Electrically Conductive Collagen‐PEDOT:PSS Hydrogel Prevents Post‐Infarct Cardiac Arrhythmia and Supports hiPSC‐Cardiomyocyte Function

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 23, 2024

Abstract Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden cardiac (SCD). The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling disease progression do not prevent arrhythmia. This work develops an injectable collagen‐PEDOT:PSS (poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate) hydrogel that protects infarcted hearts against ventricular tachycardia (VT) can be combined with human induced pluripotent stem (hiPSC)‐cardiomyocytes promote partial remuscularization. PEDOT:PSS improves collagen gel formation, micromorphology, conductivity. hiPSC‐cardiomyocytes hydrogels exhibit near‐adult sarcomeric length, improved contractility, enhanced calcium handling, conduction velocity. RNA‐sequencing data indicate maturation cell‐matrix interactions. Injecting mouse decreases VT the levels healthy hearts. Collectively, offer a versatile platform treating injuries.

Language: Английский

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Signaling pathways activated and regulated by stem cell-derived exosome therapy

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Stem cell-derived exosomes exert comparable therapeutic effects to those of their parental stem cells without causing immunogenic, tumorigenic, and ethical disadvantages. Their advantages are manifested in the management a broad spectrum diseases, dosing versatility exemplified by systemic administration local delivery. Furthermore, activation regulation various signaling cascades have provided foundation for claimed curative exosomal therapy. Unlike other relevant reviews focusing on upstream aspects (e.g., yield, isolation, modification), downstream (e.g. phenotypic changes, tissue response, cellular behavior) exosome therapy, this unique review endeavors focus affected pathways. After meticulous dissection literature from past five years, we present comprehensive, up-to-date, disease-specific, pathway-oriented review. Exosomes sourced types can regulate major pathways PTEN/PI3K/Akt/mTOR, NF-κB, TGF-β, HIF-1α, Wnt, MAPK, JAK-STAT, Hippo, Notch cascades) minor during treatment numerous diseases encountered orthopedic surgery, neurosurgery, cardiothoracic plastic general specialties. We provide novel perspective future research through bridging gap between surgical indications when designing further preclinical studies clinical trials.

Language: Английский

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Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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Conducting Polymers-Based Gas Sensors: Principles, Materials, and Applications

Sensors, Journal Year: 2025, Volume and Issue: 25(9), P. 2724 - 2724

Published: April 25, 2025

Conducting polymers (CPs) have emerged as promising materials for gas sensors due to their organic nature coupled with unique and versatile optical, electrical, chemical, electrochemical properties. This review provides a comprehensive overview of the latest developments in conducting polymer-based sensors. First, fundamental sensing mechanisms CPs-based are elucidated, covering diverse transduction modes including electrochemical, chemiresistive, piezoelectric, field-effect transistor-based sensing. Next, various types employed sensors, such polypyrrole, polyaniline, polythiophene, composites introduced, emphasis on synthesis methods, structural characteristics, response Finally, wide range applications these is discussed, spanning industrial process control, environmental monitoring, food safety, biomedical diagnosis, other fields, well existing issues long-term stability humidity interference, summary biocompatibility regulatory standards conductive provided. By integrating insights from mechanisms, materials, applications, this offers holistic understanding It also highlights future research directions, device miniaturization, AI-assisted identification, multifunctional integrated systems, wearable flexible sensor platforms, enhanced sensitivity, selectivity, on-site detection capabilities.

Language: Английский

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Conducting Polymer PEDOTs for Biomedical Application

Synthetic Metals, Journal Year: 2024, Volume and Issue: 307, P. 117700 - 117700

Published: July 17, 2024

Language: Английский

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Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have used to simulate cochlear structures replicate functions. However, physical chemical cues required control development organoids accurately remain poorly understood, limiting research advances cochlea‐on‐a‐chip systems. Consequently, platforms that provide reliable preclinical testing grounds for studying inner ear developmental mechanisms screening‐related therapeutic drugs become a key focus future technologies. In this review, recent advancements in technology are summarized. First, an overview anatomy physiology is provided. Next, latest breakthroughs discussed 3D cultivation explore progress microfluidic technologies constructing Finally, perspectives presented challenges directions developing technology.

Language: Английский

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