Metadherin-driven promotion of cancer stem cell phenotypes and its effect on immunity in hepatocellular carcinoma DOI Creative Commons
Nevena Todorović,

Amedeo Amedei

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(20), P. 2624 - 2628

Published: May 27, 2024

In this editorial we provide commentary on the article published by Wang et al , featured in recent issue of World Journal Gastroenterology 2024. We focus metadherin (MTDH), also known as astrocyte elevated gene-1 or lysine rich CEACAM1, and its effects cancer stem cells (CSCs) immunity hepatocellular carcinoma (HCC). HCC is most common primary liver one leading causes cancer-related deaths worldwide. Most cases develop context cirrhosis. Among pivotal mechanisms carcinogenesis are gene mutations, dysregulation diverse signaling pathways, epigenetic alterations, hepatitis B virus-induced hepatocarcinogenesis, chronic inflammation, impact tumor microenvironment, oxidative stress. Over years, extensive research has been conducted MTDH role various pathologies, such lung, breast, ovarian, gastric, hepatocellular, colorectal, renal carcinoma, neuroblastoma, melanoma, leukemias. Specifically, involvement development processes including transformation, apoptosis evasion, angiogenesis, invasion, metastasis via multiple pathways. It demonstrated that knockdown knockout disrupt metastasis. addition, numerous reports have carried out regarding influence HCC, demonstrating a predictor poor prognosis, aggressive phenotypes prone to recurrence, exhibiting significant potential for therapy resistance. Finally, more studies finely investigated CSCs. The CSCs small subpopulation sharing traits with normal like self-renewal differentiation abilities, alongside high plasticity alters their phenotype. Beyond presumed initiation, they can drive disease relapse, metastasis, resistance chemo radiotherapy.

Language: Английский

Converting “cold” to “hot”: epigenetics strategies to improve immune therapy effect by regulating tumor‐associated immune suppressive cells DOI Creative Commons

Yijia Tang,

Guangzu Cui,

Haicong Liu

et al.

Cancer Communications, Journal Year: 2024, Volume and Issue: 44(6), P. 601 - 636

Published: May 7, 2024

Abstract Significant developments in cancer treatment have been made since the advent of immune therapies. However, there are still some patients with malignant tumors who do not benefit from immunotherapy. Tumors without immunogenicity called “cold” which unresponsive to immunotherapy, and opposite “hot” tumors. Immune suppressive cells (ISCs) refer can inhibit response such as tumor‐associated macrophages (TAMs), myeloid‐derived suppressor (MDSCs), regulatory T (Treg) so on. The more ISCs infiltrated, weaker tumor, showing characteristics tumor. dysfunction tumor microenvironment (TME) may play essential roles insensitive therapeutic reaction. Previous studies found that epigenetic mechanisms an important role regulation ISCs. Regulating be a new approach transforming into Here, we focused on function TME discussed how epigenetics is involved regulating In addition, summarized by drugs convert immunotherapy‐insensitive immunotherapy‐sensitive would innovative tendency for future immunotherapy

Language: Английский

Citations

12
Biological Activity of Natural and Synthetic Peptides as Anticancer Agents DOI Open Access
Luana Vittoria Bauso,

Valeria La Fauci,

S. Munaò

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7264 - 7264

Published: July 1, 2024

Cancer is one of the leading causes morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, surgical treatment are most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, discovery new effective alternative therapies still represents an enormous challenge for tumour diseases. Recently, anticancer peptides (ACPs) have gained attention cancer diagnosis treatment. ACPs small bioactive molecules which selectively induce cell through variety mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, well inhibition angiogenesis, survival, proliferation pathways. can also be employed targeted delivery drugs into cells. With over 1000 clinical trials using ACPs, potential application in therapy seems promising. Peptides utilized conjunction with imaging agents molecular methods, MRI, PET, CT, NIR, improving detection classification cancer, monitoring response. In this review we will provide overview biological activity some natural synthetic common malignant tumours affecting people around world.

Language: Английский

Citations

9
Automated Ultrasonography of Hepatocellular Carcinoma using Discrete Wavelet Transform based Deep-learning Neural Network DOI Creative Commons
Se-Yeol Rhyou, Jae-Chern Yoo

Medical Image Analysis, Journal Year: 2025, Volume and Issue: 101, P. 103453 - 103453

Published: Jan. 5, 2025

Language: Английский

Citations

1
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development DOI Creative Commons
Haijun Zhang, Lin Zhang, Zhichao Wu

et al.

Cell Division, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 17, 2025

Dysregulation of SF3A3 has been related to the development many cancers. Here, we investigated functional role in hepatocellular carcinoma (HCC). expression HCC tissues and cell lines was examined using RT-qPCR. Changes malignant behavior cells after downregulation were assessed by EdU, colony formation, flow cytometry, wound healing, Transwell invasion assays. Multiple datasets combined identify upstream modifiers SF3A3. The binding relationship between STIL FOXM1 explored co-IP assay, effect on at promoter detected ChIP-qPCR assay. A xenograft tumor model established explore changes tumors vivo, Ki67, GPC3, p53 immunohistochemistry. overexpressed cells, or inhibited promoting p53. An interaction regulated cells. Knockdown further enhanced anti-tumor effects loss vitro whereas overexpression overturned impact vivo. Our findings indicate that STIL/FOXM1 expedites activating SF3A3, which highlights importance as a promising prognostic marker therapeutic target for HCC.

Language: Английский

Citations

1
Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy DOI Creative Commons
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1166 - 1166

Published: April 13, 2023

The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated. Autophagy and apoptosis are two important cellular pathways critical for cell survival or death. balance between autophagy regulates liver turnover maintains intracellular homeostasis. However, the often dysregulated in many cancers, including HCC. may be either independent parallel one influence other. inhibit promote apoptosis, thus regulating fate cancer cells. In this review, concise overview HCC presented, with emphasis on new developments, role endoplasmic reticulum stress, implication microRNAs gut microbiota. characteristics associated specific disease also described brief description provided. initiation, progress metastatic potential reviewed experimental evidence indicating an interplay extensively analyzed. ferroptosis, recently pathway regulated death, presented. Finally, therapeutic implications drug resistance examined.

Language: Английский

Citations

21
Development and Characterization of Graphene Oxide-Locust Bean Gum-Zinc Oxide (GO-LBG-ZnO) Nanohybrid as an Efficient and Novel Antitumor Agent against Hepatocarcinoma Cells DOI

Samane Shakibaie,

Hoomaan Joze-Majidi,

Erfan Zabihi

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: 32(7), P. 3422 - 3435

Published: Jan. 23, 2024

Language: Английский

Citations

4
Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges DOI Creative Commons

Abdullah Al Jabri,

Jibran Ahmad Khan, Bader Taftafa

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(4), P. 346 - 346

Published: April 1, 2024

Hepatic cancer is widely regarded as the leading cause of cancer-related mortality worldwide. Despite recent advances in treatment options, prognosis liver remains poor. Therefore, there an urgent need to develop more representative vitro models for pathophysiology and drug screening studies. Fortunately, exciting new development generating years has been advent organoid technology. Organoid hold huge potential research tool because they can recapitulate spatial architecture primary cancers maintain molecular functional variations native tissue counterparts during long-term culture vitro. This review provides a comprehensive overview discussion establishment application Bioengineering strategies used construct are also discussed. In addition, clinical other relevant applications different states explored. end, this discusses current limitations future prospects encourage further development.

Language: Английский

Citations

4
Unlocking the potential of gold nanoparticles as a game-changer in the fight against hepatocellular carcinoma DOI Creative Commons
Sarmistha Saha, Manish Taneja, S. Dubey

et al.

Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

According to research, hepatocellular carcinoma (HCC), ranks third globally in terms of cause death and is the fifth most common type cancer overall. Finding novel means diagnosis treatment therefore crucial. The use nanotechnology as a has drawn lot interest recently. Despite significant advancements detection treatment, there still long way go before this disease completely eradicated. Therefore, it’s critical find innovative ways diagnose cure conditions. In particular, substantial inertness metallic nanoparticles (NPs) their nanoscale structures, which have sizes comparable many biological molecules, attract great deal biomedical field. Due exceptional optical qualities, chemically modified surface through attachment various ligands, biocompatibility (bio-inertness low cytotoxicity), superior properties, gold NPs (AuNPs) garnered interest. current review discusses efficiency AuNPs fields, including imaging, immunotherapy, photothermal therapy for treating liver cancer. Finally, summarized limitations prospects AuNPs.

Language: Английский

Citations

0
c-FLIP/Ku70 complex; A potential molecular target for apoptosis induction in hepatocellular carcinoma DOI

Yasamin Haghir-Sharif-Zamini,

Arezoo Khosravi, Moustapha Hassan

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110306 - 110306

Published: Jan. 1, 2025

Language: Английский

Citations

0
LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis DOI Creative Commons
Lin Zhu,

Qianqian Meng,

Weiyi Qian

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317454 - e0317454

Published: Jan. 17, 2025

Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and third leading cause of death worldwide. Hepatocellular (HCC) accounts for 75%-85% PHC. LARP3 aberrantly expressed in multiple cancers. We found that it significantly highly liver tissues HCC patients, but exact role specific mechanism this abnormal expression are not yet clear. In study, through bioinformatics analysis, we concluded associated with a poor prognosis patients HCC. Through cellular experiments such as gene editing phenotypic functions, promotes occurrence development inhibits apoptosis. Finally, biological means RNA sequencing, flow cytometry, western blotting, construction subcutaneous tumorigenesis model nude mice, inhibition apoptosis by related to negatively regulating ROS level inhibiting PI3K/c-Fos/apoptosis axis. This study will provide potential targets treatment

Language: Английский

Citations

0