Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 205 - 205

Published: Jan. 15, 2025

Background: Poor oral health and periodontitis have been epidemiologically linked to cognitive decline mild impairment (MCI) in older adults. However, specific metrics directly linking these clinical signs are exceedingly limited. Methods: To address this gap develop novel tools help clinicians identify individuals at risk of decline, we established the PerioMind Colombia Cohort, comprising elderly Colombian subjects who underwent comprehensive neurocognitive periodontal evaluations. Results: The results revealed that diagnosed with MCI exhibited significantly higher scores indices, including gingival erythema pocket depth parameters. predictive model identified positive associations MCI, showing strongest correlation, followed by presence variations measurements. Additionally, lower educational attainment was associated a likelihood being classified periodontitis-MCI group. Conclusions: Here, show altered diagnosis, generated provide defined metric ranges for identifying risk. Upon validation larger cohorts, findings reported here could offer dental practitioners innovative age-related dementias through routine assessments, thereby enabling more accessible highly sought-after early intervention strategies both developing developed countries.

Language: Английский

---

The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2749 - 2749

Published: Oct. 11, 2023

The human oral microbiome has emerged as a focal point of research due to its profound implications for health. involvement short-chain fatty acids in composition, health, and chronic inflammation is gaining increasing attention. In this narrative review, the results early vitro, vivo, pilot clinical studies projects are presented order define boundaries new complicated issue. According results, current data disputable ambiguous. When investigating role SCFAs health disease, it crucial distinguish between their local GI effects systemic influences. Locally, part normal microbiota metabolism, but increased formation usually attribute dysbiosis; excess participate development diseases biota gut colonization dysbiosis. On other hand, number have established positive impact on whole, including reduction inflammation, improvement metabolic processes, decrease some types cancer incidence. Thus, complex sophisticated approach with consideration origin localization SCFA function assessment demanded. Therefore, more research, especially needed investigate relationship disease potential prevention treatment.

Language: Английский

---

Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

---

A Holistic Approach for Ethics and Sustainability in the Food Chain: The Gateway to Oral and Systemic Health

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1224 - 1224

Published: April 17, 2024

Food production is a complex matter, affecting people’s lives, organizations’ profits, and the well-being of whole planet, has multifaceted ethical considerations surrounding its production, distribution, consumption. This paper addresses pressing need to confront challenges within food system, encompassing issues such as environmental sustainability, security, individual choices for better oral systemic health all individuals around globe. From agricultural practices global trade waste, implications are addressed across various domains, highlighting interconnectedness decision-making in industry. Central themes explored include dimensions methods, impact on ethics, role making ethically informed choices. Additionally, this considers spiritual physical significance food, particularly through lens gateway holistic well-being. Recognizing complexity mouth ecosystem, calls serious interventions legislation economics promote protocols techniques sustainability reasons. It emphasizes importance safety management systems, regulatory frameworks, quality standards. Moreover, underlines comprehensive approach address dilemmas moral values inherent industry policies, adopting precautionary principle frameworks. article finally aims serve call action stakeholders healthcare sector, prioritize practices, transparency, rearrange economic parameters, work towards more sustainable equitable system inner outer human all.

Language: Английский

---

Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1416 - 1416

Published: Aug. 29, 2024

Periodontitis can disrupt oral and gut microbiota, leading to dysbiosis that affects overall systemic health. Besides the spread of periodontal pathogens by hematogenous route, they also be translocated into gastrointestinal tract, possibly intervening in neoplastic process tract. This manuscript reviews relationship between microbiota due periodontitis, discussing health implications potential links cancer. article highlights significance effect gut, emphasizing importance maintaining prevent diseases. Lastly, it will go through therapeutic innovations such as probiotics analysis tools for disease detection. These findings mark integration management clinical practice lower risk improve patient outcomes.

Language: Английский

---

The Interaction between the Oral Microbiome and Systemic Diseases: A Narrative Review

Microbiology Research, Journal Year: 2023, Volume and Issue: 14(4), P. 1862 - 1878

Published: Nov. 9, 2023

Background: The human being is defined as a ‘superorganism’ since it made up of its own cells and microorganisms that reside inside outside the body. Commensal microorganisms, which are even ten times more numerous than present in body, perform very important functions for host, they contribute to health resist pathogens, maintain homeostasis, modulate immune system. In mouth, there different types such viruses, mycoplasmas, bacteria, archaea, fungi, protozoa, often organized communities. aim this umbrella review evaluate if connection between oral microbiome systematic diseases. Methodology: A literature search was conducted through PubMed/MEDLINE, COCHRANE library, Scopus, Web Science databases without any restrictions. Because large number articles included wide range methods results among studies found, not possible report form or meta-analysis. Therefore, narrative conducted. We obtained 73.931 results, 3593 passed English language filter. After screening titles abstracts, non-topic entries were excluded, but most concerned interactions systemic Discussion: description normal microbial flora cavity both physiological conditions local pathological widespread pathologies. Furthermore, therapeutic precautions clinician can follow order intervene on change have been described. Conclusions: This highlights what intercorrelations microbiota healthy subjects conditions. According several recent studies, clear correlation dysbiosis diseases diabetes, cardiovascular diseases, chronic inflammatory neurodegenerative

Language: Английский

---

Exploring the role of oral bacteria in oral cancer: a narrative review

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.

Language: Английский

---

Is the oral pathogen, Porphyromona gingivalis, associated to colorectal cancer?: a systematic review

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 4, 2025

The association between the oral pathogen Porphyromonas gingivalis (PG) and gut microbiota in colorectal cancer (CRC) patients has been explored with inconsistent results. This study aims to systematically assess this potential association. A systematic review was conducted across three databases (Pubmed, Embase Web of Science) from inception up January 2023 updated until November 2024. Inclusion criteria were observational studies examining PG adults CRC compared healthy controls. Exclusion without control group individuals, other designs or full-text access. Two reviewers independently selected extracted data following a pre-registered protocol. Disagreements resolved by consensus third reviewer. Risk bias (RoB) assessed using Newcastle-Ottawa Scale (NOS). Results summarized flow diagram, tables, narrative descriptions. Meta-analysis not feasible, so Fisher's method for combining p-values sign test used as alternative integration methods. Finally, 18 studies, 23 analysis units included, providing total sample 4,373 participants (48.0% cases 52.0%controls), 38.2% men 61.8% women, similar distribution among mean (SD) age 63.3 (4.382) years old 57.0 (7.753) Most analyzed presence feces (70.0%) collected before colonoscopy (55.0%) classified good quality RoB assessment. suggested an effect (Fisher's test, p = .000006) some evidence towards positive controls (Sign .039). suggest that is associated patients. Lack information calculate size prevented performance meta-analysis. Future research should aim standardized protocols statistical approaches. No funding received work. protocol registered International Prospective Register Systematic Reviews (PROSPERO) on (registration number: CRD42023399382).

Language: Английский

---

The Oral–Gut Microbiome–Brain Axis in Cognition

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

---

Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 26, 2024

Abstract The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ diseases do not occur in isolation, comprehensive analysis strategy highlighting the full potential of should include diverse specimen types diseases. To ensure robust data quality comparability across diseases, we employ standardized protocols to generate sequencing from 1931 prospectively collected specimens, including saliva, plaque, skin, throat, eye, stool, with an average depth 5.3 gigabases. Collected 515 patients, these samples yield 3.7 metagenomes per patient. Our results suggest significant microbial variations types, unexpected anatomical sites. We identify 583 unexplored species-level genome bins (SGBs) which 189 are significantly disease-associated. Of note, existence resistance genes one was indicative same other specimens Annotated previously undescribed SGBs collectively harbor 28,315 biosynthetic gene clusters (BGCs), 1050 correlations combinatorial approach identifies distinct BGCs, emphasizing value pan-body pan-disease microbiomics source therapeutic strategies.

Language: Английский

---