Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157496 - 157496
Published: Nov. 1, 2024
Language: Английский
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 9, 2024
The rising prevalence of diabetes mellitus has casted a spotlight on one its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for management, are increasingly studied their benefits. These benefits may include reduction oxidative stress and neuroinflammation, decrease amyloid burdens, enhancement neuronal plasticity, improved cerebral glucose utilization. multifaceted effects the relatively favorable side-effect profile SGLT2 inhibitors render them promising therapeutic candidate disorders. Nonetheless, application impairment is not without limitations, necessitating more comprehensive research to fully determine potential treatment. In this review, we discuss role in neural function, elucidate diabetes-cognition nexus, synthesize current knowledge based animal studies clinical evidence. Research gaps proposed spur further investigation.
Language: Английский
Citations
13
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11955 - 11955
Published: Nov. 7, 2024
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.
Language: Английский
Citations
11
Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(S3), P. 31 - 41
Published: July 4, 2024
Abstract Metformin is best known as a foundational therapy for type 2 diabetes but also used in other contexts clinical medicine with number of emerging and potential indications. Many its beneficial effects may be mediated by modest on weight loss insulin sensitivity, it has multiple mechanisms action. Current uses beyond include: polycystic ovarian syndrome; pregnancy/gestational diabetes; prevention prediabetes; adjunct 1 diabetes. As metformin been use almost 70 years, much the underpinning evidence these conditions is, definition, based trials conducted before advent contemporary evidence‐based medicine. result, some above‐established are ‘off‐label’ many regulatory territories their varies accordingly different countries. Going forward, several current ‘repurposing’ investigational being investigated: cancer (including Li Fraumeni syndrome), renal protection, Alzheimer's disease, metabolic dysfunction‐associated steatotic liver disease promotion healthy ageing. Despite longevity important roles medicine, further research ongoing.
Language: Английский
Citations
10
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5929 - 5949
Published: June 13, 2024
Semaglutide (SEM), a glucagon-like peptide-1 receptor agonist, has garnered increasing interest for its potential therapeutic effects in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s (PD). This review provides comprehensive description of SEM’s mechanism action preclinical studies these debilitating conditions. In animal models AD, SEM proved beneficial on multiple pathological hallmarks the disease. administration been associated with reductions amyloid-beta plaque deposition mitigation neuroinflammation. Moreover, treatment shown to ameliorate behavioral deficits related anxiety social interaction. SEM-treated animals exhibit improvements spatial learning memory retention tasks, evidenced by enhanced performance maze navigation tests novel object recognition assays. Similarly, PD, demonstrated promising neuroprotective through various mechanisms. These include modulation neuroinflammation, enhancement mitochondrial function, promotion neurogenesis. Additionally, improve motor function dopaminergic neuronal loss, offering disease-modifying strategies. Overall, accumulating evidence from suggests that holds promise approach AD PD. Further research is warranted elucidate underlying mechanisms translate findings into clinical applications devastating disorders.
Language: Английский
Citations
4
Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)
Published: Feb. 26, 2025
Language: Английский
Citations
0
Journal of Insurance Medicine, Journal Year: 2025, Volume and Issue: 52(1), P. 14 - 20
Published: March 6, 2025
Type 2 diabetes and Alzheimer's dementia represent important health challenges in our society today. Understanding the relationship between these conditions is crucial. This article explores research on whether they share common risk factors or if may influence each other's development, which could lead to more effective prevention treatment strategies.
Language: Английский
Citations
0
Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)
Published: April 1, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1579 - 1579
Published: Dec. 10, 2024
Nervous system diseases represent a significant global burden, affecting approximately 16% of the world’s population and leading to disability mortality. These conditions, encompassing both central nervous (CNS) peripheral (PNS) disorders, have substantial social economic impacts. Metformin, guanidine derivative derived from plant source, exhibits therapeutic properties in various health conditions such as cancer, aging, immune-related polycystic ovary syndrome, cardiovascular ailments, more. Recent studies highlight metformin’s ability cross blood–brain barrier, stimulate neurogenesis, provide beneficial effects specific neurological disorders through diverse mechanisms. This review discusses advancements research on role mechanisms treating within systems, aiming facilitate further investigation, utilization, clinical application metformin neurology.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30909 - e30909
Published: May 1, 2024
Observational studies have found a potential link between the use of thiazolidinediones (TZDs) and lower risk Alzheimer's disease (AD) development. Platelets were great source amyloid-β (Aβ) involved in development AD. This study aimed to assess correlation antidiabetic agents platelet characteristics, hoping provide mechanism TZDs neuroprotection
Language: Английский
Citations
1