Histopathology of the Intervertebral Disc of Nothobranchius furzeri, a Fish Model of Accelerated Aging DOI Creative Commons
Maria Butylina,

Katharina Wahl‐Figlash,

Michael Kothmayer

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1305 - 1305

Published: Oct. 3, 2023

Introduction: Osteoarthritis is a classical age-related disease, which affects millions of patients worldwide. To further understand the pathophysiology and to develop therapeutic strategies for this animal models play significant role. Nothobranchius furzeri an established model accelerated aging that spontaneously develops spinal deformities. Although bone properties N. are well described, characteristics intervertebral discs still unknown. The aim study was investigate healthy deformed furzeri. Material Methods: Intervertebral were investigated in 8-, 12-, 18- 21.5-week-old male fish GRZ strain. For histological evaluations decalcified, paraffin-embedded stained with (1) hematoxylin eosin, (2) toluidine blue (3) alcian blue/picrosirius red. Results: 8-week-old showed spongy-like tissue containing vacuolated notochord cells beginning formation fibrous central area. Older region peripheral region. Conclusion: Our revealed age- disease-related alterations vertebral Further studies should utility as degenerative spine diseases.

Language: Английский

Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice DOI Creative Commons
Yonggang Fan, Weixin Zhang,

Xiusheng Huang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 5, 2024

Abstract Endplate sclerosis is a notable aspect of spine degeneration or aging, but the mechanisms remain unclear. Here, we report that senescent macrophages accumulate in sclerotic endplates lumbar instability (LSI) aging male mouse model. Specifically, knockout cdkn2a (p16) abrogates LSI aging-induced angiogenesis and endplates. Furthermore, both vivo vitro studies indicate IL-10 primary elevated cytokine senescence-related secretory phenotype (SASP). Mechanistically, increases pSTAT3 endothelial cells, leading to directly binding promoters Vegfa, Mmp2, Pdgfb encourage their production, resulting angiogenesis. This study provides information on understanding link between immune senescence endplate sclerosis, which might be useful for therapeutic approaches.

Language: Английский

Citations

10
Research on the role and mechanism of IL-17 in intervertebral disc degeneration DOI
Bing Peng, Li Qian, Jiangping Chen

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111992 - 111992

Published: April 2, 2024

Language: Английский

Citations

2
Specific plasma biomarker signatures associated with patients undergoing surgery for back pain DOI Creative Commons

Perrine Coquelet,

Sandra Da Cal,

Gilles El Hage

et al.

The Spine Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Back pain in young people: approaches to diagnosis and treatment DOI Creative Commons
Н. А. Шостак, N. G. Pravdyuk, А. В. Новикова

et al.

The Clinician, Journal Year: 2024, Volume and Issue: 17(4), P. 51 - 63

Published: Feb. 29, 2024

Back pain in young people (14–35 years old) may have causes rooted adolescence or even earlier childhood. Diagnosis this case can present considerable difficulties for a therapist and general practitioner, since “nonspecific back pain” hide pathological conditions inherent The degree of compensation scoliosis, hereditary abnormalities the development spine, severity early degenerative processes, metabolic diseases skeleton that were not identified during school determine non-standard scope diagnostic therapeutic measures doctor. These include collecting family history screening patient presence inflammatory according to 2009 ASAS criteria, survey on hospital anxiety depression scale, morphometric assessment stigma dysembryogenesis an hypermobility syndrome, advanced laboratory diagnostics with determination indicators mineral-calcium metabolism, X-ray functional tests, use magnetic resonance imaging computed tomography spine absence radicular symptoms. patient’s active involvement non-drug restorative treatment significantly improves his prognosis, pharmacological support should health-saving direction consider low-intensity inflammation pathogenesis disease. choice therapy reproductively cohort patients is made favor drugs maximum safety profile, which include, among others, selective non-steroidal anti-inflammatory drugs.

Language: Английский

Citations

0
Estudo histológico da morfometria da placa vertebral terminal DOI Creative Commons

Anderson Luís do Nascimento

Published: May 3, 2024

Objetivo: Estudar a placa vertebral terminal em discos sem sinais radiográficos de degeneração, avaliando as características morfométricas dos canais

Citations

0
Genetic factors in the etiology of intervertebral disc herniation and protrusion DOI

А.Н. Федоров,

М.М. Печаткин,

К.В. Вардов

et al.

International journal of medicine and psychology., Journal Year: 2024, Volume and Issue: 7(3), P. 77 - 85

Published: May 18, 2024

грыжи и протрузии межпозвонковых дисков являются распространенными дегенеративными заболеваниями позвоночника, которые приводят к значительному снижению качества жизни пациентов представляют серьезную медико-социальную проблему. В настоящем исследовании проведен комплексный анализ современных научных данных о роли генетических факторов в развитии данной патологии. Рассмотрены ключевые гены-кандидаты, полиморфизмы мутации которых ассоциированы с повышенным риском развития грыж протрузий дисков, а также эпигенетические механизмы регуляции их экспрессии. Особое внимание уделено взаимодействию негенетических этиопатогенезе дегенеративных изменений дисков. Проанализированы перспективы использования достижений молекулярной генетики трансляционной медицины разработке новых подходов диагностике, профилактике лечению Полученные данные свидетельствуют том, что генетические факторы играют важную роль изучение является перспективным направлением для улучшения результатов лечения пациентов. intervertebral disc herniation and protrusion are common degenerative disorders of the spine that lead to a significant decrease in patients' quality life pose serious medical social problem. This study provides comprehensive analysis current scientific data on role genetic factors development this pathology. The key candidate genes, polymorphisms, mutations associated with an increased risk protrusion, as well epigenetic mechanisms regulating their expression, considered. Particular attention is paid interaction non-genetic etiopathogenesis changes discs. prospects for using modern advances molecular genetics translational medicine new approaches diagnosis, prevention, treatment pathology analyzed. obtained indicate play important promising direction improving outcomes life.

Language: Русский

Citations

0
Histopathology of the Intervertebral Disc of Nothobranchius furzeri, a Fish Model of Accelerated Aging DOI Creative Commons
Maria Butylina,

Katharina Wahl‐Figlash,

Michael Kothmayer

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1305 - 1305

Published: Oct. 3, 2023

Introduction: Osteoarthritis is a classical age-related disease, which affects millions of patients worldwide. To further understand the pathophysiology and to develop therapeutic strategies for this animal models play significant role. Nothobranchius furzeri an established model accelerated aging that spontaneously develops spinal deformities. Although bone properties N. are well described, characteristics intervertebral discs still unknown. The aim study was investigate healthy deformed furzeri. Material Methods: Intervertebral were investigated in 8-, 12-, 18- 21.5-week-old male fish GRZ strain. For histological evaluations decalcified, paraffin-embedded stained with (1) hematoxylin eosin, (2) toluidine blue (3) alcian blue/picrosirius red. Results: 8-week-old showed spongy-like tissue containing vacuolated notochord cells beginning formation fibrous central area. Older region peripheral region. Conclusion: Our revealed age- disease-related alterations vertebral Further studies should utility as degenerative spine diseases.

Language: Английский

Citations

1