Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1775 - 1775
Published: Aug. 6, 2024
The
aim
of
the
project
was
to
evaluate
association
between
selenium
(Se)
and
zinc
(Zn)
levels
in
blood
serum
kidney
cancer
mortality.
In
a
prospective
group
284
consecutive,
unselected
patients
with
cancer,
we
evaluated
their
10-year
survival
rate
relation
Se
Zn
serum.
Micronutrient
were
measured
using
an
inductively
coupled
plasma
mass
spectrometer.
Patients
divided
into
quartiles
based
on
distribution
arranged
increasing
order.
following
variables
taken
account
multivariable
models:
age
at
diagnosis,
gender,
smoking,
type
surgery
histopathological
examination
results.
We
observed
statistically
significant
all-cause
mortality
when
subgroups
low
compared
high
(HR
=
7.74;
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Jan. 19, 2023
The
slightest
change
in
the
extra/intracellular
concentration
of
metal
ions
results
amplified
effects
by
signaling
cascades
that
regulate
both
cell
fate
within
tumor
microenvironment
and
immune
status,
which
influences
network
antitumor
immunity
through
various
pathways.
Based
on
fact
influence
cancer
cells
participate
innate
adaptive
immunity,
they
are
widely
applied
therapy
as
modulators.
Moreover,
nanomedicine
possesses
advantage
precise
delivery
responsive
release,
can
perfectly
remedy
drawbacks
ions,
such
low
target
selectivity
systematic
toxicity,
thus
providing
an
ideal
platform
for
ion
application
treatment.
Emerging
evidence
has
shown
immunotherapy
with
nanometallic
materials
may
significantly
enhance
therapeutic
efficacy.
Here,
we
focus
physiopathology
tumorigenesis
discuss
several
breakthroughs
regarding
use
immunotherapeutics.
These
findings
demonstrate
prominence
ion-based
prophylaxis,
many
new
ideas
basic
research
clinical
application.
Consequently,
provide
innovative
insights
into
comprehensive
understanding
combined
past
few
years.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Diabetic
wound
healing
(DWH)
represents
a
major
complication
of
diabetes
where
inflammation
is
key
impediment
to
proper
healing.
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
signaling
pathway
has
emerged
as
central
mediator
inflammatory
responses
cell
stress
and
damage.
However,
the
contribution
cGAS-STING
activation
impaired
in
DWH
remains
understudied.
In
this
review,
we
examine
evidence
that
cGAS-STING-driven
critical
factor
underlying
defective
DWH.
We
summarize
studies
revealing
upregulation
diabetic
wounds
discuss
how
exacerbates
senescence
disrupts
cellular
metabolism
block
Partial
pharmaceutical
inhibition
shown
promise
damping
improving
preclinical
models.
highlight
knowledge
gaps
regarding
DWH,
including
its
relationships
with
endoplasmic
reticulum
metal-ion
signaling.
Elucidating
these
mechanisms
may
unveil
new
therapeutic
targets
within
improve
outcomes
This
review
synthesizes
current
understanding
contributes
pathology
proposes
future
research
directions
exploit
modulation
for
benefit.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(10), P. 1048 - 1048
Published: Oct. 2, 2023
Trace
metal
elements
are
of
vital
importance
for
fundamental
biological
processes.
They
function
in
various
metabolic
pathways
after
the
long
evolution
living
organisms.
Glucose
is
considered
to
be
one
main
sources
energy
that
supports
activities,
and
its
metabolism
tightly
regulated
by
trace
such
as
iron,
zinc,
copper,
manganese.
However,
there
still
a
lack
understanding
regulation
glucose
elements.
In
particular,
underlying
mechanism
action
remains
elucidated.
this
review,
we
summarize
current
concepts
progress
linking
metabolism,
particularly
manganese,
iron.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(33), P. 43156 - 43170
Published: Aug. 12, 2024
Metal-organic
frameworks
(MOFs)
are
composite
crystalline
materials
created
through
the
coordination
of
metal
ions
and
organic
ligands.
MOFs
have
attracted
extensive
attention
in
biomedical
field
based
on
advantages
internal
porosity,
customizable
facile
surface
modification.
This
review
examines
utilization
drug
delivery
systems,
focusing
research
progress
from
aspects
coloading
intelligent
responsive
carriers,
biological
macromolecule
stabilizers,
self-driving
micro/nanomotors,
multifunctional
living
carriers.
In
addition,
current
challenges
faces
also
discussed.
The
aims
to
provide
a
reference
for
further
application
as
advanced
systems.
Bioinorganic Chemistry and Applications,
Journal Year:
2022,
Volume and Issue:
2022(1)
Published: Jan. 1, 2022
Solid
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
hypoxia,
low
acidity,
and
high
hydrogen
peroxide
glutathione
(GSH)
levels,
among
others.
These
factors,
offer
favourable
microenvironments
nourishment
for
development
spread,
also
serve
as
gateway
specific
successful
cancer
therapies.
A
good
example
is
metal
structures
been
synthesized
utilized
to
enhance
oxygen
supply
they
shown
great
promise
in
the
alleviation
of
hypoxia.
In
hypoxic
environment,
certain
oxygen‐dependent
treatments
such
photodynamic
therapy
radiotherapy
fail
respond
therefore
modulating
has
found
antitumor
impact
drugs.
Under
acidic
environments,
produced
by
reaction
peroxides
with
water
not
only
induces
oxidative
stress
but
produces
additional
oxygen.
This
achieved
since
acts
reactive
substrate
molecules
catalyse
enzymes,
alleviating
hypoxia
observed
microenvironment.
Metal
ions
released
process
can
distinct
bioactivity
their
own
right.
used
anticancer
are
rapidly
evolving
field,
there
evidence
that
option
regulating
therapy.
this
regard,
synthesis
mechanisms
behind
application
specifically
target
highlighted
review.
Various
characteristics
TME
angiogenesis,
inflammation,
acidity
ion
homeostasis
addressed
together
forms
synergistic
combination
treatments.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 19, 2023
As
an
essential
micronutrient,
manganese
plays
important
role
in
the
physiological
process
and
immune
process.
In
recent
decades,
cGAS-STING
pathway,
which
can
congenitally
recognize
exogenous
endogenous
DNA
for
activation,
has
been
widely
reported
to
play
critical
roles
innate
immunity
against
some
diseases,
such
as
infections
tumor.
Manganese
ion
(Mn2+)
recently
proved
specifically
bind
with
cGAS
activate
pathway
a
potential
agonist,
however,
is
significantly
restricted
by
low
stability
of
Mn2+
further
medical
application.
one
most
stable
forms
manganese,
dioxide
(MnO2)
nanomaterials
have
show
multiple
promising
functions,
drug
delivery,
anti-tumor
anti-infection
activities.
More
importantly,
MnO2
are
also
found
be
candidate
agonist
transforming
into
Mn2+,
indicates
their
regulations
different
diseased
conditions.
this
review,
we
introduced
methods
preparation
well
biological
Moreover,
emphatically
discussed
detailed
mechanisms
activation
converting
Mn2+.
And
application
disease
treatment
regulating
might
benefit
future
development
novel
targeted
treatments
based
on
nanoplatforms.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(28), P. 10753 - 10769
Published: Jan. 1, 2024
A
water-soluble,
cell-permeable,
turn-on
Mn
2+
sensor
visualizes
dynamics
live
and
provides
an
estimate
for
endogenous
labile
in
a
living
mammalian
cell.
