may vary depending author literature. This review offers extensive classification focusing composition, sources, production methods, applications across various industries. Furthermore, main challenges future perspectives discussed.

Language: Английский

Citations

2

Novel fermentation strategy utilizing a probiotic complex to improve the feeding value of distillers’ grains DOI Creative Commons
Zhiwei Wang, Yangguang Li, Haoran Tang

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 226, P. 120748 - 120748

Published: Feb. 20, 2025

Language: Английский

Citations

2

Secondary Metabolites from Bacillus spp. Probiotics as Potential Treatments for Multidrug-Resistant Pathogens: A Comprehensive Review DOI Creative Commons

Gaston Nicolas

Current Research in Microbial Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 100392 - 100392

Published: April 1, 2025

The discovery of antibiotics is a significant medical breakthrough, saving millions lives. However, the widespread misuse and overuse led to development antimicrobial resistance. Spore-forming probiotics from Bacillus spp. show great interest as agents through production strain-specific bioactive secondary metabolites. This review summarizes broad-spectrum activities metabolite groups their reported mechanisms action, underscoring urgency in developing novel drugs.

Language: Английский

Citations

1

Microbial lipopeptides: their pharmaceutical and biotechnological potential, applications, and way forward DOI

K. P. Sreelakshmi,

M. Madhuri,

R. Swetha

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(4)

Published: March 15, 2024

Language: Английский

Citations

8

Insights into the antifungal mechanism of Bacillus subtilis cyclic lipopeptide iturin A mediated by potassium ion channel DOI

Saixue Yang,

Yulan Ji,

Pengyuan Xue

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134306 - 134306

Published: July 31, 2024

Language: Английский

Citations

8

Antimicrobial Activity of Bacillus Cyclic Lipopeptides and Their Role in the Host Adaptive Response to Changes in Environmental Conditions DOI Open Access
Н. Н. Маркелова,

Anastasia Chumak

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 336 - 336

Published: Jan. 2, 2025

Bacillus cyclic lipopeptides (CLP), part of the three main families—surfactins, iturins, and fengycins—are secondary metabolites with a unique chemical structure that includes both peptide lipid components. Being amphiphilic compounds, CLPs exhibit antimicrobial activity in vitro, damaging membranes microorganisms. However, concentrations used vitro are difficult to achieve natural conditions. Therefore, environment, alternative mechanisms action by more likely, such as inducing apoptosis fungal cells, preventing microbial adhesion substrate, promoting death phytopathogens stimulating plant immune responses. In addition, low act signaling molecules Bacillus’s own metabolism, when environmental conditions change, they form an adaptive response host bacterium. Namely, trigger differentiation bacterial population into various specialized cell types: competent flagellated matrix producers, spores. this review, we have summarized current understanding under experimental We also shown relationship between some regulatory pathways involved CLP biosynthesis differentiation, well role determine changes physiological state subpopulations shifts

Language: Английский

Citations

1

Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides DOI Creative Commons
Rina Aoki,

Eri Kumagawa,

Kazuaki Kamata

et al.

Communications Chemistry, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 21, 2025

Abstract Cyclic lipopeptides (CLPs) produced by the genus Bacillus are amphiphiles composed of hydrophilic amino acid and hydrophobic fatty moieties biosynthesised non-ribosomal peptide synthetases (NRPSs). CLPs as a mixture homologues with different moieties, whose length affects CLP activity. Iturin family comprising cyclic heptapeptides β-amino acids have antimicrobial There is little research on how moiety iturin determined. Here, we demonstrated that acyl ligase (AL) domain determines in vivo. In addition, enzyme assays revealed mutations substrate-binding pocket AL affected substrate specificity vitro. Our findings implications for design synthesis using NRPS.

Language: Английский

Citations

1