Coatings,
Journal Year:
2022,
Volume and Issue:
12(4), P. 460 - 460
Published: March 28, 2022
Biosynthesis
of
gold
nanoparticles
from
medicinal
plants
has
become
a
modern
strategy
in
biomedical
research
based
on
their
exclusive
properties,
including
specific
targeting,
lower
toxicity,
and
biocompatibility.
In
this
study,
nanoparticles,
reduced
by
the
Suaeda
japonica
leaf
extract,
were
promptly
validated
UV–visible
(UV–Vis)
spectroscopy
at
548
nm.
No
additional
reducing
agents
needed
kind
reduction
reaction,
which
provided
evidence
green
synthesis.
Dynamic
light
scattering
(DLS),
energy-dispersive
X-ray
(EDX),
field-emission
transmission
electron
microscopy
(FE-TEM),
selected
area
diffraction
(SAED),
(XRD)
analyses
used
to
illustrate
nanoscale
characterization
S.
(Sj-AuNps).
Furthermore,
cytotoxicity
effect
Sj-AuNps
against
RAW
264.7
cell
line
was
determined
performing
an
MTT
assay.
We
also
investigated
Sj-AuNps’
anti-inflammatory
properties
LPS-induced
murine
macrophages.
These
generation
nitric
oxide
(NO)
prostaglandin
E2
(PGE2)
repressed
expression
LPS-stimulated
inducible
synthase
(iNOS)
cyclooxygenase-2
(COX-2)
genes.
This
study
presents
significant
application
AuNps.
The
capabilities
underline
potential
as
possible
options
for
suppressing
inflammation-mediated
diseases.
International Journal of Nanomedicine,
Journal Year:
2022,
Volume and Issue:
Volume 17, P. 3735 - 3749
Published: Aug. 1, 2022
Abstract:
Cancer
remains
the
most
devastating
disease
and
major
cause
of
mortality
worldwide.
Although
early
diagnosis
treatment
are
key
approach
in
fighting
against
cancer,
available
conventional
diagnostic
therapeutic
methods
not
efficient.
Besides,
ineffective
cancer
cell
selectivity
toxicity
traditional
chemotherapy
remain
significant
challenge.
These
limitations
entail
need
for
development
both
safe
effective
options.
Due
to
its
robust
application,
nanotechnology
could
be
a
promising
method
in-vivo
imaging
detection
cells
biomarkers.
Nanotechnology
provide
quick,
safe,
cost-effective,
efficient
management.
It
also
provides
simultaneous
using
nano-theragnostic
particles
that
facilitate
selective
destruction
cells.
Updated
recent
discussions
important
selecting
best
diagnosis,
treatment,
management
options,
new
insights
on
designing
protocols
utmost
important.
This
review
discusses
application
therapeutics,
theragnosis
future
perspectives
field.
Keywords:
nanotechnology,
theragnostics
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(6), P. 2115 - 2176
Published: May 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Heliyon,
Journal Year:
2022,
Volume and Issue:
8(5), P. e09403 - e09403
Published: May 1, 2022
Investigators
were
continuously
creating
novel
nanotechnologies
to
address
unmet
requirements
throughout
the
administration
of
therapeutic
medicines
&
imaging
agents
for
cancer
treatment
diagnostics,
appropriately.
LNPs(Lipid
nanoparticles)
are
legitimate
particulates
(approx.
100
nm
in
size)
gathered
from
various
lipid
as
well
other
biochemical
compounds
which
overall
functionality
resolve
biological
barriers
(biobarriers),
allowing
LNPs
selectively
collect
somewhere
outside
disease-target
cells
again
responsive
therapeutics.
Most
pharmaceutically
important
insoluble
water
solutions,
chemical
physiologically
unstable,
or
have
toxicities.
Among
most
potential
drug
carrier
bioactive
organic
is
LBNPs
(Lipid
based
technologies.
Its
present
use
chemotherapy
transformed
by
increasing
antitumor
effect
a
number
chemotherapeutics.
Because
they
may
be
created
using
naturally
occurring
sources,
great
temporal
and
thermal
stability,
maximum
load
potential,
simplicity
preparations,
cheap
manufacturing
costs,
big
output.
Furthermore,
combining
chemotherapeutic
drugs
with
reduces
active
dosage
toxicities,
lowers
resistance,
raises
concentration
tumour
while
reducing
concentrations
normal
tissue.
widely
studied
treatment,
both
vitro
vivo,
encouraging
outcomes
certain
clinical
trials.
This
study
provides
an
overview
many
types
been
latest
years
their
applications
contributions
different
cancers.
Advances in Colloid and Interface Science,
Journal Year:
2023,
Volume and Issue:
322, P. 103035 - 103035
Published: Nov. 3, 2023
Surface-functionalized
nanostructures
are
at
the
forefront
of
biotechnology,
providing
new
opportunities
for
biosensors,
drug
delivery,
therapy,
and
bioimaging
applications.
The
modification
significantly
impacts
performance
success
various
applications
by
enabling
selective
precise
targeting.
This
review
elucidates
widely
practiced
surface
strategies,
including
click
chemistry,
cross-coupling,
silanization,
aldehyde
linkers,
active
ester
maleimide
epoxy
other
protein
DNA-based
methodologies.
We
also
delve
into
application-focused
landscape
nano-bio
interface,
emphasizing
four
key
domains:
therapeutics,
biosensing,
environmental
monitoring,
point-of-care
technologies,
highlighting
prominent
studies.
insights
presented
herein
pave
way
further
innovations
intersection
nanotechnology
a
useful
handbook
beginners
professionals.
draws
on
sources,
latest
research
articles
(2018-2023),
to
provide
comprehensive
overview
field.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
180, P. 1 - 17
Published: April 10, 2024
This
analysis
explores
the
principal
regulatory
concerns
linked
to
nanomedicines
and
gene
vaccines,
including
complexities
involved
perspectives
on
how
navigate
them.
In
realm
of
nanomedicines,
ensuring
safety
nanomaterials
is
paramount
due
their
unique
characteristics
potential
interactions
with
biological
systems.
Regulatory
bodies
are
actively
formulating
guidelines
standards
assess
risks
associated
nanomedicine
products,
emphasizing
need
for
standardized
characterization
techniques
accurately
gauge
effectiveness.
Regarding
frameworks
must
be
tailored
address
distinct
challenges
posed
by
genetic
interventions,
necessitating
special
considerations
in
efficacy
evaluations,
particularly
concerning
vector
design,
target
specificity,
long-term
patient
monitoring.
Ethical
such
as
autonomy,
informed
consent,
privacy
also
demand
careful
attention,
alongside
intricate
matter
intellectual
property
rights,
which
balanced
against
imperative
widespread
access
these
life-saving
treatments.
Collaborative
efforts
among
bodies,
researchers,
patent
offices,
private
sector
essential
tackle
effectively,
international
cooperation
being
especially
crucial
given
global
scope
vaccine
development.
Striking
right
balance
between
safeguarding
properties
promoting
public
health
vital
fostering
innovation
equitable
ground-breaking
technologies,
underscoring
significance
addressing
hurdles
fully
harness
benefits
vaccines
enhancing
healthcare
outcomes
a
scale.
STATEMENT
OF
SIGNIFICANCE:
Several
biomaterials
proposed
development
nanovaccines,
from
polymeric
micelles,
PLGA-/PEI-/PLL-nanoparticles,
solid
lipid
nananoparticles,
cationic
lipoplexes,
liposomes,
hybrid
materials,
dendrimers,
carbon
nanotubes,
hydrogels,
quantum
dots.
Lipid
nanoparticles
(LNPs)
have
gained
tremendous
attention
since
US
Food
Drug
Administration
(FDA)
approval
Pfizer
Moderna's
COVID-19
raising
awareness
vaccines.
review
provides
insights
into
current
strategies
issues,
clinical
trials.
By
navigating
landscapes
we
can
unlock
full
using
range
promising
towards
improving
worldwide.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
17, P. 100441 - 100441
Published: Sept. 26, 2022
Thyroid
cancer,
as
one
of
the
most
common
endocrine
cancers,
has
seen
a
surge
in
incidence
recent
years.
This
is
likely
due
to
lack
specificity
and
accuracy
its
traditional
diagnostic
modalities,
leading
overdiagnosis
thyroid
nodules.
Although
there
are
several
treatment
options
available,
they
limited
surgery
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 22, 2023
Breast
cancer
(BC)
is
the
most
frequently
diagnosed
malignant
tumor
among
women
in
world.
BC
heterogeneous
with
different
subtypes
including
luminal
A-like,
B-like
(HER2-/HER2+),
HER2
enriched,
and
triple-negative
BC.
The
therapeutic
strategies
surgery,
chemotherapy,
radiotherapy,
targeted
therapy,
endocrine
therapy
are
well
developed
commonly
used
treatment
of
However,
some
adverse
effects
these
conventional
treatments
limited
their
wide
application
clinical.
Therefore,
it
necessary
to
develop
more
safe
efficient
individualized
Nanomedicine,
as
promising
strategy
for
controlled
drug
delivery,
widely
multiple
aspects
therapy.
Importantly,
accumulative
evidences
show
that
nanomedicine
has
achieved
good
outcomes
a
huge
amount
patients
benefited
from
related
treatments.
In
this
review,
we
summarized
discussed
major
problems
occurred
during
administration
potential
roles
promoting
efficacy
by
overcoming
obstacles
current
Microsystems & Nanoengineering,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Nov. 17, 2023
Biomedical
investigations
in
nanotherapeutics
and
nanomedicine
have
recently
intensified
pursuit
of
new
therapies
with
improved
efficacy.
Quantum
dots
(QDs)
are
promising
nanomaterials
that
possess
a
wide
array
advantageous
properties,
including
electronic
optical
engineered
biocompatibility
under
physiological
conditions.
Due
to
these
characteristics,
QDs
mainly
used
for
biomedical
labeling
theranostic
(therapeutic-diagnostic)
agents.
can
be
functionalized
ligands
facilitate
their
interaction
the
immune
system,
specific
IgE,
effector
cell
receptors.
However,
undesirable
side
effects
such
as
hypersensitivity
toxicity
may
occur,
requiring
further
assessment.
This
review
systematically
summarizes
potential
uses
allergy
field.
An
overview
definition
development
is
provided,
along
applications
studies,
detection
allergen-specific
IgE
(sIgE),
food
allergens,
sIgE
cellular
tests.
The
treatment
allergies
also
described,
highlighting
nanodevices.
Finally,
we
discuss
current
findings
on
immunotoxicity
QDs.
Several
favorable
points
regarding
use
diagnosis
noted.
