Electrochemically selective detection of dopamine over serotonin by CuO/Cu2O bulk heterostructure electrode

Bulletin of Materials Science, Journal Year: 2024, Volume and Issue: 47(2)

Published: March 23, 2024

Language: Английский

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Electrochemical Detection of Dopamine with a Non-Enzymatic Sensor Based on Au@SiO2-APTES Composite

Chemosensors, Journal Year: 2025, Volume and Issue: 13(3), P. 87 - 87

Published: March 3, 2025

A novel material composed of Au@SiO2-(3-Aminopropyl Triethoxysilane) (Au@SiO2-APTES) was successfully synthesised using the sol–gel method, and used to modify glassy carbon electrodes. Its effectiveness as a molecular recognition element is evaluated in design an electrochemical sensor for precise detection dopamine. The Au@SiO2-APTES composite analysed Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray diffraction. Elemental analysis verified presence oxygen, silicon, gold, with atomic percentages around 77.19%, 21.12%, 1.65%, respectively. corresponding elemental mapping showed that spatial distribution all elements fairly homogeneous throughout composite, indicating Au NPs are embedded silica structures. Traces dopamine were detected by differential pulse voltammetry low limit (S/N = 3) quantification 10) 1.4 × 10−8 molL−1 4.7 molL−1, had two linear ranges: from 1 10−7 1.25 8.75 molL−1. Moreover, outstanding selectivity even various potential interfering species. It also demonstrated good reusability signal recovery when tested human urine plasma samples spiked different concentrations. sensor, constructed this material, shows great promise selective sensitive biological matrix. These results underscore sensor’s capability practical application analysing real-world samples.

Language: Английский

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Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 24, 2022

Detecting physiological levels of neurotransmitters in biological samples can advance our understanding brain disorders and lead to improved diagnostics therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations target analytes from small volume working samples. Herein, a platform robust ultrasensitive detection dopamine, an essential that underlies several disorders, based on graphene multitransistor arrays (gMTAs) functionalized with selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed integrate multiple transistors small-size chips (4.5 × 4.5 mm). The sensor array configuration permits independent simultaneous replicate measurements same sample produce average data, reducing sources measurement variability. This procedure allowed sensitive reproducible dopamine ultra-low across buffers high ionic strength complex obtained limit-of-detection was 1 aM (10-18) dynamic ranges spanning 10 orders magnitude up 100 µM (10-8), 22 mV/decade peak sensitivity artificial cerebral spinal fluid. Dopamine dopamine-depleted homogenates spiked also possible LOD aM, overcoming losses typically observed ion-sensitive Furthermore, we show gMTAs minimal changes (2 µL) fluid mouse model Parkinson's Disease. presented this work way graphene-based suitable academic pre-clinical pharmaceutical research as well clinical diagnosis.

Language: Английский

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Functional graphitic carbon (IV) nitride: A versatile sensing material

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 466, P. 214611 - 214611

Published: May 13, 2022

Language: Английский

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Biosensors: Electrochemical Devices—General Concepts and Performance

Biosensors, Journal Year: 2022, Volume and Issue: 13(1), P. 44 - 44

Published: Dec. 28, 2022

This review provides a general overview of different biosensors, mostly concentrating on electrochemical analytical devices, while briefly explaining approaches to various kinds their construction and performance. A discussion how all required components biosensors are brought together perform work is offered. Different signal-transducing mechanisms discussed, particularly addressing the immobilization biomolecular in vicinity transducer interface functional integration with electronic devices. The concepts biosensing processes rather than specific modern achievements area.

Language: Английский

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Rapid and selective detection of dopamine in human serum using an electrochemical sensor based on zinc oxide nanoparticles, nickel phthalocyanines, and carbon nanotubes

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 210, P. 114211 - 114211

Published: March 31, 2022

Language: Английский

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Flexible electrode based on nitrogen carbon quantum dots for dopamine detection

Applied Surface Science, Journal Year: 2023, Volume and Issue: 626, P. 157241 - 157241

Published: April 11, 2023

Language: Английский

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A simple preparation of N-doped reduced graphene oxide as an electrode material for the detection of hydrogen peroxide and glucose

Electrochimica Acta, Journal Year: 2023, Volume and Issue: 446, P. 142113 - 142113

Published: Feb. 27, 2023

Language: Английский

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From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 806 - 806

Published: Aug. 11, 2023

Neurotransmitters are an important category of substances used inside the nervous system, whose detection with biosensors has been seriously addressed in last decades. Dopamine, a neurotransmitter from catecholamine family, was recently discovered to have implications for cardiac arrest or muscle contractions. In addition having many other neuro-psychiatric implications, dopamine can be detected blood, urine, and sweat. This review highlights importance as influential tools recognition. The first part this article is related introduction neurotransmitters, focus on dopamine. regular methods their expensive require high expertise personnel. A major direction evolution these expanded integration active biological materials suitable molecular recognition near electronic devices. Secondly, particular, miniaturized offer excellent sensitivity specificity cheaper than conventional spectrometry, while linear ranges years fall exactly clinical intervals. Thirdly, applications novel nanomaterials biomaterials discussed. Older generations, metabolism-based enzymatic biosensors, could not detect concentrations below micro-molar range. But new generations combine aptamer receptors organic electrochemical transistors, OECTs, transducers. They pushed limit pico-molar even femto-molar ranges, which fully correspond usual human body humors that cover 0.1 ÷ 10 nM. addition, if ten ago use natural cell membranes seemed impossible actual technology allows co-integrate transistors vesicles dopamine, like G protein-coupled receptors. still complicated, but uni-molecular selectivity promising.

Language: Английский

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Advanced functional materials for electrochemical dopamine sensors

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 169, P. 117367 - 117367

Published: Oct. 12, 2023

Language: Английский

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