Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 971 - 1012

Published: Feb. 28, 2022

Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup resistances. However, significant technological advancements have been made in terms superior modes delivery over the last few decades. Technical capability analyzing molecular mechanisms tumor biology, nanotechnology─particularly development biocompatible nanoparticles, surface modification techniques, microelectronics, material sciences─has increased. As a result, number nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency developed. This particular maneuver enables introduction substance body by controlling rate, time, place is defined system (NDDS). Because their versatility ability incorporate features water solubility, stability, biocompatibility, degradability, reverse resistance, they attracted interest scientific community, general, nanotechnologists well biomedical scientists. To keep pace rapid advancement nanotechnology, technical aspects recent NDDSs prospects need be reported coherently. address these ongoing issues, this review article provides an overview different lipids, polymers, inorganic nanoparticles. In addition, also reports challenges current points out prospective research directions nanocarriers. From our focused review, we conclude still now most advanced potent field application lipid-based, while significantly potential fields include polymer-based NDDSs. despite promises, remain practical implementations dosage caution should exercised regarding biocompatibility materials. Considering objectively, on will particularly small-to-large scale industrial researchers academicians expertise delivery, research, nanotechnology.

Language: Английский

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An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment

Cancers, Journal Year: 2022, Volume and Issue: 14(12), P. 2868 - 2868

Published: June 10, 2022

The enhanced permeability and retention (EPR) effect in cancer treatment is one of the key mechanisms that enables drug accumulation at tumor site. However, despite a plethora virus/inorganic/organic-based nanocarriers designed to rely on EPR effectively target tumors, most have failed clinic. It seems non-compliance research activities with clinical trials, goals unrelated effect, lack awareness impact solid structure interactions performance intensified this dissatisfaction. As such, asymmetric growth structural complexity physicochemical properties nanocarriers, analytical combination tools, description should be considered improve EPR-based therapeutics. This review provides valuable insights into limitations therapeutic efficacy reports crucial perspectives how can modulated effects nanomedicine.

Language: Английский

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Exploring metal-organic frameworks (MOFs) in drug delivery: A concise overview of synthesis approaches, versatile applications, and current challenges

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102443 - 102443

Published: Sept. 21, 2024

Language: Английский

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Cervical cancer: Novel treatment strategies offer renewed optimism

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155136 - 155136

Published: Jan. 15, 2024

Language: Английский

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Targeting triple negative breast cancer stem cells using nanocarriers

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Language: Английский

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Formulation of Quaternized Aminated Chitosan Nanoparticles for Efficient Encapsulation and Slow Release of Curcumin

Molecules, Journal Year: 2021, Volume and Issue: 26(2), P. 449 - 449

Published: Jan. 16, 2021

An effective drug nanocarrier was developed on the basis of a quaternized aminated chitosan (Q-AmCs) derivative for efficient encapsulation and slow release curcumin (Cur)-drug. A simple ionic gelation method conducted to formulate Q-AmCs nanoparticles (NPs), using different ratios sodium tripolyphosphate (TPP) as an crosslinker. Various characterization tools were employed investigate structure, surface morphology, thermal properties formulated nanoparticles. The NPs displayed smaller particle size 162 ± 9.10 nm, higher positive charges, with maximum potential +48.3 mV, compared native (AmCs) (231 7.14 +32.8 mV). Cur-drug efficiency greatly improved reached value 94.4 0.91%, 75.0 1.13% AmCs NPs. Moreover, in vitro Cur-release profile investigated under conditions simulated gastric fluid [SGF; pH 1.2] colon [SCF; 7.4]. For NPs, rate meaningfully decreased, recorded cumulative 54.0% at 7.4, 73.0% exhibited acceptable biocompatibility biodegradability. These findings emphasize that have outstanding delivery anticancer drugs.

Language: Английский

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Nano-traditional Chinese medicine: a promising strategy and its recent advances

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(16), P. 2973 - 2994

Published: Jan. 1, 2022

Traditional Chinese Medicine (TCM) has been applied to the prevention and treatment of numerous diseases an irreplaceable role in rehabilitation health care. However, application TCMs is drastically limited by their defects, such as single administration, poor water solubility, low bioavailability, weak targeting capability. Recently, nanoparticles have extensively used resolving pharmaceutical obstacles consideration large specific surface area, strong capability, good sustained-release effect, etc. In this review, we first describe limitations TCM ingredients two significant forms nanotechnology TCM, nanometerization nano-drug delivery systems for TCMs. Then, discuss preparation methods nanometerization: mechanical crushing, spray drying, high-pressure homogenization, which utilized conquer various weaknesses recent advances are discussed, including lipid-based nanocarriers, polymeric nanoparticles, inorganic hybrid self-assembled nanoparticles. Finally, future challenges perspectives formula complexity nanocarriers also discussed. Better understanding function will help modernize medicine broaden nano-TCM clinic.

Language: Английский

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A systemic review on development of mesoporous nanoparticles as a vehicle for transdermal drug delivery

Nanotheranostics, Journal Year: 2022, Volume and Issue: 7(1), P. 70 - 89

Published: Nov. 23, 2022

Recent advances in drug delivery technologies utilizing a variety of carriers have resulted paradigm shift the current approach to diagnosis and therapy. Mesoporous silica nanoparticles (MSNs) were developed response need for materials with high thermal, chemical, mechanical properties. The synthesis, ease surface functionalization, tunable pore size, large area, biocompatibility MSNs make them useful biomedical applications such as delivery, theranostics, stem cell research. In addition, capability delivering actives ranging from small molecules drugs amino acids larger peptides, vaccines, antibodies general. Moreover, MSN-based transdermal has sparked lot interest because increase stability, permeation, functionalization. functionalization plays an important role efficient therapeutic agents highly controlled manner. This review introduced dermal systems, explained anatomy skin, summarized different barriers that affect many agents. fundamentals together their physicochemical properties, synthesis approaches, raw used fabrication, factors affecting properties will be covered. terms toxicity safety, biodistribution help detailed literature review. is covering future perspectives pharmaceutical field applications.

Language: Английский

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Recent updates on innovative approaches to overcome drug resistance for better outcomes in cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 346, P. 43 - 70

Published: April 9, 2022

Language: Английский

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Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1), P. 1 - 18

Published: Jan. 3, 2023

Cancer is a very heterogeneous disease, and uncontrolled cell division the main characteristic of cancer. Cancerous cells need high nutrition intake to enable aberrant growth survival. To do so, cancer modify metabolic pathways produce energy anabolic precursors preserve redox balance. Due importance in tumor malignant transformation, have also been given promising perspectives for treatment, providing more effective treatment strategies, target-specific with minimum side effects. Metabolism-based therapeutic nanomaterials targeted are option. Numerous types nanoparticles (NPs) employed research analysis various therapies. The current review focuses on cutting-edge strategies therapy methods based that target metabolisms. Additionally, it highlighted primacy NPs-based therapies over traditional ones, challenges, future potential.

Language: Английский

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