Journal of Genetic Engineering and Biotechnology, Journal Year: 2025, Volume and Issue: 23(2), P. 100501 - 100501
Published: May 3, 2025
Language: Английский
Pharmacological Research, Journal Year: 2022, Volume and Issue: 184, P. 106418 - 106418
Published: Aug. 28, 2022
Language: Английский
Citations
114
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: July 6, 2022
Abstract Background Bacterial infection in wounds has become a major threat to human life and health. With the growth use of synthetic antibiotics elevated evolution drug resistant bacteria body cells requires development novel wound curing strategies. Herein, pH-responsive hydrogel (RPC/PB) was fabricated using poly(vinyl alcohol)-borax (PB) natural antibiotic resveratrol grafted cellulose nanofibrils (RPC) for bacterial-infected management. Results In this matrix, RPC conjugate interpenetrated PB network form semi-interpenetrating that exhibited robust mechanical properties (fracture strength 149.6 kPa), high self-healing efficiency (> 90%), excellent adhesion performance (tissue shear stress 54.2 kPa). Interestingly, induced RPC/PB showed release behavior, cumulative amount pH 5.4 2.33 times than 7.4, which adapted well acidic microenvironment. Additionally, biocompatibility antioxidant effect. Moreover, vitro vivo results revealed such had antibacterial, skin tissue regeneration closure capabilities. Conclusion Therefore, generated could be an dressing bacteria-infected healing.
Language: Английский
Citations
87
Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121616 - 121616
Published: June 2, 2022
Language: Английский
Citations
81
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113956 - 113956
Published: Nov. 2, 2022
Language: Английский
Citations
75
Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2771 - 2771
Published: Sept. 16, 2023
In this review, we have focused mainly on the study of their antioxidant and pro-oxidant capacity, analysis oxidation catechol group to o-quinone. The redox balance established between different oxidase reductase enzymes generates reducing species, H+ e−, allows polyphenolic groups quinones be reversible. This continuous these nucleophilic electrophilic substances activation NRF2/ARE axis, which regulates cellular responses against oxidative stress, as well cell proliferation. Understanding ambivalent character polyphenols, can act simultaneously antioxidants pro-oxidants, will allow design specific therapies that serve science medicine in tasks.
Language: Английский
Citations
51
Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5452 - 5452
Published: Aug. 25, 2022
Cancer is still one of the most widespread diseases globally, it considered a vital health challenge worldwide and main barriers to long life expectancy. Due potential toxicity lack selectivity conventional chemotherapeutic agents, discovering alternative treatments top priority. Plant-derived natural products have high in cancer treatment due their multiple mechanisms action, diversity structure, availability nature, relatively low toxicity. In this review, anticancer common phytochemicals were analyzed. Furthermore, detailed discussion effect combinations consisting product or with drugs was provided. This review should provide strong platform for researchers clinicians improve basic clinical research development medicines.
Language: Английский
Citations
52
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: July 20, 2022
Currently, systemic therapies for patients with advanced-stage hepatocellular carcinoma (HCC) rely mainly on drugs. However, traditional drugs have a high rate of serious adverse events, and the curative effects some potential anticancer drugs, such as curcumin (CUR) resveratrol (RSV), are less apparent due to their poor bioavailability. Therefore, it is urgent develop highly effective therapy improve patient prognosis. Herein, an injectable HCC-targeted nanoparticle (NP) was designed deliver CUR RSV hepatoma cells.The molecular self-assembled NPs showed higher tumour retention through enhanced permeability (EPR) effect surface modification HCC-specific peptide moiety SP94 effectively treat HCC. These led significant reduction in drug dosage, delayed release improved bioavailability encapsulated The concentrations vicinity increased, good therapeutic observed without obvious side effects.These SP94-mediated allowed large amounts antitumor accumulate tumours, providing novel strategy innovative HCC therapy. This nanoplatform also offers idea exploring other chemotherapeutics.
Language: Английский
Citations
50
Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1212 - 1212
Published: June 3, 2023
Reactive oxygen species (ROS) are important second messengers in many metabolic processes and signaling pathways. Disruption of the balance between ROS generation antioxidant defenses results overproduction subsequent oxidative damage to biomolecules cellular components that disturb function. Oxidative stress contributes initiation progression liver pathologies such as ischemia-reperfusion injury (LIRI), non-alcoholic fatty disease (NAFLD), hepatocellular carcinoma (HCC). Therefore, controlling production is an attractive therapeutic strategy relation their treatment. In recent years, increasing evidence has supported effects polyphenols on via regulation levels. current review, we summarize polyphenols, quercetin, resveratrol, curcumin, during conditions induce injury, LIRI, NAFLD, HCC.
Language: Английский
Citations
38
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 302, P. 123029 - 123029
Published: June 20, 2023
Language: Английский
Citations
30
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117404 - 117404
Published: Sept. 21, 2024
Language: Английский
Citations
15