Near-infrared photoimmunotherapy and anti-cancer immunity DOI Open Access
Kohei Nakajima, Mikako Ogawa

International Immunology, Journal Year: 2023, Volume and Issue: 36(2), P. 57 - 64

Published: Oct. 16, 2023

Abstract The activation of the anti-cancer immune system is an important strategy to control cancer. A new form cancer phototherapy, near-infrared photoimmunotherapy (NIR-PIT), was approved for clinical use in 2020 and uses IRDye® 700DX (IR700)-conjugated antibodies NIR light. After irradiation with light, antibody–IR700 conjugate forms water-insoluble aggregations on plasma membrane target cells. This aggregation causes lethal damage membrane, effectively leads immunogenic cell death (ICD). Subsequently, ICD activates cells such as dendritic cytotoxic T Combination therapy immune-checkpoint blockade has synergistically improved effects NIR-PIT. Additionally, NIR-PIT can eliminate immunosuppressive light-irradiated tumors by using specific against regulatory myeloid-derived suppressor In addition cancer-cell-targeted NIR-PIT, immune-cell-targeted shown promising results activating system. Furthermore, be used manipulate tumor microenvironment eliminating only targeted tumor, thus it also gain insight into immunity basic research.

Language: Английский

Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy DOI Creative Commons

Shuyan He,

Lu Zheng,

Chunjian Qi

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

Language: Английский

Citations

2
EGFR-Targeted Photodynamic Therapy DOI Creative Commons
Luca Ulfo, Paolo Emidio Costantini, Matteo Di Giosia

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 241 - 241

Published: Jan. 20, 2022

The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and metastatization of cancer cells. Aberrancies expression activation EGFR are hallmarks many human malignancies. As such, EGFR-targeted therapies hold significant potential for cure cancers. In recent years, photodynamic therapy (PDT) has gained increased interest as non-invasive treatment. PDT, photosensitizer is excited by light to produce reactive oxygen species, resulting local cytotoxicity. One critical aspects PDT selectively transport enough photosensitizers tumors environment. Accordingly, an increasing number strategies have been devised foster PDT. Herein, we review nanobiotechnological advancements that combine promise with molecular therapy. We recapitulate chemistry sensitizers their modes action summarize advantages pitfalls different targeting moieties, highlighting future perspectives treatment cancer.

Language: Английский

Citations

66
Dual-Emitter Graphene Glass Fiber Fabric for Radiant Heating DOI
Hao Yuan, Hui Zhang, Kewen Huang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2577 - 2584

Published: Feb. 2, 2022

Radiant heating, as a significant thermal management technique, is best known for its high effect, media-free operation, good penetration, and compatibility different heated shapes. To promote sustainable development in this area, developing advanced infrared radiation material demand. In work, lightweight, flexible dual-emitter electrothermal material, graphene glass fiber (GGF), developed by chemical vapor deposition (CVD) method, with both the elements. Large-area GGF fabric (GGFF) exhibits wavelength-independent emissivity (0.92) efficiency (79.4%), well ultrafast response (190.7 °C s-1 at 9.30 W cm-2) uniform heating temperature. The superior radiant capability of GGFF to traditional alloy wires can achieve 33.3% energy saving. efficient energy-saving heat technology.

Language: Английский

Citations

52
High‐Entropy Engineering for Broadband Infrared Radiation DOI
Weiming Wang, Baohua Liu, Cheng‐Yu He

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(43)

Published: July 4, 2023

Abstract Developing high‐performance infrared (IR) radiation materials with desired broadband emissivity, excellent thermal stability, and scalable fabrication processes is highly desirable for energy‐saving applications heat dissipation. However, it remains a grand challenge to concurrently meet these requirements in existing IR materials. Herein, high‐entropy (HE) approach employed advance the performance of spinel oxide. This strategy efficiently narrows bandgap due enhanced electron transitions introduction oxygen vacancies (O v ), variable‐valence behavior, orbital hybridization. In addition, lattice distortion effect lowers symmetry vibration. Therefore, resulting HE oxide exhibits near‐blackbody performance, its emissivity approximately three times higher than that binary Moreover, entropy‐dominating phase stabilization contributes impressive stability (stable at 1300 °C 100 h). makes suitable high‐temperature applications, such as energy conservation industrial furnaces. More importantly, can be readily spray‐coated on various substrates. And coating stainless steel reaches an outstanding 0.943 0.78−16 µm wavelength range. All merits render competitive development high‐emissivity thermally stable

Language: Английский

Citations

31
Bioorthogonally Assisted Phototherapy: Recent Advances and Prospects DOI Creative Commons
Eszter Kozma, Márton Bojtár, Péter Kele

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)

Published: May 11, 2023

Photoresponsive materials offer excellent spatiotemporal control over biological processes and the emerging phototherapeutic methods are expected to have significant effects on targeted cancer therapies. Recent examples show that combination of photoactivatable approaches with bioorthogonal chemistry enhances precision phototherapies profound implications foreseen particularly in treatment disperse/diffuse tumors. The extra level on-target selectivity improved spatial/temporal considerably intensified related bioorthogonally assisted phototherapy research. anticipated growth further developments field justifies timeliness a brief summary state art.

Language: Английский

Citations

26
Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity DOI Creative Commons
Masaaki Akai, Kazuhiro Noma, Takuya Kato

et al.

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 130(10), P. 1647 - 1658

Published: March 30, 2024

Abstract Background Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role immunosuppression. However, targeted depletion of CAFs is difficult due to their diverse cells origin and resulting lack specific surface markers. Near-infrared photoimmunotherapy (NIR-PIT) novel cancer treatment that leads rapid cell membrane damage. Methods In this study, we used anti-mouse fibroblast activation protein (FAP) antibody target FAP + (FAP-targeted NIR-PIT) investigated whether therapy could suppress progression improve immunity. Results FAP-targeted NIR-PIT induced death without damaging adjacent normal cells. Furthermore, treated mice showed significant regression CAF-rich model accompanied by an increase CD8 infiltrating lymphocytes (TILs). Moreover, tumors increased levels IFN-γ, TNF-α, IL-2 TILs compared with non-treated tumors, suggesting enhanced antitumor Conclusions Cancers FAP-positive TME grow rapidly not only suppresses growth but improves Thus, potential therapeutic strategy for selectively targeting CAF tumors.

Language: Английский

Citations

12
Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy DOI Creative Commons
Hiroaki Wakiyama, Takuya Kato, Aki Furusawa

et al.

Cancer Immunology Research, Journal Year: 2022, Volume and Issue: 10(11), P. 1386 - 1397

Published: Sept. 28, 2022

Programmed cell death 1 (PD-1) blockade therapy can result in dramatic responses some patients with cancer. However, about 15% of receiving PD-1 experience rapid tumor progression, a phenomenon termed "hyperprogressive disease" (HPD). The mechanism(s) underlying HPD has been difficult to uncover because is challenging reproduce animal models. Near-infrared photoimmunotherapy (NIR-PIT) method by which specific cells the microenvironment (TME) be selectively depleted without disturbing other TME. In this study, we partially CD8+ T NIR-PIT targeting CD8β antigen thereby temporarily changing balance T-cell subsets two different syngeneic these models led progression compared controls. CD3ε+CD8α+/CD3ε+CD4+FoxP3+ (Teff/Treg) ratios and groups were lower than Moreover, bilateral model, low-dose CD8β-targeted anti-PD-1 showed only exposed NIR light. experiment reduced local resulting regulatory (Treg)-dominant conclusion, reports an model simulate Treg-dominant TME, data generated using suggest that after attributed, at least part, imbalances between effector Tregs

Language: Английский

Citations

35
Supramolecular cancer photoimmunotherapy based on precise peptide self-assembly design DOI
Yamei Liu, Lu Zhang, Rui Chang

et al.

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(14), P. 2247 - 2258

Published: Jan. 1, 2022

Combinational photoimmunotherapy (PIT) is considered to be an ideal strategy for the treatment of malignant cancer, because it can ablate primary tumor and induce host immune response control growth distal metastasis.

Language: Английский

Citations

34
Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy DOI
Jianwei Zhu, Yuning Zhang, Zheng Li

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(8), P. 3014 - 3023

Published: Jan. 1, 2023

Phototherapy-induced hypoxia in the tumor microenvironment (TME) is responsible for diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding to TME-responsive drug delivery will, some extent, improve efficacy and reduce side effects. Semiconducting polymers with high photothermal conversion efficiency photostability have tremendous potential as phototheranostics. In this paper, hypoxia-activatable tirapazamine (TPZ) was conjugated onto poly(ethylene glycol) form a pH-sensitive poly-prodrug, PEG-TPZ, that can be triggered by low acidity TME cleave acylamide bond controllable release. PEG-TPZ then used encapsulate semiconducting polymer (TDPP) NIR-II-fluorescence-imaging-guided synergistic therapy. The reactive oxygen species (ROS) generation ultrahigh (∼58.6%) TDPP@PEG-TPZ NPs leads destruction blood vessels, thus further activating hypoxia-induced chemotherapy TPZ. As result, effective regression achieved after laser irradiation.

Language: Английский

Citations

20
DNA and Nanomaterials: A Functional Combination for DNA Sensing DOI
Mohzibudin Z. Quazi,

Jang Hyeon Choi,

Min‐Chul Kim

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(2), P. 778 - 786

Published: Jan. 25, 2024

Recent decades have experienced tough situations due to the lack of reliable diagnostic facilities. The most recent cases occurred during pandemic, where researchers observed facilities with precision. Microorganisms and viral disease's ability escape diagnosis has been a global challenge. DNA always unique moiety strong precise base-paired structure. in human foreign particles makes identification possible through base pairing. Since then, focused heavily on designing assays targeting particular. Moreover, nanotechnology contributed vastly composite nanomaterials by combining DNA/nucleic acids functional inorganic nanoparticles exploiting their physicochemical properties. These often exhibit or enhanced properties synergistic activity many components. capabilities additional shown combination robust advanced tailoring biosensors. Preceding findings state that conventional strategies exhibited certain limitations such as low range target detection, less biodegradability, subordinate half-life, high susceptibility microenvironments; however, DNA–nanomaterial-based biosensor overcome these meaningfully. Additionally, nucleic studied extensively signal conduction abilities. Here, we review studies biosensors, mechanism action, improved/updated vivo situ. Furthermore, this highlights methodologies utilization exploit interfacial sensing. Lastly, concludes limitations/challenges future directions.

Language: Английский

Citations

8