Journal of Innate Immunity,
Journal Year:
2024,
Volume and Issue:
16(1), P. 513 - 528
Published: Oct. 15, 2024
Introduction:
Escherichia
coli
(E.
coli)
is
a
significant
commensal
gram-negative
bacterium
that
can
give
rise
to
various
diseases.
The
roles
of
Toll-like
receptor
2
(TLR2)
and
the
NOD-like
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
in
sepsis
induced
by
E.
infection
remain
unclear.
Methods:
In
vivo,
we
investigated
differences
mortality,
production
inflammatory
mediators,
organ
damage,
neutrophil
count,
bacterial
load
during
C57BL/6J
mice,
as
well
mice
deficient
TLR2
or
NLRP3.
vitro,
impact
on
activation
NLRP3
macrophages
influence
signaling
pathways
secretion
mediators
infection.
Results:
TLR2-deficient
(TLR2−/−)
NLRP3-deficient
(NLRP3−/−)
exhibit
significantly
increased
mortality
damage
after
These
also
show
elevated
levels
TNF-α
IL-10
serum
peritoneal
lavage
fluid.
Additionally,
TLR2−/−
NLRP3−/−
display
heightened
recruitment
blood.
Furthermore,
from
these
demonstrate
reduction
MAPK
pathway.
Conclusion:
play
crucial
modulating
mediator
expression,
immune
cell
recruitment,
bactericidal
activity,
thereby
preventing
excessive
tissue
reducing
coli-induced
sepsis.
Future Science OA,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Feb. 20, 2025
This
review
explores
the
potential
of
polymeric
nanoparticles
(PNPs)
as
targeted
drug
delivery
systems
for
arthritic
treatment,
overcoming
limitations
present
therapy.
A
thorough
literature
search
was
conducted
on
databases
PubMed,
Scopus,
and
Web
Science
to
find
published
articles
use
in
treatment
arthritis.
includes
synthesis
methods,
mechanisms
delivery,
applications
PNPs.
Polymeric
showed
excellent
promise
management
arthritis
through
enhanced
stability
drugs,
controlled
sustained
release,
reduced
systemic
side
effects.
Some
highlighted
biocompatible
targeting
capabilities
natural
synthetic
polymers
include
chitosan,
hyaluronic
acid,
PLGA.
Bioactive
compounds
such
curcumin
resveratrol
delivered
by
PNPs
therapeutic
efficacy
preclinical
models.
Despite
their
promise,
challenges
rapid
clearance
manufacturing
scalability
remain
critical
barriers.
offer
a
transformative
approach
enabling
targeted,
sustained,
safe
delivery.
Translation
into
clinical
would
thus
require
developments
nanoparticle
design,
personalized
medicine,
scalable
production
techniques.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7603 - 7603
Published: July 11, 2024
This
article
presents
a
groundbreaking
perspective
on
carotenoids,
focusing
their
innovative
applications
and
transformative
potential
in
human
health
medicine.
Research
jointly
delves
deeper
into
the
bioactivity
bioavailability
of
revealing
therapeutic
uses
technological
advances
that
have
to
revolutionize
medical
treatments.
We
explore
pioneering
which
carotenoids
are
used
treat
chronic
diseases
such
as
cancer,
cardiovascular
disease,
age-related
macular
degeneration,
offering
novel
protective
mechanisms
benefits.
Our
study
also
shows
cutting-edge
innovations
carotenoid
extraction
bioavailability,
including
development
supramolecular
carriers
advanced
nanotechnology,
dramatically
improve
absorption
efficacy
these
compounds.
These
not
only
ensure
consistent
quality
but
tailor
therapies
each
patient's
needs,
paving
way
for
personalized
By
integrating
latest
scientific
discoveries
techniques,
this
research
provides
prospective
clinical
establishing
new
benchmark
future
studies
field.
findings
underscore
importance
optimizing
extraction,
administration,
bioactivity,
methods
develop
more
effective,
targeted,
treatments,
thus
visionary
insight
modern
practices.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2657 - 2657
Published: Aug. 11, 2024
Irritable
bowel
syndrome
(IBS)
is
a
prevalent
functional
gastrointestinal
disorder
characterized
by
abdominal
pain,
bloating,
diarrhea,
and
constipation.
Recent
studies
have
underscored
the
significant
role
of
gut
microbiota
in
pathogenesis
IBS.
Physical
exercise,
as
non-pharmacological
intervention,
has
been
proposed
to
alleviate
IBS
symptoms
modulating
microbiota.
Aerobic
such
running,
swimming,
cycling,
shown
enhance
diversity
abundance
beneficial
bacteria,
including
Lactobacillus
Bifidobacterium.
These
bacteria
produce
short-chain
fatty
acids
that
possess
anti-inflammatory
properties
support
barrier
integrity.
Studies
involving
patients
participating
structured
aerobic
exercise
programs
reported
improvements
their
microbiota's
composition
diversity,
alongside
an
alleviation
like
pain
bloating.
Additionally,
positively
influences
mental
health
reducing
stress
improving
mood,
which
can
further
relieve
via
gut-brain
axis.
Long-term
interventions
provide
sustained
benefits,
maintaining
stability,
supporting
immune
functions,
systemic
inflammation.
However,
must
be
tailored
individual
needs
avoid
exacerbating
symptoms.
Personalized
plans
starting
with
low-to-moderate
intensity
gradually
increasing
maximize
benefits
minimize
risks.
This
review
examines
impact
various
types
intensities
physical
on
patients,
highlighting
need
for
explore
optimal
protocols.
Future
research
should
include
larger
sample
sizes,
longer
follow-up
periods,
examine
synergistic
effects
other
lifestyle
modifications.
Integrating
into
comprehensive
management
symptom
control
improve
patients'
quality
life.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(4), P. 2007 - 2022
Published: Feb. 19, 2024
Abstract
This
review
highlights
the
increasing
interest
in
one
of
natural
compounds
called
saponins,
for
their
potential
therapeutic
applications
addressing
inflammation
which
is
a
key
factor
various
chronic
diseases.
It
delves
into
molecular
mechanisms
responsible
anti‐inflammatory
effects
these
amphiphilic
compounds,
prevalent
plant‐based
foods
and
marine
organisms.
Their
structures
vary
with
soap‐like
properties
influencing
historical
uses
traditional
medicine
sparking
renewed
scientific
interest.
Recent
research
focuses
on
inflammatory
diseases,
unveiling
actions
such
as
NF‐κB
MAPK
pathway
regulation
COX/LOX
enzyme
inhibition.
Saponin‐containing
sources
like
Panax
ginseng
soybeans
suggest
novel
therapies.
The
explores
emerging
role
shaping
gut
microbiome,
composition
activity,
contributing
to
effects.
Specific
examples,
notoginseng
Gynostemma
pentaphyllum
,
illustrate
intricate
relationship
between
collective
impact
immune
metabolic
health.
Despite
promising
findings,
emphasizes
need
further
comprehend
behind
interactions
underscoring
crucial
balanced
microbiome
optimal
health
positioning
saponins
dietary
interventions
managing
conditions.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(6), P. 872 - 872
Published: March 17, 2024
Dietary
supplements
enriched
with
bioactive
compounds
represent
a
promising
approach
to
influence
physiological
processes
and
enhance
longevity
overall
health.
Cynara
cardunculus
var.
scolymus
serves
as
functional
food
supplement
high
concentration
of
compounds,
which
offers
various
health-promoting
benefits.
Several
chronic
diseases
have
metabolic,
genetic,
or
inflammatory
origins,
are
frequently
interconnected.
Pharmacological
treatments,
although
effective,
often
result
in
undesirable
side
effects.
In
this
context,
preventive
approaches
gaining
increased
attention.
Recent
literature
indicates
that
the
consumption
diet
can
positively
organism’s
biological
functions.
Polyphenols,
well-known
for
their
health
benefits,
widely
recognized
valuable
preventing/combating
pathologies
related
lifestyle,
metabolism,
aging.
The
C.
belonging
Asteraceae
family,
is
used
herbal
medicine
fields
its
beneficial
properties.
Although
inflorescences
(capitula)
artichoke
culinary
purposes,
preparations
based
on
leaves
be
an
active
ingredient
medicines.
shows
potential
benefits
different
domains.
Its
nutritional
value
make
it
candidate
improving
well-being.
exhibits
anti-inflammatory,
antioxidant,
liver-protective,
bile-expelling,
antimicrobial,
lipid-lowering
neuroprotective
Different
studies
demonstrate
oxidative
stress
leading
cause
onset
progression
major
human
disorders
such
cardiovascular,
neurological,
cancer
diseases.
large
amount
polyphenol
found
has
antioxidant
activity,
enabling
neutralize
free
radicals,
preventing
cellular
damage.
This
reduces
subsequent
risk
developing
conditions
cancer,
diabetes,
cardiovascular
Additionally,
these
polyphenols
anti-inflammatory
closely
associated
As
result,
contribute
treatment
diseases,
including
intestinal
disorders,
neurodegenerative
pathologies.
current
review
discussed
profiles,
pharmacological
effects
scolymus.
