Xanthohumol: An underestimated, while potent and promising chemotherapeutic agent in cancer treatment

Progress in Biophysics and Molecular Biology, Journal Year: 2022, Volume and Issue: 172, P. 3 - 14

Published: April 8, 2022

Language: Английский

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Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care

Trends in cancer, Journal Year: 2023, Volume and Issue: 10(3), P. 196 - 207

Published: Nov. 23, 2023

Circadian timekeeping mechanisms and cell cycle regulation share thematic biological principles in responding to signals, repairing cellular damage, coordinating metabolism, allocating resources for optimal function. Recent studies show interactions between regulators circadian clock components, offering insights into potential cancer treatment approaches. Understanding control of metabolism informs timing therapies reduce adverse effects enhance efficacy. adaptability lifestyle factors, such as activity, sleep, nutrition sheds light on their impact cancer. Leveraging regulatory prevention care is vital, most risk stems from modifiable lifestyles. Monitoring factors aids assessment targeted interventions across the continuum.

Language: Английский

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Targeting anticancer immunity in oral cancer: Drugs, products, and nanoparticles

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 116751 - 116751

Published: July 27, 2023

Language: Английский

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Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3980 - 3980

Published: Aug. 5, 2023

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It the most frequently occurring in men and second common women. Due to its frequent diagnosis variable response treatment, lung was reported as top cause cancer-related deaths worldwide 2020. Many aberrant signaling cascades are implicated pathogenesis cancer, including those involved apoptosis (B cell lymphoma protein, Bcl-2-associated X first signal ligand), growth inhibition (tumor suppressor protein or gene serine/threonine kinase 11), promotion (epidermal factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways their molecules have become promising targets for chemopreventive chemotherapeutic agents. Recent research provides compelling evidence use plant-based compounds, known collectively phytochemicals, anticancer This review discusses major contributing pathophysiology well currently available treatments prospective drug candidates. The potential naturally bioactive compounds context also discussed, critical analysis mechanistic actions presented by preclinical clinical studies.

Language: Английский

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Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress

Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154902 - 154902

Published: May 24, 2023

Language: Английский

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