Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109318 - 109318
Published: May 22, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: May 5, 2023
Liver cancer is now one of the main causes leading to death worldwide. To achieve reliable therapeutic effects, it crucial develop efficient approaches test novel anticancer drugs. Considering significant contribution tumor microenvironment cell’s response medications, in vitro 3D bioinspiration cell niches can be regarded as an advanced strategy improve accuracy and reliability drug-based treatment. In this regard, decellularized plant tissues perform suitable scaffolds for mammalian culture create a near-to-real condition drug efficacy. Here, we developed natural scaffold made from tomato hairy leaves (hereafter called DTL) mimic human hepatocellular carcinoma (HCC) pharmaceutical purposes. The surface hydrophilicity, mechanical properties, topography measurement molecular analyses revealed that DTL ideal candidate liver modeling. cells exhibited higher growth proliferation rate within scaffold, verified by quantifying expression related genes, DAPI staining, SEM imaging cells. Moreover, prilocaine, drug, showed effectiveness against cultured on compared 2D platform. Taken together, new cellulosic confidently proposed chemotherapeutic testing drugs carcinoma.
Language: Английский
Citations
8
Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(14), P. 15261 - 15276
Published: May 29, 2023
Hepatocellular carcinoma (HCC) is a common malignant tumor with insidious early symptoms, easy metastasis, postoperative recurrence, poor drug efficacy, and high resistance rate when surgery missed, leading to low 5-year survival rate. Research on the pathogenesis drugs particularly important for clinical treatment. Animal models are crucial basic research, which conducive studying screening more conveniently effectively. An appropriate animal model can better reflect disease occurrence development, process of anti-tumor immune response in human body. This review summarizes classification, characteristics, advances experimental HCC provide reference researchers selection.
Language: Английский
Citations
8
Gastro Hep Advances, Journal Year: 2023, Volume and Issue: 2(7), P. 948 - 963
Published: Jan. 1, 2023
Hepatocellular carcinoma (HCC) represents a high-fatality cancer with 5-year survival of 22%. The Wnt/β-catenin signaling pathway presents as one the most upregulated pathways in HCC. However, it has so far not been targetable clinical setting. Therefore, studying new targets this cascade from therapeutic aspect could enable reversal, delay, or prevention hepatocarcinogenesis. Although enormous advancement achieved HCC research and its management, since often occurs context other liver diseases such cirrhosis leading to dysfunction and/or impaired drug metabolism, current therapies face challenge safely effectively delivering drugs tumor site. In review, we discuss how targeted nano delivery system help minimize off-target toxicities conventional well enhance treatment efficacy. We also put forward challenges nanomedicine along some potential that be used for therapy. Overall, review will provide an insight advances, limitations change landscape undruggable pathway.
Language: Английский
Citations
8
Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1726 - 1726
Published: Oct. 18, 2024
Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies. They characterized by a peculiar tumor microenvironment and dense vascularization. The importance of signaling between immune cells, endothelial cells leads to the difficult recapitulation reliable in vitro HCC model using conventional two-dimensional cell cultures. advent three-dimensional organoid technology has revolutionized our understanding pathogenesis progression several malignancies faithfully replicating original cancer genomic, epigenomic, microenvironmental landscape. Organoids more closely mimic vivo environment interactions, factors such as spatial organization surface receptors gene expression, will probably become an important tool choice therapies evaluation response treatments. This review aimed describe ongoing potential applications organoids for study development, its interaction with host's immunity, analysis drug sensitivity tests, current limits this field.
Language: Английский
Citations
3
Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109318 - 109318
Published: May 22, 2024
Language: Английский
Citations
2