Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(19), P. 5391 - 5429
Published: Jan. 1, 2022
An overview of the key developments in biomaterials as platforms for delivering chemotherapy management retinoblastoma is provided this review.
Language: Английский
Molecules, Journal Year: 2021, Volume and Issue: 26(21), P. 6389 - 6389
Published: Oct. 22, 2021
Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.
Language: Английский
Citations
171
Crystals, Journal Year: 2023, Volume and Issue: 13(11), P. 1576 - 1576
Published: Nov. 8, 2023
Green synthesis offers a superior alternative to traditional methods for producing metal and oxide nanoparticles. This approach is not only benign safe but also cost-effective, scalable, straightforward, operating under ambient conditions. Notable metals nanoparticles, such as manganese oxides, iron silver, gold, have been produced using various bio-reductants derived from plant extracts. These biological agents expedite the reduction process stabilize serving dual roles reducing capping agents. review presents green of nanoparticles (NPs) obtained biogenic wastes The green-synthesized nanostructured MnO2 are evaluated potential photocatalyst water treatment an electrode material in lithium-ion batteries supercapacitors. green-derived examined promising antioxidant, anti-inflammatory, anti-diabetic Additionally, this discusses precious specifically silver (Ag NPs) gold (Au NPs), highlighting their medical applications areas like antiviral treatments cancer therapy.
Language: Английский
Citations
98
International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 195, P. 356 - 383
Published: Dec. 14, 2021
Language: Английский
Citations
100
ChemMedChem, Journal Year: 2022, Volume and Issue: 17(16)
Published: June 22, 2022
Abstract Nanomaterials, that is, materials made up of individual units between 1 and 100 nanometers, have lately involved a lot attention since they offer potential in many fields, including pharmacy biomedicine, owed to their exceptional physicochemical properties arising from high surface area nanoscale size. Smart engineering nanostructures through appropriate or bulk functionalization endows them with multifunctional capabilities, opening new possibilities the biomedical field such as biosensing, drug delivery, imaging, medical implants, cancer treatment tissue engineering. This article highlights up‐to‐date research nanomaterials for applications. A summary different types strategies is provided. Besides, use diagnostic drug/gene regenerative medicine, implants reviewed. Finally, conclusions future perspectives are
Language: Английский
Citations
58
Biosensors, Journal Year: 2022, Volume and Issue: 12(2), P. 93 - 93
Published: Feb. 4, 2022
Nucleic acids are emerging as powerful and functional biomaterials due to their molecular recognition ability, programmability, ease of synthesis chemical modification. Various types nucleic have been used gene regulation tools or therapeutic agents for the treatment human diseases with genetic disorders. can also be develop sensing platforms detecting ions, small molecules, proteins, cells. Their performance improved through integration other organic inorganic nanomaterials. To further enhance biological properties, various chemically modified acid analogues generated by modifying phosphodiester backbone, sugar moiety, nucleobase, combined sites. Alternatively, using building blocks self-assembly highly ordered nanostructures would stability cellular uptake efficiency. In this review, we will focus on development biomedical applications structural natural acids, well over past ten years. The recent progress in nanomaterials based self-assembled DNA-based regulation, biosensing, drug delivery, therapy presented. We then summarize a discussion advanced research, highlight some challenges faced propose suggestions improvement.
Language: Английский
Citations
48
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Aug. 2, 2022
Abstract Ocular drug delivery is one of the most challenging endeavors among various available systems. Despite having suitable drugs for treatment ophthalmic disease, we have not yet succeeded in achieving a proper approach with least adverse effects. Nanotechnology offers great opportunities to overwhelm restrictions common ocular systems, including low therapeutic effects and because invasive surgery or systemic exposure. The present review dedicated highlighting updating recent achievements nano-based technologies disease diagnosis treatment. While further effort remains, progress illustrated here might pave way new very useful nanomedicines.
Language: Английский
Citations
44
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(18), P. 2566 - 2566
Published: Sept. 15, 2023
Cancer is one of the leading causes death worldwide. Because each person’s cancer may be unique, diagnosing and treating challenging. Advances in nanomedicine have made it possible to detect tumors quickly investigate tumor cells at a cellular level contrast prior diagnostic techniques. Quantum dots (QDs) are functional nanoparticles reported useful for diagnosis. QDs semiconducting tiny nanocrystals, 2–10 nm diameter, with exceptional optoelectronic properties that can tailored sensitively report on their environment. This review highlights these synthesis methods when used diagnostics. The conjugation reporting or binding molecules QD surface discussed. summarizes most recent advances using vitro imaging, vivo targeted drug delivery platforms applications.
Language: Английский
Citations
38
BMC Plant Biology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 31, 2024
Abstract Green synthesis is an easy, safe, and environmentally beneficial nanoparticle creation method. It a great challenge to simultaneously improve the capping stabilizing agent carrier separation efficiency of photocatalysts. Herein, Zn-doped Titanium dioxide (TiO 2 ) nanoparticles with high exposure 360 nm using UV/visible spectrophotometer were prepared via one-step hydrothermal decomposition A detailed analysis reveals that electronic structures modulated by Zn doping; thus, responsive wavelength was extended 600 nm, which effectively improved visible light absorption TiO . We have optimized different parameters like concentration, time, temperature. The peak for located at cm- 1 in FTIR. scanning electron microscope revealed has definite shape morphology. synthesized NPs applied against various pathogens study their anti-bacterial potentials. activity shown robust two gram-ve bacteria ( Salmonella Escherichia coli gram + ve Staphylococcus epidermidis aureus ). Synthesized demonstrated strong antifungal efficacy variety fungi. Moreover, doping metal oxide greatly improves characteristics; as result, doped perform better than un-doped nanoparticles. Compared pure , exhibit considerable applications including antimicrobial treatment water purification.
Language: Английский
Citations
14
Journal of Functional Biomaterials, Journal Year: 2021, Volume and Issue: 12(4), P. 75 - 75
Published: Dec. 16, 2021
Breast cancer is becoming one of the main lethal carcinomas in recent era, and its occurrence rate increasing day by day. There are different breast biomarkers, their overexpression takes place metastasis cells. The most prevalent biomarker human epidermal growth factor receptor2 (HER2). As this overexpressed malignant tissues, it has become focus targeted therapies to fight cancer. a cascade mechanisms involved cell proliferation Nanotechnology extremely advanced targeting imaging cancerous Quantum dots (QDs) semiconductor NPs, they used for bioimaging, biolabeling, biosensing. They synthesized approaches such as top-down, bottom-up, synthetic methods. Fully monoclonal antibodies using transgenic mice having immunoglobulin target For HER2 receptor, herceptin® (trastuzumab) specific antibody (Ab), conjugated with QDs types coupling mechanisms. This quantum dot (QD-mAb) conjugate localized injecting into blood vessel. After injection, goes through series steps reach intracellular space, bioimaging specifically receptor occurs, where apoptosis cells either liberation Ab or free radicals.
Language: Английский
Citations
51
Nanomaterials, Journal Year: 2021, Volume and Issue: 11(12), P. 3330 - 3330
Published: Dec. 8, 2021
In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on other hand, have limitations that make detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors revolutionized era of treatment targeted action via attaching specified biocompatible ligands to target tissues, which are highly over-expressed in certain types cancers. Advancements NPs can be achieved modifying molecular genetics develop personalized treatments based RNA interference. Modification therapies utilized small subunits form interfering RNAs (siRNA) overexpressing specific genes of, most commonly, breast, colon, gastric, cervical, hepatocellular cancer. RNA-conjugated nanomaterials appear gold standard preventing various malignant tumors through focused delivering a tissue, resulting cells going into programmed death. The latest advances nanotechnology applications summarized this review.
Language: Английский
Citations
42